A5061800319- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Antibiotic Resistance in Bacteria
- Alzheimer's disease research and treatments
- Muscle and Compartmental Disorders
- Kawasaki Disease and Coronary Complications
- Erythrocyte Function and Pathophysiology
- Multiple Sclerosis Research Studies
- Genetic and Kidney Cyst Diseases
- Acute Kidney Injury Research
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Microscopic Colitis
- HIV Research and Treatment
- COVID-19 Impact on Reproduction
- Vascular Tumors and Angiosarcomas
- Poisoning and overdose treatments
- Liver physiology and pathology
- Dementia and Cognitive Impairment Research
Hacettepe University
2020-2024
Lindsay Unified School District
2023
Manhattan Institute for Policy Research
2023
New York Proton Center
2023
Communities In Schools of Orange County
2023
Oregon Medical Research Center
2023
Emory University
2016-2021
Children's Healthcare of Atlanta
2020
Altera (United States)
2020
Ankara University
2014
A wide spectrum of clinical manifestations has become a hallmark the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although immunological underpinnings diverse disease outcomes remain to be defined. We performed detailed characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation shared...
Abstract There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed disease who had encephalopathy and encephalitis develop. Neuroimaging showed nonenhancing unilateral, bilateral, midline changes not readily attributable to vascular causes. All increased cerebrospinal fluid (CSF) levels anti-S1 IgM. One patient died also anti-envelope protein CSF analysis markedly...
Inflammation is a common process involved in aging, multiple sclerosis (MS), and age-related neurodegenerative disorders such as Alzheimer's disease (AD) Parkinson's (PD), but there limited evidence for the effects of aging on inflammation central nervous system. We collected cerebrospinal fluid (CSF) from 105 healthy control subjects representing wide age range (23-86), analyzed levels cytokines associated innate immunity (TNF-alpha) different T-helper subtypes: interferon –gamma induced...
Abstract/Introduction A wide clinical spectrum has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic, although its immunologic underpinnings remain to be defined. We have performed deep characterization B cell responses through high-dimensional flow cytometry reveal substantial heterogeneity in both effector and immature populations. More notably, critically ill patients displayed hallmarks extrafollicular activation as previously described autoimmune settings. Extrafollicular...
Abstract Among patients with coronavirus disease (COVID-19), IgM levels increased early after symptom onset for those mild and severe disease, but IgG only in disease. A similar pattern was observed a separate serosurveillance cohort. Mild COVID-19 should be investigated separately from COVID-19.
Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently closed circular DNA (cccDNA)—the viral minichromosome—in nucleus hepatocytes. Current nucleoside analogs and interferon therapies rarely clear cccDNA, requiring lifelong treatment.
Abstract Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 related to microglial T-cell functions, show them reproducibly form functionally-related groups within across diagnostic categories in 382 participants from Disease Neuro-imaging Initiative as well two independent cohorts. We further higher levels soluble...
Heteroresistance is a form of antibiotic resistance in which phenotypically unstable subpopulation resistant cells exists within majority population susceptible cells. The impact the extracellular environment on mechanisms heteroresistance unclear. Studying fosfomycin an Enterobacter cloacae complex isolate, we observed that glucose availability greatly increased frequency subpopulation. Glucose downregulated glycerol and importer GlpT, whose expression was heterogenous at single cell level....
HIV-associated neurocognitive disorder (HAND) is a common condition in both developed and developing nations, but its cause largely unknown. Previous research has inconsistently linked Alzheimer's disease (AD), viral burden, inflammation to the onset of HAND HIV-infected individuals. Here we simultaneously measured cerebrospinal fluid (CSF) levels established amyloid tau biomarkers for AD, copy numbers, six key cytokines 41 individuals off combination anti-retroviral therapy (14 with HAND)...
Background: Accurate serological assays can improve the early diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but few studies have compared performance characteristics between in symptomatic and recovered patients. Methods: We recruited 32 patients who had 2019 disease (COVID-19; 18 hospitalized actively symptomatic, 14 mild cases), measured levels IgM (against full-length S1 or highly homologous SARS-CoV E protein) IgG receptor binding domain [RBD])....
Abstract Background & Aims Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms ( SNP s) the IL ‐28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HB sAg persistence. Further, effect on development eAg‐negative CHB vs. inactive carrier state assessed in genotype D HBV cohort. A cohort chronic HDV patients also used see if they behave differently compared patients. Methods This conducted three main...
ABSTRACT Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause chain termination. Here, we expand our studies on β- d -2′- -methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhibitor of HCV. DAPN-PD1 is metabolized intracellularly into two distinct bioactive nucleoside triphosphate (TP) analogs. The first metabolite, 2′- -methyl-GTP,...
Congenital hepatic fibrosis (CHF) is a developmental liver disease that caused by mutations in genes encode ciliary proteins and characterized bile duct dysplasia portal fibrosis. Recent work has demonstrated ANKS6 can cause CHF due to its role development. Here, we report novel mutation, which was identified an infant presenting with neonatal jaundice underlying biliary abnormalities Molecular analysis revealed pathology associated the infiltration of inflammatory macrophages periportal...
Nucleoside analog inhibitors (NAIs) are an important class of antiviral agents. Although highly effective, some NAIs with activity against hepatitis C virus (HCV) can cause toxicity, presumably due to off-target inhibition host mitochondrial RNA polymerase (POLRMT). The in vitro nucleotide substrate specificity POLRMT was studied order explore structure-activity relationships that facilitate the identification nontoxic NAIs. These findings have implications for development all anti-RNA
Recessive mutations in the genes encoding four subunits of tRNA splicing endonuclease complex (TSEN54, TSEN34, TSEN15, and TSEN2) cause various forms pontocerebellar hypoplasia, a disorder characterized by hypoplasia cerebellum pons, microcephaly, dysmorphisms, other variable clinical features. Here, we report an intronic recessive founder variant gene TSEN2 that results abnormal mRNA this gene, six individuals from consanguineous families affected with multiple craniofacial malformations,...
Abstract Background Following the pandemic of COVID-19, main focus has been on COVID-19 vaccines and herd immunity. Although safety shown in clinical trials, children with chronic diseases were not included. We investigated side effect profile adolescents kidney disease. Methods A questionnaire including demographic information, history vaccination status, vaccine-related effects was administered to patients disease (CKD) stage 2–5, glomerular treated immunosuppression, transplant...
Spindle cell hemangioma (SCH) is a benign unusual vascular neoplasm. It does not have gender predilection and can occur at all ages. The disease affects dermis subcutis of distal extremities predominantly; head neck involvement very rare, paranasal sinus has been reported before. Herein we present 4-month-old infant with nasal obstruction since two weeks age due to mass in ethmoid obliterating the passage. After histopathological diagnosis SCH, tumor was partially resected. In sixth month...