A5035498164- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Spinal Hematomas and Complications
- Immune Cell Function and Interaction
- PARP inhibition in cancer therapy
- Musculoskeletal pain and rehabilitation
- Plant Molecular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Fungal Biology and Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Marine Sponges and Natural Products
- Protein Tyrosine Phosphatases
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
Zhejiang Cancer Hospital
2022-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2022
Zhejiang Academy of Social Sciences
2022
Zhongda Hospital Southeast University
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2022
State Key Laboratory of Pharmaceutical Biotechnology
2016-2021
Nanjing University
2016-2021
Nanjing Drum Tower Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Abstract microRNAs (miRNAs) have emerged as major regulators of the initiation and progression human cancers, including breast cancer. The aim this study is to determine expression pattern miR-96 in cancer investigate its biological role during tumorigenesis. We showed that was significantly upregulated then investigated function found promoted cell proliferation, migration invasion vitro enhanced tumor growth vivo . Furthermore, we explored molecular mechanisms by which contributes...
Abstract RNAi therapy has undergone two stages of development, direct injection synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not solved the problem efficient in vivo siRNA delivery. Here, we present a proof-of-principle strategy that reprogrammes host liver genetic circuits to synthesis self-assembly into secretory exosomes facilitate through circulating exosomes. By combination different circuit modules, assembled are systematically distributed...
Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as tumor suppressor in many cancer types, including colorectal (CRC). During CRC carcinogenesis, PDCD4 levels remarkably decrease, but the underlying molecular mechanism for decreased expression not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs potentially target PDCD4. We demonstrated miR-181b direct regulator of further showed activation IL6/STAT3 signaling pathway increased and...
Protein tyrosine phosphatase receptor type G (PTPRG) is an important tumor suppressor gene in multiple human cancers. In this study, we found that PTPRG protein levels were downregulated breast cancer tissues while the mRNA varied irregularly, implying a post-transcriptional mechanism was involved. Because microRNAs are powerful regulators of expression, used bioinformatics analysis to search for potentially targets setting cancer. We identified two specific binding sites miR-19b...
Abstract Nonreceptor tyrosine kinase c‐Src, also known as Src, is a potent oncogene involved in series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern function esophageal cancer poorly addressed. In this study, abnormal overexpression Src protein was observed tissues, which fuelled the speculation that microRNA‐mediated posttranscriptional regulatory mechanism might be involved. Bioinformatic analyses were applied to identify...
Background and Objective: Gastric Carcinoma (GC) is categorized among malignant tumours with an extremely increased fatality rate, incidence constantly rising in recent years.Accumulating studies have pointed out that lncRNA may be the breakthrough fight against tumour diseases.The purpose of this investigation was to explore mechanism PVT1 on gastric carcinoma cells.Materials Methods: SGC7901 MGC803 GC cell multiplication, invasion apoptosis were studied under altering expressions...