A5044875054- Mercury impact and mitigation studies
- Antioxidant Activity and Oxidative Stress
- Heavy Metal Exposure and Toxicity
- Aquaculture disease management and microbiota
- Neuropeptides and Animal Physiology
- CRISPR and Genetic Engineering
- Carcinogens and Genotoxicity Assessment
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Mosquito-borne diseases and control
- Animal Genetics and Reproduction
- Phytochemistry Medicinal Plant Applications
- Aquaculture Nutrition and Growth
- Pharmacological Effects and Toxicity Studies
- Reproductive biology and impacts on aquatic species
- Trace Elements in Health
- Anesthesia and Neurotoxicity Research
- Environmental Toxicology and Ecotoxicology
- Trypanosoma species research and implications
Universidade Federal do Pará
2014-2024
Human exposure to relatively low levels of methylmercury is worrying, especially in terms its genotoxicity. It currently unknown as whether mercury (below established limits) safe. Genotoxicity was already shown lymphocytes, but studies with cells the CNS (as main target organ) are scarce. Moreover, disturbances cell cycle and cellular proliferation have previously been observed neuronal cells, no data presently available for glial cells. Interestingly, origin accumulate higher...
Chronic alcohol intoxication (CAI) increases both morbidity and mortality of stroke patients. Despite the high prevalence CAI ischemic stroke, studies addressing their comorbidity and/or protective alternatives remain scarce. Thus, influence on outcome minocycline treatment (recognized for its neuroprotective effect) was investigated. Female Wistar rats (35 days old) were treated with water or ethanol (6.5 g/kg/day, 22.5% w/v) 55 days. Then, focal ischemia induced by endothelin‐1 in motor...
Morphine is a potent analgesic opioid used extensively for pain treatment. During the last decade, global consumption grew more than 4-fold. However, molecular mechanisms elicited by morphine are not totally understood. Thus, growing literature indicates that there additional actions to effect. Previous studies about and oxidative stress controversial concentrations outside range of clinical practice. Therefore, in this study, we hypothesized therapeutic concentration (1 μM) would show...
Mercury is an extremely dangerous environmental contaminant responsible for episodes of human intoxication throughout the world. Methylmercury, most toxic compound this metal, mainly targets central nervous system, accumulating preferentially in cells glial origin and causing oxidative stress. Despite studies demonstrating current exposure populations, consequences mercury concomitant use drugs targeting system (especially used long-term treatments, such as analgesics) are completely...
Abstract Intending to compare in vitro cell growth different conditions, we established cultures using fin biopsies of two freshwater fishes, Astyanax bimaculatus and Geophagus proximus . Three culture media (Leibovitz–L‐15, Dulbecco's Modified Eagle Medium [DMEM], 199) were employed, with or without the addition AmnioMax, maintaining a standard temperature 29°C. Based on results obtained, standardized protocol which medium 199 was less efficient for both species. Notably, G. cells exhibited...
Mercury is widely used in industrial and extractive processes, the improper disposal of waste or products containing this metal produces a significant impact on ecosystems, causing adverse effects living organisms, including humans. Exposure to methylmercury, highly toxic organic compound, causes important neurological developmental impairments. Recently, genotoxicity mercurial compounds has gained prominence as one possible mechanisms associated with mercury, mostly by disturbing mitotic...
Abstract The establishment of cell lines from fish species is becoming important because the increase in interest these cells for viral analysis, environmental monitoring and cytogenetic studies. However, there some discussion about best conditions maintaining cells. We describe here a protocol primary which we have found to be reliable. Fin biopsies two species, Geophagus proximus Astyanax bimaculatus , were isolated cultured. used three culture media (Leibovitz-L15, Dulbecco s Modified...
Introdução: Embora identificada a mais de 100 anos, Doença Chagas continua sem controle no Brasil, tanto em função do número instável casos quanto pela carência políticas públicas enfrentamento efetivas. Em contexto recente o monitoramento dessa e outras doenças tropicais negligenciadas pode ter perdido qualidade da chegada novas agudas país decorrente sobrecarga trabalho nos serviços cuidado atenção saúde. Objetivo: avaliar perfil epidemiológico DCA através comparação das séries históricas...