A5103093674- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Infectious Diseases and Tuberculosis
- Hepatitis B Virus Studies
- Radiology practices and education
- Antibiotic Resistance in Bacteria
- Parasitic infections in humans and animals
- Computational Drug Discovery Methods
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Medicine and Dermatology Studies History
- Phenothiazines and Benzothiazines Synthesis and Activities
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Innovations in Medical Education
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- Hematological disorders and diagnostics
- Spine and Intervertebral Disc Pathology
- Anesthesia and Pain Management
- Parasite Biology and Host Interactions
- Cerebrovascular and Carotid Artery Diseases
- Complement system in diseases
- Orthopedic Infections and Treatments
Indiana University – Purdue University Indianapolis
2013-2024
Indiana University School of Medicine
2013-2024
Institute of Medical Sciences
2005-2023
Swami Rama Himalayan University
2005-2023
Rajasthan University of Health Sciences
2023
Riley Hospital for Children
2022
Govind Ballabh Pant Hospital
2017-2021
Dr. Ram Manohar Lohia Institute of Medical Sciences
2021
Sarojini Naidu Medical College
2020
Achillion Pharmaceuticals (United States)
2006-2017
Diffuse axonal injury (DAI) that follows traumatic brain (TBI) is thought to be a major contributor neurocognitive dysfunction sometimes TBI. Conventional magnetic resonance imaging (MRI), diffusion tensor (DTI) and neuropsychological tests (NPT) were performed on 38 TBI patients [hemorrhagic DAI (H-DAI, n = 8), non-hemorrhagic (Nh-DAI, 7), with no apparent conventional MRI (NA-DAI, 23)] Glasgow Coma Scale score ranging between 9 13. The fractional anisotropy (FA) mean diffusivity (MD)...
Background and Objectives Diagnosis of tumefactive demyelinating lesions (TDLs) is challenging to both clinicians radiologists. Our objective in this study was analyze characterize these clinically, biochemically, electrophysiologically, on imaging. Methods A retrospective analysis with prospective follow-up 18 cases TDLs performed. Imaging included T2-, T1-weighted, fluid-attenuated inversion recovery (FLAIR), post-contrast diffusion weighted imaging (DWI), proton magnetic resonance...
Stroke is a devastating complication of tuberculous meningitis and an important determinant its outcome.To prospectively evaluate the predictive factors for stroke in patients with to assess impact on overall prognosis outcome.We evaluated followed 100 6 months. Magnetic resonance imaging was performed at inclusion after We predictors also assessed effect outcome. Outcome defined help modified Rankin scale.Of patients, lost follow-up. Thirty had stroke, 27 them inclusion. Three developed...
To detect lesion-related focal Wallerian degeneration (WD) changes in different segments of the corpus callosum (CC) patients with large middle cerebral arterial (MCA) territory stroke using diffusion tensor imaging (DTI).Eight underwent DTI scans at three time points: six to eight weeks, 10-12 and beyond months onset. Eight healthy age-matched controls were also scanned same protocol points. Region-of-interest (ROI) analysis was performed on seven CC determine fractional anisotropy (FA),...
The design and synthesis of a series seven tricyclic 6-methylidene penems as novel class A C serine β-lactamase inhibitors is described. These compounds proved to be very potent the TEM-1 AmpC β-lactamases less so against B metallo-β-lactamase CcrA. In combination with piperacillin, their in vitro activities enhanced susceptibility all resistant strains from various bacteria. Crystallographic structures serine-bound reaction intermediate 17 SHV-1 GC1 enzymes have been established resolutions...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison the Hansch and CoMFA methodsAtul Agarwal, Philip P. Pearson, Ethan Will Taylor, Hong B. Li, Torsten Dahlgren, Margareta Herslof, Youhua Yang, Georgina Lambert, David L. Nelson, Cite this: J. Med. Chem. 1993, 36, 25, 4006–4014Publication Date (Print):December 1, 1993Publication History Published...
Summary: Purpose: The main objective of this study was to use diffusion tensor imaging (DTI) search and quantify the extent abnormality beyond obvious lesions seen on T 2 fluid‐attenuation inversion recovery (FLAIR) magnetic resonance images in patients with chronic traumatic brain injury (TBI) without epilepsy. Methods: DTI performed 23 TBI (with late posttraumatic epilepsy, n = 14; 9) 11 age‐matched controls. ratios fractional anisotropy (FA) mean diffusivity (MD) between regions interest...
Abstract Treatment with Centchroman (3,4‐trans‐2,2‐dimethyl‐3‐phenyl‐4‐p‐(βpyrrolidinoethoxy) phenyl‐7‐methoxy chroman) has been evaluated in 4 male and 75 female patients advanced breast cancer. The overall response rate, including both cases, was 40.5%. Among the patients, rate 38.7%. median duration of 6 months. One showed a complete 2 partial responses. responses were more marked for bone, pulmonary, soft tissue, skin lymph‐node metastases than liver metastases.
A series of potent anthranilic acid-based inhibitors the hepatitis C NS5B polymerase has been identified. The bind to a site on between thumb and palm regions adjacent active as determined by X-ray crystallography enzyme-inhibitor complex. Guided both molecular modeling traditional SAR, enzyme activity initial hit was improved approximately 100-fold, yielding selective with IC50 values low 10 nM. These compounds were also HCV replicon in cultured HUH7 cells.
Summary: Purpose: To evaluate the role of a short course oral corticosteroids in Indian patients with solitary cysticercus granuloma seizures. Methods: In this open‐label, randomized, prospective follow‐up study, 97 new‐onset seizures and single enhancing computed tomography (CT)‐detected lesion cysticercosis were randomly divided two groups to receive either antiepileptic monotherapy alone (n = 48) or prednisolone 49). The latter group received prednisolone, 1 mg/kg/day for 10 days,...
The hepatitis C virus (HCV) encodes an RNA-dependent RNA polymerase (NS5B), which is indispensable for the viral genome replication. Although structural comparison among HCV NS5B, poliovirus 3D-pol, and human immunodeficiency virus-reverse transcriptase reveals canonical palm, fingers, thumb domains, crystal structure of NS5B highlights presence a unique A1-loop, extends from fingers to domain (amino acids 12–46), providing many contact points proposed "closed" conformation enzyme. also...
We undertook this study to determine the causes of peritoneal calcification seen on CT and investigate which features distinguish benign from malignant calcification.Seventeen patients with were identified through retrospective review reports 74765 abdominopelvic examinations performed during a 7-year period. determined cause by examining medical histopathologic records. Calcification morphology was classified as nodular or sheetlike basis consensus interpretation two independent...
A new pyranoindole class of small-molecule inhibitors was studied to understand viral resistance and elucidate the mechanism inhibition in hepatitis C virus (HCV) replication. HCV replicon variants less susceptible by pyranoindoles were selected Huh-7 hepatoma cells. Variant replicons contained clusters mutations NS5B polymerase gene corresponding drug-binding pocket on surface thumb domain identified X-ray crystallography. An additional cluster present part a unique beta-hairpin loop also...
Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions the lead molecule resulted in compounds that displayed good potency and selectivity. The crystal structure complex confirmed binding near active site region. optimization approach SAR are discussed detail.
We have discovered a novel class of compounds active against hepatitis C virus (HCV), using surrogate cellular system, HCV replicon cells. The leading compound in the series, ACH-806 (GS-9132), is potent and specific inhibitor HCV. selection resistance variants was performed to map mutations conferring determine cross-resistance profiles with other classes inhibitors. Several clones emerged after addition cells at frequencies durations similar that observed NS3 protease inhibitors NS5B...
Bacteriorhodopsin (BR) is a membrane protein of known structure, widely used for the homology modeling G-protein-coupled receptors (GPCR). The observation apparently transposed sequence similarities between some helical domains BR and GPCR has led to suggestion that exon shuffling may have occurred in later evolution GPCR, which would necessitate different folding pattern seven transmembrane helices GPCR. An alternate hypothesis duplication an ancestral gene, such 5-7 originated as...
Abstract The affinity of a ligand for receptor is usually expressed in terms the dissociation constant ( K i ) drug‐receptor complex, conveniently measured by inhibition radioligand binding. However, can be an antagonist, partial agonist, or full property largely independent its affinity. This quantitated as intrinsic activity (1A), which range from 0 antagonist to 1 agonist. Although quantitative structure–activity relationship (QSAR) methods have been applied prediction with considerable...