A5074773973- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immune Response and Inflammation
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Hematopoietic Stem Cell Transplantation
- Diamond and Carbon-based Materials Research
- Angiogenesis and VEGF in Cancer
- Polymer Nanocomposite Synthesis and Irradiation
- Erythropoietin and Anemia Treatment
- Proteoglycans and glycosaminoglycans research
- Adipokines, Inflammation, and Metabolic Diseases
- Metal and Thin Film Mechanics
- Apelin-related biomedical research
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Adipose Tissue and Metabolism
Immanuel Kant Baltic Federal University
2016-2025
Science & Technology Park (Czechia)
2021-2023
Institute of High Current Electronics
2020-2022
Siberian Branch of the Russian Academy of Sciences
2021
Saint-Petersburg Research Institute of Phthisiopulmonology
2017
A number of preclinical and clinical studies have demonstrated the efficiency mesenchymal stromal cells to serve as an excellent base for a cell-mediated drug delivery system. Cell-based targeted has received much attention system facilitate uptake nd transfer active substances specific organs tissues with high efficiency. Human stem (MSCs) are attracting increased interest promising tool cell-based therapy due their proliferative capacity, multi-potency, anti-inflammatory immunomodulatory...
Cell therapy is among the main methodological approaches in regenerative medicine. Its effectiveness determined by use of cell cultures containing largest available number viable cells. An important role this process played growth factors that ensure proliferation and differentiation. Both recombinant proteins native from various biological fluids may be used as factors. Blood platelets, being anucleate cells, are a promising source Along with their blood clotting function, platelets contain...
Abstract: The maintenance of the functional potential mitochondria is directly related to epigenetic factors, microRNAs (miRs), and mitomicroRNAs (mitomiRs). An important role in development metabolic syndrome (MetS)/obesity attributed miRs, which have pro-inflammatory or anti-inflammatory can penetrate mitochondrial matrix. Deciphering mechanisms responsible for transport miRs into would, we believe, allow us use knowledge obtained build designs drugs/mitomiRs cells/mitochondria with low...
This work describes the wettability and biological performance of Zn- Cu-containing CaP-based coatings prepared by micro-arc oxidation on pure titanium (Ti) novel Ti-40Nb alloy. Good hydrophilic properties all were demonstrated low contact angles with liquids, not exceeding 45°. An increase in applied voltage led to an coating roughness porosity, thereby reducing 6° water 17° glycerol. The free surface energy 75 ± 3 mJ/m2 for determined. Polar component was calculated as main energy, caused...
New TiNb-based alloys, such as Ti–6Al–7Nb, are currently being studied around the world an alternative to other Ti e.g., instead of Ti–6Al–4V. We conducted a pilot study where thin (approximately 1.2 micron) CaP coatings containing low doses Zn2+ (0.4–0.8 wt.%) were prepared by radio frequency magnetron sputtering (RFMS) Zn-hydroxyapatite (HA) target on Ti–6Al–4V and Ti–6Al–7Nb substrates investigated their physicochemical properties, in vitro solubility, cytotoxicity, antibacterial...
Calcium phosphate (CaP) materials do not always induce ectopic vascularization and bone formation; the reasons remain unclear, there are active discussions of potential roles for post-implantation hematoma, circulating immune stem cells, pericytes, but studies on adipose-derived cells (AMSCs) in this context lacking. The rough (average surface roughness Ra = 2-5 µm) scaffold-like CaP coating deposited pure titanium plates by microarc oxidation method was used to investigate its subcutaneous...
СD3+ T lymphocytes were isolated by positive magnetic separation from the peripheral blood of healthy donors. In absence any additional activating stimuli, interleukin-7 (IL-7) was shown to augment levels cells expressing CD25 activation marker both in СD4-positive and CD4-negative effector memory (CD45RA-CD197-) cell subsets, as well terminally differentiated (CD45RA+CD197-) Т cells, without significantly affecting status naive (CD45RA+CD197+) central (CD45RA-CD197+) cells. addition, IL-7...
Abstract The article deals with the plasma‐assisted chemical vapor deposition of 0.3–1.4 μm thick a‐C:H:SiO x films in a mixture argon and polyphenylmethylsiloxane onto Ti–6Al–4V alloy substrate, which is often used as an implant material. film structure studied by Fourier‐transform infrared Raman spectroscopies. pull‐off adhesion test assesses adhesive strength films, ball‐on‐disk method employed to measure their wear rate friction coefficient. According these studies, are highly have low...