A5069155164- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Cytokine Signaling Pathways and Interactions
- Periodontal Regeneration and Treatments
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Graphene and Nanomaterials Applications
- Bone fractures and treatments
- Immune Cell Function and Interaction
- Spaceflight effects on biology
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Proteoglycans and glycosaminoglycans research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Orthopaedic implants and arthroplasty
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Graphene research and applications
- Regulation of Appetite and Obesity
Immanuel Kant Baltic Federal University
2018-2023
Science & Technology Park (Czechia)
2021
Interleukin (IL)-6 family cytokines act through a receptor complex with gp130 subunits. IL-6 is pleiotropic cytokine that regulates inflammation and liver regeneration. Mitochondria are the first to respond stress adapt their dynamics in conditions of damage. In this regard, study aimed investigate role (sIL-6Ra, gp130/sIL-6Rb, IL-11) regulation mitochondrial obese patients assess contribution these pathogenesis type 2 diabetes mellitus (T2DM). We studied 134 without T2DM 41 healthy donors....
Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify mechanisms interaction critical regulators carbohydrate metabolism using bioinformatics experimental methods assess their influence on development T2DM. We conducted an in silico search for relationship hormones adipokines performed functional annotation receptors ghrelin incretins. Hormones were assessed plasma obese patients with without T2DM as well after...
New TiNb-based alloys, such as Ti–6Al–7Nb, are currently being studied around the world an alternative to other Ti e.g., instead of Ti–6Al–4V. We conducted a pilot study where thin (approximately 1.2 micron) CaP coatings containing low doses Zn2+ (0.4–0.8 wt.%) were prepared by radio frequency magnetron sputtering (RFMS) Zn-hydroxyapatite (HA) target on Ti–6Al–4V and Ti–6Al–7Nb substrates investigated their physicochemical properties, in vitro solubility, cytotoxicity, antibacterial...
Calcium phosphate (CaP) materials do not always induce ectopic vascularization and bone formation; the reasons remain unclear, there are active discussions of potential roles for post-implantation hematoma, circulating immune stem cells, pericytes, but studies on adipose-derived cells (AMSCs) in this context lacking. The rough (average surface roughness Ra = 2-5 µm) scaffold-like CaP coating deposited pure titanium plates by microarc oxidation method was used to investigate its subcutaneous...
Calcium phosphate (CaP) materials are among the best bone graft substitutes, but their use in repair of damaged tumor patients is still unclear. The human Jurkat T lymphoblast leukemia-derived cell line (Jurkat cells) was exposed vitro to a titanium (Ti) substrate (10 × 10 1 mm3) with bilateral rough (average roughness index (Ra) = 2-5 μm) CaP coating applied via microarc oxidation (MAO) technique, and morphofunctional response cells studied. Scanning electron microscopy (SEM), X-ray...
The manufacture of biomaterial surfaces with desired physical and chemical properties that can directly induce osteogenic differentiation without the need for biochemical additives is an excellent strategy controlling behavior mesenchymal stem cells (MSCs) in vivo. We studied cellular molecular reactions MSCs to samples a double-sided calcium phosphate (CaP) coating average roughness index (Ra) 2.4-4.6 µm. study aimed evaluate effect three-dimensional matrix on relative mRNA expression...
Background: Molecular genetic mechanisms, signaling pathways, conditions, factors, and markers of the osteogenic differentiation mesenchymal stem cells (MSCs) are being actively studied among most areas in field cellular technology. This attention is largely due to mounting contradictions seemingly classical knowledge constant updating results analyzed areas. In this regard, we focus on main concepts some new factors mechanisms that have a noticeable regulatory effect potential postnatal...
Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control survival, proliferation, differentiation, effector function immune cells. All components TNF are associated with NF-kB functions not limited to cell death may promote survival in face adipose tissue inflammation obesity. Inflammation dysfunction mitochondria is a key insulin resistance The aim study was analyze relationship soluble forms blood plasma...
Obesity is the main cause of metabolic complications. Fatty liver infiltration a companion obesity. NAFLD associated with impaired energy metabolism an excess nutrients. Mitochondrial dynamics are important for regulation balance, which regulates mitochondrial function, apoptosis, and mitophagy. The aim this study was to investigate effect gp130 on components in cellular model steatohepatitis. Addition IL-6/gp130 contributed increase percentage live cells decrease dead apoptotic cells....
Secretion of 21 cytokines, chemokines and growth factors (LIF, SCF, SDF-1a, SCGF-b, M-CSF, MCP-3, MIF, MIG, TRAIL, GRO-a; IL-1a, IL-2ra, IL-3, IL-12(p40), IL-16, IL-18, HGF, TNF-b, b-NGF, IFN-a2, CTACK) has been studied in vitro the culture human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) conditions its osteogenic differentiation caused by 14-day contact with calcium phosphate (CP) surface different roughness. Bilateral X-ray amorphous CP coatings were prepared on...
Synthetic materials used in regenerative medicine, upon implantation, induce the development of an inflammatory reaction necessary for effective regeneration damaged bone tissue. Implant contact with tissues is accompanied by deposition blood proteins and interstitial fluid on its surface, contributing to activation complement system, components innate immunity, initiating coagulation hemostasis, leading formation a fibrin clot. An extracellular matrix based fibrin, collagen elastin forms...
Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control survival, proliferation, differentiation, effector function immune cells. All components TNF are associated with NF-kB functions not limited to cell death may promote survival in face adipose tissue inflammation obesity. Inflammation pro-inflammatory dysfunction mitochondria key factors insulin resistance The aim study was analyze relationship soluble forms...
Currently, there is an increasing demand for biocompatible materials that can be used bone reconstruction. However, still no consensus regarding adequate replacement material. The traditionally reconstructive surgeries, and methods of making bone-replacing implants from them have various disadvantages. They do not fully satisfy the biological biomechanical characteristics living tissues. This leads to a clinical situation called "implant failure” consists violation its integrity, loosening,...