A5049438608- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Traditional Chinese Medicine Analysis
- Protein Hydrolysis and Bioactive Peptides
- Aquaculture Nutrition and Growth
- Bioactive Compounds in Plants
- Electrochemical sensors and biosensors
- Pesticide Residue Analysis and Safety
- Natural Antidiabetic Agents Studies
- Diabetes Treatment and Management
- Phytochemistry and Biological Activities
- Insect Utilization and Effects
- HIV/AIDS drug development and treatment
- Pharmacology and Obesity Treatment
- Biochemical and Structural Characterization
- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Peptidase Inhibition and Analysis
- Ginseng Biological Effects and Applications
- Chromatography in Natural Products
Beijing University of Chinese Medicine
2015-2025
Heilongjiang University
2025
Anhui Medical University
2010
Neuroinflammation is a significant driving force in the pathogenesis and progression of central nervous system (CNS) disorders. Polymethoxylated flavones (PMFs), key lipid-soluble constituents Citri Reticulatae Pericarpium (CRP), exhibit excellent blood-brain barrier permeability anti-inflammatory properties, holding therapeutic potential for CNS However, specific bioactive components effects PMFs treating disorders are not well understood. This study employed comprehensive sequential...
Purpose: Inhibition of dipeptidyl peptidase-IV (DPP-IV) is an effective therapy for treating type II diabetes (T2D) that has been widely applied in clinical practice. We aimed to evaluate the DPP-IV inhibitory properties ginger protease hydrolysate (GPH) and propose a comprehensive approach screen inhibitors. Methods: evaluated vitro fish skin gelatin hydrolysates produced by five proteases, namely, neutral protease, alkaline bromelain, papain, toward DPP-IV. screened most potent peptide...
(1) Methods: An integrated strategy, including in vitro study (degree of hydrolysis (DH) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity) vivo (absorption after oral administration rats), was developed to evaluate the properties fish skin gelatin hydrolysates prepared using different proteases (pepsin, alkaline protease, bromelain, ginger protease). Meanwhile, order identify site peptides protease-degraded collagen hydrolysate (GDCH) were comprehensively characterized by...
Traditional Chinese medicine (TCM) possesses unique advantages in the management of blood glucose and lipids. However, there is still a significant gap exploration its pharmacologically active components. Integrated strategies encompassing deep-learning prediction models validation based on absorbable ingredients can greatly improve identification rate screening efficiency TCM. In this study, affinity 11,549 compounds from traditional system's pharmacology database (TCMSP) with dipeptidyl...
Chrysanthemum morifolium Ramat. is a kind of food and drug dual-use traditional Chinese medicine possessing multiple pharmacological biochemical benefits. In our study, rapid high-throughput method based on Surface plasmon resonance (SPR) biosensor technology was developed verified for screening potential xanthine oxidase (XOD) inhibitors exemplarily in the Coupled with ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS), 14 XOD-binders...
Background: Orlistat is commonly as a potent and long-lasting specific inhibitor of gastric pancreatic lipase. Seven potential process-related impurities degradation products were discovered in orlistat capsule out which two novel. However, no analytical methods reported the literature could separate all presented this work. Therefore, it necessary to develop simple, rapid reliable HPLC method detect pharmaceutical dosage forms identify novel impurities. Methods Results: The drug was...
Our aim is to build a physiologically based pharmacokinetic and JAK2 occupancy model (PBPK-JO) simultaneously predict (PK) pharmacodynamic (PD) changes of baricitinib (BAR) in healthy human when co-administration with kidney transporters OAT3 MATE2-K inhibitors, patients hepatic renal impairment. Probenecid vandetanib were selected as competitive respectively. Here, we have successfully simulated PK profiles by PBPK-JO model. Moreover, this modelling reproduced every observed data, mean...
Background Aging is marked by the gradual deterioration of cells, tissues, and organs a major risk factor for many chronic diseases. Considering complex mechanisms aging, traditional Chinese medicine (TCM) could offer distinct advantages. However, due to complexity variability metabolites in TCM, comprehensive screening associated with pharmacology remains significant issue. Methods A reliable integrated identification method based on UPLC-Q Exactive-Orbitrap HRMS was established identify...
So far, there has been no advanced method to assure the quality control for Astragalus. However, this paper summarizes a fingerprinting approach, which based on developed high performance liquid chromatography provide reference scientific evaluation of intrinsic To assess chemical content Astragalus in different years and producing areas, we determined 22 batches samples through cluster analysis similar calculations. According clustering analysis, group two-year-old into three categories,...