A5100395385- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Hair Growth and Disorders
- Cancer, Hypoxia, and Metabolism
- Silicone and Siloxane Chemistry
- Reconstructive Surgery and Microvascular Techniques
- Electrospun Nanofibers in Biomedical Applications
- Skin and Cellular Biology Research
- Reconstructive Facial Surgery Techniques
- Dental Implant Techniques and Outcomes
- Dermatologic Treatments and Research
- Mesenchymal stem cell research
- Dental materials and restorations
- Breast Implant and Reconstruction
- Facial Rejuvenation and Surgery Techniques
- PI3K/AKT/mTOR signaling in cancer
- Rock Mechanics and Modeling
- Bacteriophages and microbial interactions
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Polymer Nanocomposite Synthesis and Irradiation
- Graphene and Nanomaterials Applications
- Botulinum Toxin and Related Neurological Disorders
- 3D Printing in Biomedical Research
Hunan Normal University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jining First People's Hospital
2025
University of Southern California
2025
Xinqiao Hospital
2014-2024
Army Medical University
2014-2024
Daping Hospital
2023
Xi'an University of Science and Technology
2023
Novartis (United States)
2013-2022
Tianjin Medical University General Hospital
2021
Background: The timely management of large-scale wounds and the regeneration skin appendages constitute major clinical issues. production high-precision customizable artificial via 3D bioprinting offers a feasible means to surmount predicament, within which selection bioactive materials seed cells is critical. This study aimed at employing stem multicomponent hydrogels prefabricate through bioprinting, enables its appendages. Methods Results: We employed gelatin methacrylate (GelMA)...
The periodic growth of hair follicles is regulated by the balance activators and inhibitors. BMP signaling pathway plays an important role during follicle regeneration, but exact protein that controls this process has not been revealed. expression BMP6 was determined via in situ hybridization immunofluorescence. vivo effect overexpression studied using a previously established adenovirus injection model. regeneration assessed gross observation, H&E staining 5-bromo-2-deoxyuridine (BrdU)...
Depression is a common mental disorder that presents considerable challenge for public health. The natural product geniposide has neuroprotective effects on depression, but the underlying mechanism behind these had remained undefined. present study was designed to investigate role of microRNAs (miRs) in this mechanism. It studied mice with depression-like behavior established by exposure chronic unpredictable mild stress (CUMS) 2 months. CUMS were intragastrically fed at dose 10 ml/kg daily...
Mitochondrial membrane permeability has received considerable attention recently because of its key role in apoptosis and necrosis induced by physiological events such as hypoxia. The manner which mitochondria interact with other molecules to regulate mitochondrial cell destiny remains elusive. Previously we verified that hypoxia-induced phosphorylation microtubule-associated protein 4 (MAP4) could lead microtubules (MTs) disruption. In this study, established the hypoxic (1% O(2)) models...
Wound healing is a complex dynamic process involving large number of biological events. Excessive oxidative stress key factor delaying wound healing. Hydrogen an antioxidant, anti-inflammatory, and antiapoptotic medical gas with safety, effectiveness, penetrability. However, the effects local treatment hydrogen on its potential mechanisms remain unclear. In this study, Kunming (KM) mice were used to set up model. All randomly divided into control, saline group, hydrogen-rich intraperitoneal...
Abstract Background Due to vasculature injury and increased oxygen consumption, the early wound microenvironment is typically in a hypoxic state. We observed enhanced cell migration ability under short-term hypoxia. CCL2 belongs CC chemokine family was found be wounds enriched extracellular signal-regulated kinase (ERK)1/2 pathway our previous study. However, underlying mechanism through which CCL2-ERK1/2 regulates healing hypoxia remains unclear. Activation of epithelial–mesenchymal...
Neuroinflammation is a significant driving force in the pathogenesis and progression of central nervous system (CNS) disorders. Polymethoxylated flavones (PMFs), key lipid-soluble constituents Citri Reticulatae Pericarpium (CRP), exhibit excellent blood-brain barrier permeability anti-inflammatory properties, holding therapeutic potential for CNS However, specific bioactive components effects PMFs treating disorders are not well understood. This study employed comprehensive sequential...
Glioma is the most common primary intracranial tumor and associated with poor prognosis. Identifying effective biomarkers for glioma particularly important. MXRA5, a secreted glycoprotein, involved in cell adhesion extracellular matrix remodeling has been reported to be expressed many cancers. However, role mechanism of action MXRA5 gliomas remain unclear. This study was aimed at investigating transcriptome level its clinical prognostic value. In this study, RNA microarray data 301 patients...
Antibiotics-resistant
Abstract Benzalkonium bromide (BB) has been widely used as a skin antiseptic for wound management. However, BB had proinflammation and reactive oxygen species (ROS) induction effect, making its role in healing complex unclear. A rat full‐thickness defect model was established. The effects of BB, povidone iodine (PVP‐I), chlorhexidine gluconate (CHG), normal saline (NS) on infection control were then evaluated based rate (WHr) bacterial killing. tissues sectioned histopathological evaluation...
Silicone rubber (SR) is a common soft tissue filler material used in plastic surgery. However, it presents poor surface for cellular adhesion and suffers from biocompatibility. In contrast, hydroxyapatite (HA), prominent component of animal bone teeth, can promote improved cell compatibility, but HA an unsuitable because the brittleness mechanism. this study, using simple economical method, two sizes was applied to coat on SR counteract biocompatibility SR. Surface mechanical properties...
Medical device implants are drawing increasing amounts of interest from modern medical practitioners. However, this attention is not evenly spread across all such devices; most these implantable devices can cause adverse reactions as inflammation, fibrosis, thrombosis, and infection. In work, the biocompatibility silicone rubber (SR) was improved through carbon (C) ion implantation. Scanning electron microscopy (SEM), atomic force (AFM), X-ray photoelectron spectroscopy (XPS), diffraction...
Silicone rubber and silicone rubber-based materials have been used as medical tissue implants in the field of plastic surgery for many years, but there are still some reports adverse reactions to long-term implants. Earlier studies shown that ion implantation could enhance biocompatibility biomaterials. However, whether has a good effect on is unknown.Three types carbon were obtained by implanting three doses ions. Then, antibacterial adhesion properties vivo host responses evaluated. The...
Divalproex sodium extended-release tablet (divalproex-ER) is a novel formulation of the conventional divalproex delayed-release (divalproex). In five multiple-dose studies in healthy subjects (n=82) and epilepsy patients (n=86) estimates divalproex-ER/divalproex ratios for steady-state 24 h valproic acid area under curve (AUC) central values, maximum concentration (C(max)) values minimum (C(min)) means had ranges 0.77-0.97, 0.71-0.87 0.78-1.03, respectively. These used different regimens...
Background/Aims Microencapsulated hepatocytes have been proposed as promising bioactive agents for packed-bed or fluidized-bed bioartificial liver assist devices (BLADs) and hepatocyte transplantation because of the potential advantages they offer high mass transport rate an optimal microenvironment culture. We developed a large-scale high-production alginate-chitosan (AC) microcapsule roller bottle culture system encapsulation HepLL immortalized human hepatocytes. In this study, efficacy...