Mitochondrial membrane permeability has received considerable attention recently because of its key role in apoptosis and necrosis induced by physiological events such as hypoxia. The manner which mitochondria interact with other molecules to regulate mitochondrial cell destiny remains elusive. Previously we verified that hypoxia-induced phosphorylation microtubule-associated protein 4 (MAP4) could lead microtubules (MTs) disruption. In this study, established the hypoxic (1% O(2)) models...

Emulsified isoflurane (EIso) preconditioning can induce cardioprotection. We investigated whether EIso application after ischemia protects hearts against reperfusion injury and it is mediated by the inhibition of apoptosis. Rats were subjected to 30-min coronary occlusion followed 180-min reperfusion. At onset reperfusion, rats intravenously administered saline (sham, control group), 30 % intralipid (IL group) or 2 ml kg−1 (EIso for min. After infarct sizes, myocardial apoptosis expression...

In order to realize accurate marketing by analyzing customer individual demand, a new quantitative Kano model method is put forward, and it helpful provide customized products for heterogeneous classification groups. By improving the traditional model, satisfaction importance degree of are defined, demand established. Customers classified as price preference group, brand service priority decision-making product attribute quality improvement realized. Lastly, electric vehicles (EVs) selected...

Hypoxia-inducible factor (HIF)-1alpha is a key regulator of anaerobic energy metabolism. We asked the following question: Does breakdown microtubular structures influence glycolysis in hypoxic cardiomyocytes by regulating HIF-1alpha? Neonatal rat were cultured under conditions, while microtubule-stabilizing (paclitaxel) and -depolymerizing (colchicine) agents used to change structure. Models high microtubule-associated protein 4 (MAP4) expression RNA interference microtubulin established....

The solution strategy of the heuristic algorithm is pre-set and has good performance in conventional cloud resource scheduling process. However, for complex dynamic service tasks, due to difference attributes, efficiency a single low such problems. In this paper, we presents hyper-heuristic based on reinforcement learning (HHRL) optimize completion time task sequence. Firstly, reward table setting stage HHRL, introduce population diversity integrate maximum comprehensively determine...

The paper first introduces the requirements of cutting tool real-time status for MES application, and analyzes information tracking management process. And then studies key technology about system, including direct laser marking identifying acquiring in environment DNC. Lastly, thesis designs a system using object-oriented technology, realization page following J2EE mode.

The specific development process for SolidWorks standard parts library is studied based on VB by taking spiral wound gasket instance and the established in environment. users can insert needed 3-D modeling through form VB. Thus design simplified, efficiency improved.

Networked manufacturing is cooperative on the basis of various hierarchy resources sharing in its nature, and it takes form agile virtual enterprise (AVE). It's important to get optimum Cooperative scheme by analyzing, arranging evaluating capability candidate for manufacturing. The level machine tools main factor capability. paper analyzes art selection, introduces advantage selection based grey relation theory AHP method. Firstly, index system discussed according cost, time quality....

Journal Article Detection of Carbapenemase-Encoding Genes Among Clinical Isolates Pseudomonas aeruginosa in a Chinese Burn Unit Get access Feng-Jun Sun, Sun *Department Pharmacy, Southwest Hospital, the Third Military Medical University, Chongqing, People's Republic China Search for other works by this author on: Oxford Academic Google Scholar Hui-Qing Shi, Shi Xiao-Bing Zhang, Zhang †Department Laboratory Medicine, Ya-Dong Fang, Fang ‡Institute Research, Yong-Chuan Chen, Chen Jian-Hong Qian...

Abstract For parts with large deep-diameter ratio shaped hole features, the complex structure of profile and led to poor machining accuracy. The processing requires high efficiency, precision low cost. Therefore, it is difficult use traditional method, electrolysis method based on anodic dissolution mechanism adopted, which has no shear stress accurate forming. 3D model established part, cathode tooling designed. Based COMSOL software, we designed flow channel uniformity electrolytic holes...

The medical image management and analysis system proposed in this paper is a software developed by the Browser/Server (B/S) architecture after investigating workflow of relevant departments hospital, which realizes entire process patients from consultation to printing reports. computer-aided diagnosis function added based on management. Due difficulty collecting data, module, only uses common fungal keratitis collected hospital laboratory. Focused microscope images are used for experiments....

This paper summarily introduces principles of basic ant colony algorithm and explains the mathematical model through traveling salesman problem, then applications in discrete job-shop scheduling are expounded , mainly established method formation one-to-one relationship by path utilizing way which ants traverse processes workpieces scheduling. So objective function is optimized efficiency improved. Lastly, prospects applying to future work for this problem discussed.

To raise enterprise core competitiveness ability, this paper puts forward manufacturing-resource integration and a sharing ideal based on XML technology. It firstly analyzes the mechanism of manufacturing resource isomeric data, then discusses platform analysis designs, according to software engineer thought. Lastly, thesis introduces how describe information by technology gives file building parsing method.

To improve manufacturing capability of national defense industry, the paper brings forward cutting tool life-cycle management problem. And then studies its key technology, including resource classification and code etc.. Further more, The lastly analysis designs tools system through IDEF methodology gives page TLMS according to J2EE mode.

To improve enterprise manufacturing execution efficiency, the paper brings forward machine tools life-cycle management problem, and then discusses modeling technology. In order to integrate heterogeneous data of tools, introduces resource information integration platform based on XML Further more, lastly analysis designs system through IDEF methodology gives key page MLMS according J2EE mode.

Manufacturing execution system (MES) is put forward by advanced manufacturing research, and it's the management information for workshop hierarchy, which located between planning industry controlling system. How to manage, share allocate resource key problem MES. The paper firstly introduces requirements of allocation MES application, analyzes plant task description equipment model. And then studies optimization deployment based on grey relation theory ant colony algorithm. Secondly, divided...

Lacking the effective methods to reduce labor and cost, many small- medium-sized assembly companies are facing with problem of high cost for a long time. In order costs manual operations, method meta-mechanism combination replacement is studied. this paper, we mainly discuss assembling motion analysis, workpieces position information acquisition, library construction, analysis by Maynard’s operation sequence technique, database establishment, match mechanism. At same time, principle,...

Abstract To solve the problem of ergonomic evaluation suit production system, a hybrid method IAHP and gray entropy theory is proposed. Firstly, literature reviews for ergonomics tools techniques are introduced. Furthermore, index system operation established according to practice. Besides, comprehensive models process Finally, detailed sewing, ironing clipping introduced by an example, results show that paper helpful verify feasibility effectiveness improvement demonstration.

Abstract Robot cloud service platform is a combination of computing and robotics, providing intelligent services for many robots. However, to select that satisfys the robot’s requirements from massive with different QoS indicator in an NP hard problem. In this paper, based on cost model between platform, we propose two-stage selection strategy, namely, candidate stage according specific robots final optimization stage. Additionally, respect optimizing model, Dynamic Vector Hybrid Genetic...

Abstract Traditional electrochemical machining systems rely on sensors and control to achieve automated control. However, the process still requires human supervision, system cannot adapt changes based on-site conditions. This article proposes designs a digital CPS theory. The utilizes combination of simulation models before, adaptive during machining, data tracing after machining. Compared traditional methods, this can better current's stability, improving quality efficiency. Finally,...