A5100411056- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Folate and B Vitamins Research
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Neurogenetic and Muscular Disorders Research
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Diet and metabolism studies
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Sarcoma Diagnosis and Treatment
- Corneal surgery and disorders
- Mesenchymal stem cell research
- Traditional Chinese Medicine Analysis
- Dialysis and Renal Disease Management
- Cardiovascular Health and Disease Prevention
- Immunotherapy and Immune Responses
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2020-2024
Zhujiang Hospital
2019-2024
Southern Medical University
2019-2024
Dalian Medical University
2023-2024
Chongqing Medical University
2020-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Tongji University
2024
Shanghai Tenth People's Hospital
2024
Buddhist Tzu Chi General Hospital
2024
Abstract Previously we observed strong and consistent associations between vitamin B 6 status several indicators of inflammation in patients with rheumatoid arthritis. Clinical indicators, including the disability score, length morning stiffness, degree pain, biochemical markers, erythrocyte sedimentation rate C-reactive protein levels, were found to be inversely correlated circulating levels. Such imply that impaired these results from inflammation. In present study examined whether...
Abstract Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor outcomes and relapse risk prediction approaches have not changed significantly in decades. To build a robust transcriptional model for AML, we perform RNA-sequencing on 1503 primary diagnostic samples. While 17 gene stem cell signature (LSC17) predictive our aggregated study population, LSC17 no longer within established cytogenetic molecular (cytomolecular) groups. Therefore, identify distinct LSC...
Hindlimb ischemia (HLI), in which blood perfusion to the hindlimb is obstructed, one of major complications diabetes. Skeletal muscle cells are crucial for revascularization as they can secrete various angiogenic factors; however, hyperglycemia impairs their viability and subsequently potential. Salidroside promote skeletal cell under hyperglycemia; molecular mechanism still poorly understood. Here we revealed that salidroside could suppress hyperglycemia-induced ferroptosis by promoting...
Tendon injuries, a common musculoskeletal issue, usually result in adhesions to the surrounding tissue, that will impact functional recovery. Macrophages, particularly through their M1 and M2 polarizations, play pivotal role inflammatory healing phases of tendon repair. In this review, we explore macrophage polarization healing, focusing on insights from animal models. The review delves into complex interplay macrophages pathology, detailing how various phenotypes contribute both adhesion...
The mechanisms underlying the impact of pathophysiological elevations in insulin or glucose on hepatic cellular homocysteine kinetics is not fully understood.The objective study was to investigate elevated insulin/glucose at level.Effects and remethylation transsulfuration metabolic fluxes were investigated a cell model using stable isotopic tracers gas chromatography/mass spectrometry. methylation status assessed by S-adenosylmethionine (adoMet), adoMet S-adenosylhomocysteine ratio, DNA...
The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased risk of colon cancer although it may increase breast cancer. This changes intracellular folate cofactors, which affect DNA methylation and synthesis via altered one-carbon transfer reactions. We investigated effect this mutation on uracil misincorporation its interaction exogenous further modulating these biomarkers reactions an vitro model MTHFR 677T HCT116 MDA-MB-435 adenocarcinoma...
AIM:To investigate the effect and mechanism of blockade CXC chemokine receptor-4 (CXCR4) signaling pathway by AMD3100, a small non-peptide CXCR4 inhibitor, on invasion metastasis colorectal cancer cells in vitro . METHODS:Human cell line SW480 was treated with AMD3100 at different final concentrations.3-(4,5-dimethylthiazol-2-yl)-2.5-dipheny-tetrazoliumbromide (MTT) assay used to detect proliferation.The ability determined kit.In presence CXCL12-mediated migratory response tested classical...
Objectives Identifying patients at risk of a 30-day readmission can help providers design interventions, and provide targeted care to improve clinical effectiveness. This study developed model predict inpatient hospital for in Maine, across all payers, diseases demographic groups. Methods Our objective was develop determine the within 30 days post discharge. All Maine Health Information Exchange (HIE) system were included. The retrospectively on encounters between January 1, 2012 December...
Testis-specific PRSS55 is a highly conserved chymotrypsin-like serine protease among mammalian species. So far, the physiological function of remains unknown. Here, we show that GPI-anchored membrane protein, specifically expressed in adult mouse testis and mainly observed luminal side seminiferous tubules sperm acrosome. Mice deficient for Prss55 develop male infertile with normal reproduction-related parameters observed. Interestingly, vivo fertilization rate Prss55−/− males dramatically...
Methionine S-adenosyltransferase (MAT) catalyzes the only reaction that produces major methyl donor in mammals. Low-dose methotrexate is most commonly used disease-modifying antirheumatic drug human rheumatic conditions. The present study was conducted to test hypothesis inhibits MAT expression and activity vitro vivo. HepG2 cells were cultured under folate restriction or low-dose with without methionine supplementation. Male C57BL/6J mice received regimens reflected clinical use humans....
Abstract Background Acute myeloid leukemia (AML) with megakaryocytic differentiation (AMkL) is a rare subtype of AML more common in children. Recent literature has identified multiple fusions associated this type leukemia. Methods Morphology, cytogenetics, and genomic sequencing were assessed patients from Children's Oncology Group trials AAML0531 AAML1031 central‐pathology review confirmed non‐Down syndrome AMkL. The 5‐year event‐free survival (EFS), overall (OS), RR evaluated these AMkL...
Depression is of increasing concern as its prevalence increases. Our study’s objective was to create and evaluate a nomogram predict the likelihood that hypertension patients may experience depression. 13293 people with who were under 20 years old chosen from National Health Nutrition Examination Survey (NHANES) database between 2007 2018 for this study. The training validation sets split up into dataset at random in 7:3 ratio. To find independent predictors, univariate multivariate logistic...
The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent via a temporary hemodialysis (HD) catheter has rarely been evaluated within full spectrum treated end-stage renal disease (ESRD). We investigated the longer-term outcomes patients undergoing emergent-start PD in comparison with that other practices or HD prospective cohort new-onset ESRD. This was 2-year observational study. enrolled 507 incident ESRD patients, among them 111 chose (43 planned-start, 68...
Background: Chemotherapy resistance is one of the main causes clinical chemotherapy failure. Current cancer research explores drug mechanism and new therapeutic targets. This work aims to elucidate thyroid hormone receptor interactor 13 (TRIP13) affecting doxorubicin (DOX) in colorectal (CRC). Methods: Bioinformatics analyses were employed clarify TRIP13 expression CRC tissues predict correlation enrichment pathway with glycolysis-related genes stemness index mRNAsi. Quantitative real-time...
Protein aggregation caused by the disruption of proteostasis will lead to cellular cytotoxicity and even cell death, which is implicated in multiple neurodegenerative diseases. The elimination aggregated proteins mediated selective macroautophagy receptors, termed aggrephagy. However, identity redundancy aggrephagy receptors recognizing substrates remain largely unexplored. Here, we find that CCDC50, a highly expressed autophagy receptor brain, recruited proteotoxic stresses-induced...