A5029264192- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Stress Responses and Cortisol
- Extracellular vesicles in disease
- Neuroendocrine regulation and behavior
- Colorectal Cancer Surgical Treatments
- Tissue Engineering and Regenerative Medicine
- Hormonal Regulation and Hypertension
- Ultrasound and Hyperthermia Applications
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Oral health in cancer treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Frailty in Older Adults
- Thermal Regulation in Medicine
- MicroRNA in disease regulation
- Enhanced Recovery After Surgery
- Anorectal Disease Treatments and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Plant-based Medicinal Research
- Wound Healing and Treatments
Institut de Radioprotection et de Sûreté Nucléaire
2007-2023
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2004-2020
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2004
Inserm
1999-2000
Roche (Switzerland)
2000
Institut de Neurobiologie de la Méditerranée
1999
Mesenchymal stem cells (MSCs) have been shown to migrate various tissues. There is little information on the fate and potential therapeutic efficacy of reinfusion MSCs following total body irradiation (TBI). We addressed this question using human MSC (hMSCs) infused nonobese diabetic/ severe combined immunodeficient (NOD/SCID) mice submitted TBI. Further, we tested impact additional local (ALI) superimposed TBI, as a model accidental irradiation. NOD/SCID were transplanted with hM-SCs. Group...
The therapeutic potential of bone marrow-derived human mesenchymal stem cells (hMSC) has recently been brought into the spotlights many fields research. One possible application approach is repair tissue injuries related to side effects radiotherapy. first challenge in cell therapy assess quality and ability retain their differentiation during expansion process. Efficient delivery sites intended action also necessary. We addressed both challenges using hMSC cultured then infused non-obese...
Patients who undergo pelvic radiotherapy may develop severe and chronic complications resulting from gastrointestinal alterations. The lack of curative treatment highlights the importance novel effective therapeutic strategies. We thus tested benefit mesenchymal stem cells (MSC) proposed molecular mechanisms action. MSC efficacy was in an experimental model radiation-induced colonic ulceration histologically similar to that observed patients. In this model, bone marrow were administered...
Abstract Background Human exposure to high doses of radiation resulting in acute syndrome and death can rapidly escalate a mass casualty catastrophe the event nuclear accidents or terrorism. The primary reason is that there presently no effective treatment option, especially for radiation-induced gastrointestinal syndrome. This results from disruption mucosal barrier integrity leading severe dehydration, blood loss, sepsis. In this study, we tested whether extracellular vesicles derived...
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able encapsulate and withstand Ad-MSCs, overcome these limitations. A silanized hydroxypropylmethyl...
Abstract Radiation proctitis is an insidious disease associated with substantial morbidity and mortality. It may develop following the treatment of several cancers by radiotherapy when normal colorectal tissues are present in irradiation field. There no unified approach for assessment this disease, partly due to insufficient knowledge about mechanism involved development radiation proctitis. However, unresolved inflammation hypothesized have important role late side effects. This study aimed...
Every year, millions of people around the world benefit from radiation therapy to treat cancers localized in pelvic area. Damage healthy tissue field can cause undesirable toxic effects leading gastrointestinal complications called disease. A change composition and/or function microbiota could contribute radiation-induced toxicity. In this study, we tested prophylactic effect a new generation probiotic like Faecalibacterium prausnitzii (F. prausnitzii) on acute colonic lesions. Experiments...
Abstract: The raphe‐hippocampal serotonin (5‐HT) system is involved in the regulation of hypothalamuspituitary‐adrenal axis. purpose this study was to determine and compare roles 5‐HT glucocorticoid receptor (GR) binding raphe nuclei hippocampus. effects 5‐HT, agonists, reuptake inhibitor citalopram on GR sites were studied primary cultures fetal Exposure hippocampal cells (±)‐2,5‐dimethoxy‐4‐iodoamphetamine (DOI; a 2 agonist), or resulted an increase number sites. effect DOI blocked by...
Many studies have shown the existence of functional interactions between central neurotransmitter systems and hypothalamo-pituitary adrenal axis. Mineralocorticoid receptors (MR) glucocorticoid (GR) are regulated by multiple factors including glucocorticoids themselves. Neurotransmitters such as serotonin (5-hydroxytryptamine: 5-HT) can regulate brain corticosteroid in a complex way. The present study examined short-term (48 h) effects parachlorophenylalanine (PCPA), drug which specifically...
Alterations of the hypothalamic‐pituitary‐adrenal (HPA) axis function characterized by a decreased negative feedback capacity are often associated with affective disorders and corrected treatment antidepressant drugs. To gain better understanding effects drug fluoxetine, specific serotonin (5‐HT) reuptake inhibitor, on central corticosteroid receptors, short‐term activation transmission receptor expression were analysed in adrenalectomized (ADX) rats either supplemented or not...
In Brief Each year, millions of people worldwide are treated for primary or recurrent pelvic malignancies, involving radiotherapy in almost 50% cases. Delayed development visceral complications after is recognized cancer survivors. Therapeutic doses radiation may lead to the damage healthy tissue around tumor and abdominal pain. Because lack experimental models, underlying mechanisms radiation-induced long-lasting pain still unknown. This makes managing difficult, therapeutic strategies...
Transgenic (TG) mice deficient in glucocorticoid receptors (GR) were used order to study the effects of a reduced GR function on adrenocorticotropin hormone and corticosterone plasma levels serotonin metabolism different brain areas under basal resting conditions, after 30-min restraint stress 60 min end stress. There was no difference or stress-induced either control TG mice, but return values delayed mice. Under ratio 5-hydroxyindoleacetic acid/5-hydroxytryptamine decreased only...
De nombreuses études suggèrent que les cellules souches adultes et plus particulièrement Mésenchymateuses humaines (CSMh) pourraient être utilisées pour réparer de nombreux organes.Nous avons étudié la capacité des CSMh à réduire lésions cutanées radio induite.Pour induire sévères peau, souris NOD/SCID ont été irradiées au niveau patte droite postérieure (30 Gy, débit 2,7 Gy/mn) en utilisant une source gamma 60 Co.Les injectées 24 heures après irradiation par voie intraveineuse.La présence...
Abstract Background: Human exposure to high doses of radiation resulting in acute syndrome and death can rapidly escalate a mass casualty catastrophe the event nuclear accidents or terrorism. The primary reason is that there presently no effective treatment option, especially for radiation-induced gastrointestinal syndrome. This results from disruption mucosal barrier integrity leading severe dehydration, blood loss sepsis. In this study, we tested whether extracellular vesicles derived...
Abstract Background The estimated increase in prevalence of radiation enteropathy associated with a current scarcity effective treatment options underline the need for development new therapies. Extracellular vesicles (EV), which are membrane-bound particles secreted by cells containing proteins, lipids and nucleic acids, have yielded promising preclinical results various applications regenerative medicine. Here, we aimed to investigate whether EV from adipose-derived stromal (ADSC) may...
The present work was initiated in an effort to evaluate the potential therapeutic contribution of infusion MSC for correction liver injuries.We subjected NOD-SCID mice a 10.5 Gy abdominal irradiation and we tested biological histological markers injury absence after expanded human MSC.Irradiation alone induced significant elevation transaminases (ALT AST).Apoptosis endothelial layer vessels observed.When were infused mice, decrease measured, total disappearance apoptotic cells.MSC not found...