A5100406126- Immune Cell Function and Interaction
- interferon and immune responses
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Aquaculture disease management and microbiota
- S100 Proteins and Annexins
- Immunotherapy and Immune Responses
- Microbial infections and disease research
- Viral Infections and Vectors
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Reproductive System and Pregnancy
- Invertebrate Immune Response Mechanisms
- Diet, Metabolism, and Disease
- Indoor Air Quality and Microbial Exposure
- Macrophage Migration Inhibitory Factor
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- IgG4-Related and Inflammatory Diseases
- Immunotoxicology and immune responses
- Protein Tyrosine Phosphatases
- Ferroptosis and cancer prognosis
- Psoriasis: Treatment and Pathogenesis
Soochow University
2023-2025
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Southern Medical University
2024
Jiangsu University of Science and Technology
2024
Hunan University of Traditional Chinese Medicine
2024
Second People Hospital of Hunan
2024
Fujian Medical University
2024
Renji Hospital
2023
Shanghai Jiao Tong University
2023
RNA virus infection usually triggers a range of host immune responses, including the induction proinflammatory cytokines, interferons, and interferon-stimulated genes (ISGs). Here, we report that UBL7, ubiquitin-like protein, is upregulated during induced by type I interferon as an ISG. UBL7-deficient mice exhibit increased susceptibility to viral due attenuated antiviral innate immunity. UBL7 enhances response promoting K27-linked polyubiquitination MAVS. interacts with TRIM21, E3 ubiquitin...
Objective: Recurrent implantation failure (RIF) is now disturbing numerous infertile couples accepting assisted reproductive technology (ART). And the endometrial factors are crucial causes of recurrent failure. However, its mechanism still unclear. Thus, aim this study to identify altered biologic processes in endometrium that may contribute Methods: We recruited two microarray datasets (GSE103465, GSE111974) from Gene Expression Omnibus database (GEO), which contain RIF and normal women...
Neutrophils are considered to be crucial players in the initiation and progression of cancer. However, complex relationship between neutrophils cancer prognosis remains elusive, mainly due significant plasticity diversity exhibited by these immune cells.
Crucian carp ( Carassius auratus ) is one of the major freshwater species and also a common food fish in China. Recently, herpesvirus (CaHV) could induce fatal viral disease with high mortality crucian carp, which had caused huge economic losses. In this study, we described rapid simple recombinase-aid amplification (RAA) assay coupled lateral flow dipstick (LFD), achieve sensitive diagnosis tumor necrosis factor receptor (TNFR) CaHV within 35 min at 40°C. Our RAA-LFD method satisfactory...
BACKGROUND Tripartite motif containing 55 (TRIM55) plays a regulatory role in assembly of sarcomeres, but few studies have assessed its function hepatocellular carcinoma (HCC). MATERIAL AND METHODS Immunohistochemistry (IHC) was used to detect expression TRIM55 tissues samples HCC patients. Transwell assay study migration and invasion ability cells. Western blot immunofluorescence (IF) were analyze mechanism cell invasion. RESULTS We found downregulated associated with prognosis Cox...
PCR-based DNA amplification has been one of the major methods in aquaculture research for decades, although its use outside modern laboratory environment is limited due to relatively complex and high costs. To this end, we investigated a swabbing disc protocol collection samples from fish which could extract skin mucus by non-invasion technique costing only $0.02 (USD) requiring less than 30 seconds. The method that chose cheap filter paper above 104 crucian carp blood cells, comparable...
This study aims to elucidate the role and mechanisms of Death Receptor 6 (DR6), a member tumor necrosis factor receptor superfamily, in malignant progression colorectal cancer (CRC). The association DR6 expression levels CRC patient survival was examined using cohort data from GEPIA database. functional cells investigated by performing loss-of-function gain-of-function experiments based on CCK-8 proliferation assay, transwell migration invasion sphere-forming assays. Xenograft model nude...
This study was conducted to determine the diagnosis and genotype of Orientia tsutsugamushi in Pinggu district, Beijing. Indirect immunofluorescence assay (IFA) performed detect O. -specific immunoglobulin M (IgM) G (IgG) antibodies. Nested polymerase chain reaction (PCR) DNA sequencing analysis targeting groEL gene 56 kDa protein were on whole-blood samples from scrub typhus patients. We confirmed that 47 patients infected with Representative sequences amplified by primers according...
The mechanisms underlying sepsis-induced cardiomyopathy (SIC) remain poorly understood, and there are no specific therapeutics for SIC. We investigated the effects of maresin conjugates in tissue regeneration 1 (MCTR1) on SIC explored its potential mechanisms. experiments were conducted using an endotoxemia model induced by lipopolysaccharide (LPS). Mice given MCTR1 intravenously 6 h after LPS stimulation. Echocardiography was performed to assess cardiac function 12 administration. Treatment...
This study investigated the effects of different dietary arginine (Arg) levels on growth, protein synthesis, antioxidant capacity, and immunity postlarval mud crab Scylla Paramamosain . Six isonitrogenous isolipidic diets were formulated to contain 1.51%, 1.81%, 2.16%, 2.35%, 2.73%, 3.07% Arg (dry matter). There four replicates for each diet treatment (26 crabs per replicate, initial body weight: 7.40 ± 0.15 mg). After eight weeks feeding trial, survival molting frequency (MF) not affected...
Background: Hepatocellular Carcinoma (HCC) is a common lethal digestive system tumor. The oxidative stress mechanism crucial in the HCC genesis and progression. Methods: Our study analyzed single-cell bulk sequencing data to compare microenvironment of non-tumor liver tissues tissues. Through these analyses, we aimed investigate effect on cells identify critical response-related genes that impact survival patients. Results: results showed increased tissue compared tissue. Immune exhibited...
Liver transplantation and liver resection are curative options for early hepatocellular carcinoma (HCC). The outcome is in part depended on the immunological response to malignancy. In this study, we aimed identify profiles of non-HCV/non-HBV HCC patients.Thirty-nine immune cell subsets were measured with multicolor flow cytometry. This immunophenotyping was performed peripheral blood (PB) tumor specimens 10 patients healthy donors. signatures highly differential leukocyte count (hDIF)...
The current influenza vaccines are unable to provide effective protection in many cases, like viruses strain antigenic drift or shift, and the continues cause significant annual morbidity mortality. Improving immune response vaccination is an unmet need. Traditional Chinese medicine (TCM) its active ingredients commonly known have immunomodulatory properties. We therefore compared alone formulated with Astragali Radix (Huangqi Chinese), several representative of TCM, including lentinan...
Objective To investigate the active ingredients, underlying anti-influenza virus effects, and mechanisms of Huoxiang Suling Shuanghua Decoction (HSSD). Materials methods The therapeutic effect HSSD were confirmed through survival rate experiment H1N1-infected mice. Then, solution ingredients absorbed into blood after treatment with in rats identified by UPLC/Q-TOF MS, while main contents detected high performance liquid chromatography (HPLC). Next, a systems pharmacology approach...