A5081406822- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Organic and Inorganic Chemical Reactions
- Synthesis of heterocyclic compounds
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Characterization of Pyrroles
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Free Radicals and Antioxidants
- Synthesis of Organic Compounds
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Organophosphorus compounds synthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
Sri Venkateswara University
2014-2024
KLS Gogte Institute of Technology
2024
Bridge University
2021
Indian Institute of Technology Tirupati
2018
Icahn School of Medicine at Mount Sinai
2011
Temple University
2004-2005
University of the Punjab
2003
Shri Venkateshwara University
2002
Pondicherry University
1990
Cyclin D proteins are elevated in many cancer cells, and targeted deletion of cyclin D1 gene the mammary tissues protects mice from breast cancer. Accordingly, there is an increasing awareness this novel nonenzymatic target for therapeutics. We have developed novel, nonalkylating styrylbenzylsulfones that induce cell death wide variety cells without affecting proliferation survival normal cells. The development derivatized followed logically a tumor cytotoxicity screen performed our...
The interactions between substituted 5-<italic>R</italic>-3-(pyridyl-2)-1,2,4-triazines with <italic>in situ</italic> generated aryne intermediates have been studied.
A new class of amido sulfonamido methane linked bis heterocycles- bis-oxazoles, thiazoles and imidazoles were prepared screened for antimicrobial anticancer activities. The chloro substituted bisimidazole exhibited excellent activity also it was the most potent compound on lung, colon prostate cancer cell lines.
A new class of bis heterocycles‐benzimidazolyl pyrazoles were prepared from the Michael acceptor ( E )‐3‐(1 H ‐benzimidazol‐2‐yl)‐1‐aryl‐prop‐2‐en‐1‐one. The thiamide group was exploited to develop thiazole ring on treatment with p ‐fluorophenacyl bromide get tris heterocycles. All lead compounds tested for antimicrobial activity. compound 7d having nitro substituent aromatic showed greater activity particularly against Pseudomonas aeruginosa and P enicillium chrysogenum .
A new class of sulfone-linked bis heterocycles, methyl-3-(4′-aryl-1′H-pyrazol-3′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (8), methyl-3-(1′-phenyl-3′,5′-diaryl-1′H-pyrazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (9) and methyl-3-(3′,5′-diarylisoxazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (10) were prepared by the regioselective reaction methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate (2) with tosylmethyl isocyanide followed fuctionalization olefin moiety 1,3-dipolar...
The α-keto methylene group in 3,5-diaryl-2-cyclohexenones 2 and 3,5-diarylcyclohexanones 8 have been used to obtain fused pyrazoles isoxazoles. new compounds were characterized by IR 1H-NMR spectral data.
A new class of mono- and bis-heterocycles, 2-arylsulfonylaminosulfonylmethyl-5-styrylsulfonylmethyloxadiazoles, pyrazolyl oxadiazoles, isoxazolyl were synthesized tested for their antioxidant activity. The styrylsulfonylmethyloxadiazole 5b showed good activity when compared with the standard ascorbic acid.