A5068780638- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Bone health and osteoporosis research
- Pulmonary Hypertension Research and Treatments
- Bone fractures and treatments
- Electrical and Bioimpedance Tomography
- Sepsis Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Sulfur Compounds in Biology
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Cardiovascular Health and Disease Prevention
- Mesenchymal stem cell research
- Heart Rate Variability and Autonomic Control
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Ultrasound in Clinical Applications
- Mast cells and histamine
- Cancer Treatment and Pharmacology
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Plant-based Medicinal Research
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Thermal Regulation in Medicine
University of Rostock
2013-2025
University Hospital and Clinics
2017-2024
University Medical Center
2017-2024
Universität Ulm
2018
This study evaluates the effect of H2S donor GYY4137 (GYY) on adhesion molecule expression, protein S-sulfhydration and morphology platelets in vitro kinetics microvascular thrombus formation vivo. Using flowcytometry, untreated resting, TRAP-activated, or TRAP-activated GYY-exposed human were studied for expression P-selectin, GPIb GPIIb/IIIa as well fibrinogen binding. By means electron microscopy, platelet intracellular granule numbers assessed. Platelet shape change was using...
IntroductionHydrogen sulfide (H2S) known as a gasotransmitter is increasingly recognized for its anti-adhesive, anti-inflammatory and vasoactive properties. Due to these properties, we analysed anti-thrombotic effects of H2S the participation nitric oxide synthase (NOS)-pathway.Materials MethodsIn individual venules ear hairless SKH1-hr mice, thrombus formation was induced using phototoxic light/dye-injury model intravital fluorescence microscopy. Animals were treated intravenously with...
Postmenopausal females display a chronic inflammatory phenotype with higher levels of circulating pro-inflammatory cytokines. Furthermore, the response to injury may be altered under estrogen-deficiency, because it was shown previously that estrogen-deficient mice displayed increased cytokines Midkine (Mdk) and Interleukin-6 (IL-6) in early fracture hematoma. Because balanced immune is required for successful bone regeneration, this might contribute delayed healing frequently observed...
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) has a lasting impact on quality of life with high prevalence and the lack preventive causal treatment options. In addition, they are often dose-limiting for curative palliative oncological therapy. The aim this study was to systematically investigate occurrence paclitaxel-induced microcirculatory dysfunction its potential using an experimental in vivo approach. 77 female 8-week-old mice were randomly assigned into three groups. Each...
Abstract Respiratory failure due to SARS-CoV-2 may progress rapidly. During the course of COVID-19, patients develop an increased respiratory drive, which induce high mechanical strain a known risk factor for Patient Self-Inflicted Lung Injury (P-SILI). We developed novel Electrical Impedance Tomography-based approach visualize Dynamic Relative Regional Strain (DRRS) in positive and compared these findings with measurements lung healthy volunteers. DRRS was defined as ratio tidal impedance...
Abstract Background Gravity‐dependent positioning therapy is an established concept in the treatment of severe acute respiratory distress syndrome and improves oxygenation spontaneously breathing patients with hypoxemic failure. In coronavirus disease 2019, this seems to be less effective. Electrical impedance tomography as a point‐of‐care functional imaging modality for visualizing regional ventilation can possibly help identify who might benefit from guide those maneuvers real‐time....
Mice are extensively used for experimental bone-healing studies. However, there few established nondestructive in vivo techniques longitudinal fracture-healing analysis mice, including micro-computed tomography (μCT) and radiography. Importantly, none of the methods can discriminate between non-mineralized fibrous tissue cartilage soft fracture callus. Therefore, objective was to establish high-resolution magnetic resonance imaging (MRI) assessment callus formation during bone healing mice....
Abstract Objective . Since pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases it was suggested a potential non-invasive surrogate for PAP. The state of tidal lung filling is also known to affect PWTT independently aim this retrospective analysis test whether respiratory gating improved the correlation coefficient between and Approach In each one five anesthetized mechanically ventilated pigs two high-fidelity catheters were placed, directly behind valve,...
Microcirculatory disturbances can contribute to organ dysfunction in patients undergoing major surgeries and critical illness. Incident dark field imaging (CytoCam, Braedius Medical BV, Huizen, Netherlands) provides direct visualization of the microcirculation. To utilize this method daily clinical practice, automated image analysis is essential. This study aims compare recorded microcirculation video sequences using CytoCamTools V2 Analysis Manager (Braedius BV) with established manual...
For the non-invasive assessment of pulmonary artery pressure (PAP), surrogates like pulse wave transit time (PWTT) have been proposed. The aim this study was to invasively validate for which kind PAP (systolic, mean, or diastolic) PWTT is best surrogate parameter. To assess both and in six healthy pigs, two Mikro-Tip™ catheters were inserted into vasculature at a fixed distance: one trunk, second distal segment artery. raised using thromboxane A2 analogue U46619 (TXA) by hypoxic...
Pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases and was therefore suggested a surrogate parameter for PAP. The aim of this analysis to reveal patterns potential mechanisms ventilation-induced periodic changes in PWTT under resting conditions. To measure both PAP five healthy pigs, two Mikro-Tip™ catheters were inserted into the vasculature: one with tip placed trunk, second distal segment artery. Animals received pressure-controlled mechanical...
Endochondral fracture healing is a complex process involving the development of fibrous, cartilaginous, and osseous tissue in callus. The amount different tissues callus provides important information on progress. Available vivo techniques to longitudinally monitor preclinical fracture-healing studies using small animals include digital radiography µCT imaging. However, both are only able distinguish between mineralized non-mineralized tissue. Consequently, it impossible discriminate...
Pulse pressure variation (PPV) and stroke volume (SVV), which are based on the forces caused by controlled mechanical ventilation, commonly used to predict fluid responsiveness. When PPV SVV were introduced into clinical practice, volume-controlled ventilation (VCV) with tidal volumes (VT) ≥ 10 ml kg- 1 was most used. Nowadays, lower VT use of pressure-controlled (PCV) has widely become preferred type ventilation. Due their specific flow characteristics, VCV PCV result in different airway...