A5023586929- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Oral Health Pathology and Treatment
- Oral and gingival health research
- HIV/AIDS oral health manifestations
- Dental Radiography and Imaging
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- Endodontics and Root Canal Treatments
- Protease and Inhibitor Mechanisms
- Dental Erosion and Treatment
- Temporomandibular Joint Disorders
- Liver Disease Diagnosis and Treatment
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Biomarkers in Disease Mechanisms
- Mesenchymal stem cell research
- Hepatitis C virus research
- Laser Applications in Dentistry and Medicine
- Rheumatoid Arthritis Research and Therapies
- Medical and Biological Sciences
- S100 Proteins and Annexins
- Oral health in cancer treatment
University of Medicine and Pharmacy of Craiova
2015-2025
University of Craiova
2012-2021
University of Dental Medicine
2018
To improve the clinical and microbiological outcomes of non-surgical mechanical periodontal therapy, adjunctive use antimicrobials has been utilized in treating moderate-to-severe periodontitis. In our study, retrospective design included previously collected health-related patient data, obtained from printed digital charts patients who received systemic or local antibiotic adjuncts to SI (subgingival instrumentation). A total 34 (diagnosed with generalized Stage III/IV periodontitis) met...
In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features pathogenetic events similar to periodontitis (CP). The purpose of this study was evaluate utility determining systemic crevicular levels metalloproteinase-9 (MMP-9) potential biomarkers for association CP. A total fifty-six patients were included in study. subjects categorized...
(1) Background: The aim of this split-mouth design study was to analyze the clinical periodontal indexes and oxidative stress markers in gingival crevicular fluid modifications after three disease treatment possibilities (scaling root planning—SRP; SRP diode laser—L; photodynamic therapy—PDT). (2) Methods: conducted on 52 patients: systemically healthy subjects with disease—non-RA (n = 26); test group 26) rheumatoid arthritis disease—RA. Clinical measurements (probing depth—PD; Löe Silness...
Dental extraction can trigger certain sequences of complex processes that involve both hard (alveolar bone) and soft tissue (periodontal ligament, gingiva) remodeling. Type 2 diabetes is a serious risk factor for many oral pathologies, in terms progression severity, but also regarding subsequent rehabilitation possibilities. The aim this study was to establish whether molecules: osteoprotegerin (OPG), kappa B nuclear receptor activator ligand (RANKL), hepatocyte growth (HGF), tumor necrosis...
Periodontitis is a common condition affecting the tissues surrounding and supporting teeth. In addition to oral health concerns, periodontal disease increases chance of developing systemic illnesses including type 2 diabetes mellitus. Porphyromonas gingivalis, key-stone pathogen that has been linked pathophysiology disease, can generate series dipeptide producing exopeptidases, dipeptidyl peptidases (DPP). DPP-4 levels in gingival crevicular fluid have shown increase during active which may...
(1) Background: This cross-sectional investigation appreciated the role of serum C-reactive protein (CRP), several hematologic-cell markers, and salivary inflammation-related molecules [calprotectin (S100A8/A9), interleukin-1β (IL-1β), kallikrein] to predict periodontitis in patients with atherosclerotic cardiovascular disease (ACVD), arrhythmia, or both. Also, we relationship between inflammatory burden periodontal destruction type cardiac pathology. (2) Methods: Demographic, behavioral...
Background: This cross-sectional analytical study evaluates oral hygiene and periodontal status in patients with hypertension, given the established link between cardiovascular diseases poor health. Methods: A total of 24 hypertensive (15 male; 9 female) 30 healthy controls (19 11 from Craiova, Romania, were assessed using Periodontal Probing Depth (PPD), Plaque Index (PLQ), Bleeding on (BPI). Results: The mean age was 62.2 years group 47.4 control group. Oral poorer (PLQ: 73% vs. 24.1%...
Background/Objectives: Periodontitis, a prevalent chronic inflammatory disease affecting tooth-supporting structures, has been increasingly linked to systemic conditions such as diabetes mellitus (DM) and cardiovascular diseases (CVDs). This study aimed evaluate the periodontal status levels of dipeptidyl peptidase-4 (DPP-4) galectin-3 (Gal-3) in gingival crevicular fluid (GCF) patients with periodontitis, heart failure (HF), diabetes, exploring their potential biomarkers for association....
To measure the levels of pentraxin-3 (PTX-3) in gingival crevicular fluid (GCF) orthodontic young and adult patients first 2 weeks after appliance to determine whether those changes occur during treatment if values could be expression an inflammatory state.GCF samples were collected with paper strips from 16 13 upper canine requiring distalization as a test tooth. A contralateral was used control The absorbed volume eluted 100 µL phosphate-buffered saline (pH = 7.2). PTX-3 GCF determined...
Abstract Resin composite‐based dental materials can leach certain components into the oral environment, causing potentially harmful gingival biological effect. Gingival tissue is a rich source of mesenchymal stem cells (MSCs) that easily accessible, and be used as complementary approach for investigation material biocompatibility. Using MSCs (gMSCs), present study aimed to investigate cytotoxicity two classes restorative (ormocers resin composites) restore class II cavities close margin, in...
Background and objectives: this study aims to evaluate the clinical microbiological effects of a single subgingival administration locally delivered antibiotic gel containing piperacillin plus tazobactam compare it with slow-release doxycycline (14%) placebo gel, following instrumentation (SI) in patients severe periodontitis. Materials methods: sixty-four diagnosed stage III–IV periodontitis were enrolled, randomly assigned into three groups, treated additionally (group A); B); C). The...
(1) Background: This study aimed to assess the periodontitis burden in systemic sclerosis patients and possible association between them, degree which some potential risk factors two diagnostic biomarkers may account for this association. (2) Methods: cross-sectional included a test group (systemic patients) control (non-systemic patients). Both groups benefited from medical, periodontal examination saliva sampling determine salivary flow rate inflammatory (calprotectin, psoriasin). A...
Objectives: This randomized, placebo-controlled, double-masked clinical trial aimed to evaluate the and microbiological efficacy of professional mechanical plaque removal (PMPR) with or without adjunctive application piperacillin plus tazobactam gel in treatment peri-implant mucositis (PiM) for up 6 months. Materials Methods: The study included 31 patients (bleeding on probing (BoP) > 1 at least one site baseline, absence bone loss compared a previous radiograph). After randomized...
The study assessed whether the increased production of interleukin-1α (IL-1α) and interleukin-1β (IL-1β), as a result chronic hepatic inflammation, could be expression negative impact on periodontal disease. included periodontitis patients who were systemically healthy, suffering from hepatitis C, well control patients, being periodontally healthy. After examination assessment certain parameters, gingival crevicular fluid was collected all participating patients. By using enzyme-linked...
The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of NLRP3 inflammasome, caspase-1 (CASP-1), interleukin-18 (IL-18) evaluating whether increased local inflammatory reaction with clinical consequences correlated to their upregulation. Patients were divided into four groups, according status previously diagnosed C, as follows: (i) CHC group, patients; (ii) P patients, systemically healthy; (iii) + patients...