A5048047013- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Advanced Control Systems Optimization
- Advanced Control Systems Design
- Control Systems and Identification
- Real-time simulation and control systems
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Sensor Technology and Measurement Systems
- Vitamin D Research Studies
- Physical Activity and Health
- Muscle activation and electromyography studies
- Biotin and Related Studies
- Iterative Learning Control Systems
- Nutrition and Health in Aging
- Metalloenzymes and iron-sulfur proteins
- Structural Health Monitoring Techniques
- Genetics and Physical Performance
- Nanotechnology research and applications
- Industrial Automation and Control Systems
- Experimental Learning in Engineering
- Male Breast Health Studies
- Infrared Thermography in Medicine
- Engineering Applied Research
Karolinska Institutet
2013-2023
Karolinska University Hospital
2013-2023
Lund University
1990-2017
Helsingborgs lasarett
2017
Presence of the vitamin D receptor and direct effects on proliferation differentiation muscle precursor cells have been demonstrated in animal models. However, mechanisms actions human skeletal muscle, presence adult remain to be established. Here, we investigated role at various stages differentiation. We demonstrate that components D-endocrine system are readily detected but low nondetectable lack ability convert inactive D-metabolite 25-hydroxy-vitamin D3 active 1α,25-dihydroxy-vitamin...
Regular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week-1 or more) PA guidelines is very poor. A practical and time-efficient regime that was equally efficacious at controlling factors for cardio-metabolic disease one solution this problem. Herein, we evaluate a new genuinely high-intensity interval training (HIT) protocol in men women with pre-existing diabetes.One hundred eighty-nine sedentary (n = 101) 88) impaired...
This study tested the hypothesis that high doses of anti-inflammatory drugs would attenuate adaptive response to resistance training compared with low doses.Healthy men and women (aged 18-35 years) were randomly assigned daily consumption ibuprofen (IBU; 1200 mg; n = 15) or acetylsalicylic acid (ASA; 75 16) for 8 weeks. During this period, subjects completed supervised knee-extensor where one leg was subjected maximal volitional effort in each repetition using a flywheel ergometer (FW),...
Skeletal muscle weakness in patients suffering from rheumatoid arthritis (RA) adds to their impaired working abilities and reduced quality of life. However, little molecular insight is available on associated with RA. Oxidative stress has been implicated the disease pathogenesis Here we show that oxidative post-translational modifications contractile machinery targeted actin result polymerization force production. Using mass spectrometry, identified residues by 3-nitrotyrosine (3-NT) or...
The interactions between nutritional supplementation and physical activity on changes in function among older adults remain unclear. primary objective of this study was to examine the impact plus structured 400M walk capacity mobility-limited across two sites (Boston, USA Stockholm, Sweden).
Background Nutritional supplementation and structured physical activity have been shown to positively influence muscle mass strength in older adults. The efficacy of long‐term nutritional combination with this population remains unclear. Objective To examine the effects a combined intervention compared placebo, on measures total‐body thigh composition knee extensor cohort mobility‐limited adults across two sites (Boston, MA, USA Stockholm, Sweden). Design Mobility‐limited (Short Physical...
This study compared the effects of most frequently employed protocols flywheel (FW) versus weight-stack (WS) resistance exercise (RE) on regional and muscle-specific adaptations knee extensors. Sixteen men (n = 8) women performed 8 weeks (2-3 days/week) extension RE employing FW technology 1 leg (4 × 7 repetitions), while contralateral regular WS training 8-12 repetitions). Maximal strength (1-repetition maximum (1RM) in WS) peak power were determined before after for both legs. Partial...
Abstract This study aimed to validate a fully automatic method quantify knee-extensor muscle volume and exercise-induced hypertrophy. By using magnetic resonance imaging-based fat-water separated two-point Dixon sequence, the agreement between automated manual segmentation of specific ~15-cm region (partial volume) quadriceps was assessed. We then explored sensitivity technique detect changes in both complete partial response 8 weeks resistance training 26 healthy men women. There very...
We have previously shown that maximal over-the-counter doses of ibuprofen, compared with low acetylsalicylic acid, reduce muscle hypertrophy in young individuals after 8 wk resistance training. Because the mechanism behind this effect has not been fully elucidated, we here investigated skeletal molecular responses and myofiber adaptations response to acute chronic training concomitant drug intake. Thirty-one (aged 18-35 yr) healthy men (n = 17) women 14) were randomized receive either...
Aim: The current study aimed to examine the effects of resistance exercise with concomitant consumption high vs. low daily doses non-steroidal anti-inflammatory drugs (NSAIDs) on mitochondrial oxidative phosphorylation in skeletal muscle. As a secondary aim, we compared eccentric overload conventional training. Methods: Twenty participants were randomized either group taking (3 × 400 mg/day) ibuprofen (IBU; 27 ± 5 year; n = 11) or ingesting dose (1 75 acetylsalicylic acid (ASA; 26 4 9)...
For successful growth and maintenance of primary myogenic cells in vitro, culture medium addition sera are the most important factors. At present it is not established as to what extent different origin composition, supplemented media or serum-free conditions influence myoblast function responses stimuli. By assessing markers proliferation, differentiation/fusion, quiescence, apoptosis protein synthesis aim current study was elucidate how human myoblasts myotubes modulated by commonly used...
Nutrient provision after sprint exercise enhances mammalian target of rapamycin (mTOR) signaling. One suggested that nutrient sensor is the class III phosphatidylinositol 3-kinase, vacuolar protein sorting 34 (Vps34), not previously studied in human skeletal muscle. It hypothesized oral ingestion essential amino acids (EAA) and carbohydrates (Carb) increases Vps34 activity mTOR signaling (hVps34) muscle exercise. Nine subjects were performed 3 × 30-sec all-out sprints with or without EAA +...
For chemically enhanced primary treatment (CEPT) with microsieving, a feedback proportional integral controller combined feedforward compensator was used in large pilot scale to control effluent water turbidity desired set points. The from the microsieve maintained at various points range 12-80 NTU basically independent for number of studied variations influent flow rate and wastewater compositions. Effluent highly correlated chemical oxygen demand (COD). Thus, CEPT based on controlling...
The CC-genotype of the VDR polymorphism TaqI rs731236 has previously been associated with a higher risk developing myopathy compared to TT-carriers. However, mechanistic role this in skeletal muscle is not well defined. effects vitamin D on patients genotyped for rs731236, comparing CC and TT-carriers were evaluated. Primary human myoblasts isolated from 4 CC-carriers treated vitro. A dose-dependent inhibitory effect myoblast proliferation differentiation was observed concurrent...
Although nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to modulate skeletal muscle adaptations and protein metabolism in response resistance exercise, little is known about the effects of NSAIDs on mitochondrial function. Thus, current study aimed examine exercise with concomitant NSAID consumption oxidative phosphorylation muscle. Twenty participants were randomized a single-blinded fashion either an experimental group receiving ibuprofen (IBU: 27±5 yr; n=11; 1200 mg/d) or...
Exercise has been found to induce bioactive lipid mediators which possess both pro- and anti-inflammatory activity, yet the role of these in muscle adaptive response resistance exercise (RE) remains be explored. PURPOSE: The present study aimed characterize presence polyunsaturated fatty acid-related lipids human skeletal muscle. Specifically, we hypothesized that high doses drugs (NSAIDs) would hinder action pro-inflammatory pro-resolving acute RE, thereby providing a mechanistic link...
PURPOSE: We recently reported that high doses of non-steroidal anti-inflammatory drugs (NSAIDs) attenuate resistance exercise-induced muscle hypertrophy in young adults. Yet, little is known about the molecular mechanisms behind this effect. The current study aimed to examine acute responses exercise during co- ingestion and low drugs. METHODS: Thirty one (age 18-35 years) healthy men women were randomly assigned daily consumption ibuprofen (IBU; 1200 mg; n=15) or acetylsalicylic acid (ASA;...