A5041538504- Lymphoma Diagnosis and Treatment
- Marine Biology and Ecology Research
- Marine Bivalve and Aquaculture Studies
- Crustacean biology and ecology
- Aquaculture Nutrition and Growth
- Marine and fisheries research
- Cephalopods and Marine Biology
- Neonatal Respiratory Health Research
- Advanced Radiotherapy Techniques
- Plant Physiology and Cultivation Studies
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Food Industry and Aquatic Biology
- Marine Biology and Environmental Chemistry
- Congenital Heart Disease Studies
- Aquatic Invertebrate Ecology and Behavior
- Insect and Arachnid Ecology and Behavior
- Urological Disorders and Treatments
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Coral and Marine Ecosystems Studies
- Genomics and Phylogenetic Studies
- Garlic and Onion Studies
- Bladder and Urothelial Cancer Treatments
Japan Fisheries Research and Education Agency
2013-2025
University of Tokyo Hospital
2023-2025
The University of Tokyo
2024-2025
Toshiba (Japan)
2024
Tokai University
2020-2024
University of Tsukuba
2008-2024
Tokyo Medical and Dental University
2024
Aomori Prefectural Industrial Technology Center
2014-2022
Mie University
2021
Research Institute of Environment, Agriculture and Fisheries, Osaka Prefecture
2021
Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent subtypes non-Hodgkin lymphomas. We used artificial neural networks (multilayer perceptron and radial basis function), machine learning, conventional bioinformatics to predict overall survival molecular DLBCL. The series included 106 cases 730 genes a pancancer immune-oncology panel (nCounter) as predictors. multilayer predicted outcome with high accuracy, an area under curve (AUC) 0.98, ranked all according their importance....
This work studied the effect of spatial and seasonal differences on accumulation functional lipid components in Sargassum horneri (Turner), an edible Japanese seaweed popularly called Akamoku . S. obtained from Samenoura bay area Japan was laboratory cultured to evaluate temperature total lipids (TL), fucoxanthin (Fx) fucosterol (Fs) by alga. The 3 month old were open sea two different geographical locations off Usujiri Matsushima monthly variations, over a year, their TL, Fx Fs contents....
The prognosis of diffuse large B-cell lymphoma (DLBCL) is heterogeneous. Therefore, we aimed to highlight predictive biomarkers. First, artificial intelligence was applied into a discovery series gene expression 414 patients (GSE10846). A dimension reduction algorithm correlate with the overall survival and other clinicopathological variables; included combination Multilayer Perceptron (MLP) Radial Basis Function (RBF) neural networks, gene-set enrichment analysis (GSEA), Cox regression...
Tumor-associated macrophages (TAMs) are associated with a poor prognosis of diffuse large B-cell lymphoma (DLBCL). As heterogeneous, the immune polarization and their pathological role warrant further study. We characterized microenvironment DLBCL by immunohistochemistry in training set 132 cases, which included 10 Epstein-Barr virus-encoded small RNA (EBER)-positive five high-grade lymphomas, gene expression profiling representative subset 37 cases. Diffuse had differential infiltration...
Foodborne disease attributed to the consumption of shellfish contaminated with human norovirus (HuNoV) is one many global health concerns. Our study aimed determine conditions heat-inactivation HuNoV in freshwater clams (Corbicula japonica) using a recently developed cultivation system employing stem-cell derived intestinal enteroids (HIEs). We first measured internal temperature clam tissue water bath during boiling at 90 °C and found that approximately 2 min are required for reach °C....
Abstract Background Opioids are often administered for extremely preterm infants to prevent morbidities (e.g., intraventricular hemorrhage); however, their short-term outcome remains unclear. We aimed assess the association between early-phase opioid use and in-hospital outcomes in infants. Methods This retrospective nationwide cohort study analyzed data from Diagnosis Procedure Combination database Japan. A total of 18,794 hospitalized July 2010 March 2021 were included. The patients...
Abstract Aim This study aims to investigate the association between placental insufficiency and complications in extremely preterm infants context of ischemic disease (IPD), including preeclampsia, small‐for‐gestational‐age (SGA), abruption. Methods Infants born 22 28 weeks gestation were classified into IPD non‐IPD groups, matched 1:1 by gestational age sex. The incidence neonatal was analyzed. Results Analysis included 48 each group. group had a significantly lower birth weight (IPD vs....
Objective To evaluate effectiveness of 60-mW laser irradiation in the treatment tinnitus. Study Design Prospective, randomized double-blind study. Methods This investigation included 68 ears 45 patients with disabling unilateral or bilateral The active placebo was administered transmeatally once a week for 6 minutes. Laser performed four times during 4-week period. A questionnaire to loudness, duration, quality, and annoyance tinnitus before after irradiation. loudness pitch match were...
Objective: We have recently identified using multilayer perceptron analysis (artificial intelligence) a set of 25 genes with prognostic relevance in diffuse large B-cell lymphoma (DLBCL), but the importance this other hematological neoplasia remains unknown. Methods and Results: tested (i.e., ALDOB, ARHGAP19, ARMH3, ATF6B, CACNA1B, DIP2A, EMC9, ENO3, GGA3, KIF23, LPXN, MESD, METTL21A, POLR3H, RAB7A, RPS23, SERPINB8, SFTPC, SNN, SPACA9, SWSAP1, SZRD1, TNFAIP8, WDCP ZSCAN12) series gene...
Tumor-associated macrophages (TAMs) of the immune microenvironment play an important role in Diffuse Large B-cell Lymphoma (DLBCL) pathogenesis. This research aimed to characterize expression macrophage colony-stimulating factor 1 receptor (CSF1R) at gene and protein level correlation with survival. First, immunohistochemical CSF1R was analyzed a series 198 cases from Tokai University Hospital two patterns histological were found, TAMs, diffuse B-lymphocytes pattern. The clinicopathological...
High expression of the anti-apoptotic TNFAIP8 is associated with poor survival patients diffuse large B-cell lymphoma (DLBCL), and one functions to inhibit pro-apoptosis Caspase-8. We aimed analyze immunohistochemical Caspase-8 (active subunit p18; CASP8) in a series 97 cases DLBCL from Tokai University Hospital, correlate other pathway-related markers, including cleaved Caspase-3, PARP, BCL2, TP53, MDM2, MYC, Ki67, E2F1, CDK6, MYB LMO2. After digital image quantification, correlation...
Members of the amphipod suborder Caprellidea exhibit degenerated abdomens and pereopods 3 4. Some genera Podoceridae (Gammaridea, Corophioidea) such as Dulichia also show reduced thus are generally regarded a sister group Caprellidea. In addition, one caprellid families, Caprogammaridae, exhibits abdominal segments that similar to those podocerids, well rudimentary 4, which more consistent with other caprellids. Therefore, an evolutionary scheme has been suggested on basis gradual...
The nucleotide and amino acid sequences the gene order of mitochondrial genome are highly informative for studying phylogeny, population genetics, phylogeography. This study determined complete caprellid species Caprella scaura. C. scaura has a total length 15,079 bp, with an AT content 66.43%. contains typical components, including 13 protein-coding genes, 2 rRNA 22 tRNA genes. In comparison gammarid, some distinct characteristics were found. For example, two conserved blocks is inverted...
Follicular lymphoma (FL) is the second most common in Western countries. FL characterized by being incurable, usually having an indolent clinical course with frequent relapses, and eventual patient’s death or transformation to Diffuse Large B-cell Lymphoma. The immune response tumoral microenvironment, including FOXP3+Tregs, PD-1+TFH cells, TNFRSF14 (HVEM), BTLA play a role pathogenesis. We aimed analyze gene expression of Artificial Intelligence (machine learning, deep learning), identify...
Key Clinical Message Ectopia cordis is a rare condition with expected low survival rate based on past studies. We encountered case of preterm and birth weight infant ectopia cordis. When the cried, prolapse heart, liver, intestinal tract worsened. A pressure‐applying protector was used to protect organs reduce prolapse. Upon application, infant's tachypnea desaturation Fluoroscopic examination suggested that pressure from prolapsed regions impeding pulmonary expansion negatively affecting...
Although patients with chronic pain show behavioral signs of impaired endogenous modulation, responsible cerebral networks have yet to be anatomically delineated. We used diffusion tensor imaging (DTI) examine the white-matter alterations in compared healthy subjects. further measured thermal modulatory responses using offset analgesia (OA) paradigm. tested whether indices associated psychophysical parameters reflecting morbidity and patients, they could serve as diagnostic biomarkers pain.
Follicular lymphoma (FL) is one of the most frequent subtypes non-Hodgkin lymphomas. This research predicted prognosis 184 untreated follicular patients (LLMPP GSE16131 series), using gene expression data and artificial intelligence (AI) neural networks. A new strategy based on random number generation was used to create 120 different independent multilayer perceptron (MLP) solutions, 22,215 probes were ranked according their averaged normalized importance for predicting overall survival....