A5091865646- Blood Coagulation and Thrombosis Mechanisms
- Folate and B Vitamins Research
- Pregnancy and preeclampsia studies
- Peripheral Neuropathies and Disorders
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Atrial Fibrillation Management and Outcomes
- Tryptophan and brain disorders
- Esophageal and GI Pathology
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Autoimmune Neurological Disorders and Treatments
- Iron Metabolism and Disorders
- Immunotherapy and Immune Responses
- Sarcoidosis and Beryllium Toxicity Research
- Renin-Angiotensin System Studies
- Myasthenia Gravis and Thymoma
- GDF15 and Related Biomarkers
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Central Venous Catheters and Hemodialysis
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
Military Hospital of Tunis
2010-2024
Hôpital Militaire Moulay Ismail
2011-2020
Institut des Hautes Études de Tunis
2013-2014
MRC Laboratory of Molecular Biology
2010-2013
Military Hospital
2010
Our aim in this study was to investigate the association between elevated homocysteine levels and two MTHFR polymorphisms, C677T A1298C, with several pregnancy complications such as recurrent loss, preeclampsia, placental abruption intrauterine growth retardation. In 203 women different vasculopathies, we determined A1298C prevalence their relative levels. The mean plasma level significantly higher pathologic groups when compared control group. We identified carriage of polymorphism a...
Background: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role insertion/deletion (I/D) polymorphisms angiotensin-converting enzyme (ACE) gene in etiology CAD remains to be more completely clarified. aim this study was determine ACE I/D polymorphism patients with association together traditional risk factors assessing CAD. Methods: Our population included 145 Tunisian symptomatic control...
We describe the case of a patient with confirmed limbic encephalitis associated leucine-rich glioma-inactivated 1 (LGI1) antibodies. A 59-year-old man presented to Department Neurology bizarre behavior, memory loss, cognitive impairment, visual hallucinations, and myoclonus facio-brachial dystonic seizures. brain magnetic resonance imaging (MRI) revealed no hippocampal lesions. Blood tests showed hyponatremia. An electroencephalogram disorganization slowing background activity. Antiepileptic...
Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between most autoimmune diseases. To our knowledge, simultaneous syndromes of Graves' disease (GD) type 2 diabetes (T2D) are rare Tunisia.We report case 42-year-old woman admitted to department psychiatry for an acute relapse chronic schizophrenia. Her medical history revealed that she was followed mellitus. A low-resolution...
The angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D or indel) polymorphism has long been linked to Alzheimer's disease (AD), but the interpretation of established data remains controversial. aim this study was determine whether is associated with risk in Tunisian patients.We analyzed genotype and allele frequency distribution ACE I/D 60 AD patients 120 healthy controls.There a significantly increased carriers D/D (51.67% vs. 31.67% controls; p = .008, OR 2.32). D also more...
Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among Tunisian population.This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent loss, intra-uterine growth retardation, pre-eclampsia placental abruption. Each subgroup was matched 100 controls analyzed separately. All patients evaluated factor V Leiden, II G20210A mutations group. Protein S, protein C antithrombin levels...
Coronary artery disease (CAD) is one of the chief causes death in world. Several hypotheses have been promoted as for origin disease, among which are genetic predispositions and/or environmental factors. The aim this study was to determine effect factor V (FV) gene polymorphisms (Leiden, G1691A [FVL] and HR2 A4070G) analyze their association with traditional risk factors assessing CAD. Our population included 200 Tunisian patients symptomatic CAD a control group 300 participants matched age...
The hypothesis that human leukocyte antigens (HLAs) confer susceptibility to schizophrenic disorders has been tested by studying linkage and association in family samples. Our goal was evaluate the role of HLA risk developing schizophrenia a Tunisian population.Blood samples for this case-control study were collected from patients Department Psychiatry at Military Hospital Tunisia between July 2012 May 2013.A total 140 with recruited genetic analysis. Controls included 100 persons matched...
Abstract The cause of thrombosis in hemodialysis vascular access is considered to be a multifactorial nature, including stenosis the venous or arterial connection. Therefore, identification relevant thrombotic risk factors could lead an improved antithrombotic therapy. This case control study was performed evaluate relationship between Factor V (G1691A and A4070G) II polymorphisms patients. One hundred twenty‐one patients undergoing dialysis were selected as subjects. sample divided into two...
Vascular access thrombosis represents a serious and common problem in hemodialysis patients. Therefore, identification of relevant thrombotic risk factors could lead to an improved antithrombotic therapy. This case control study was performed evaluate the relationship between some thrombophilias vascular Seventy-eight patients undergoing dialysis (between May 2007 September 2009) were selected as subjects. sample divided into two groups; group 28 who had sustained one or more events that...
Cerebral venous thrombosis (CVT) is a rare complication during pregnancy or the puerperium. Our aim was to identify thrombotic risk profiles that predispose maternal CVT.The study comprised 151 individuals. All participants had workup included following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T A1298C polymorphisms; protein assays: C, S antithrombin; other tests: blood typing screening for...