A5048315541- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- Enhanced Recovery After Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Hip and Femur Fractures
- Neuroendocrine Tumor Research Advances
- Frailty in Older Adults
- Hernia repair and management
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Stoma care and complications
Università Cattolica del Sacro Cuore
2013-2025
Agostino Gemelli University Polyclinic
1996-2025
Ospedale Cristo Re
2013-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2025
Società Italiana di Cardiologia
2021
University of the Sacred Heart
2009-2014
Novartis (United States)
2013
Novartis (Switzerland)
2013
Novartis (Italy)
2010-2012
Newron Pharmaceuticals (Italy)
2010-2011
To prospectively differentiate, at magnetic resonance (MR) imaging, patients with locally advanced nonmucinous rectal cancer who will respond to long-course chemotherapy and radiation therapy (CRT) from those not respond, histopathologic results as the reference standard.Institutional review board approval for this study was obtained, all provided written informed consent. High-spatial-resolution T2-weighted MR images were acquired before 6-8 weeks after CRT in 53 (33 men, 20 women; mean...
In recent years, preoperative therapy has become standard procedure for locally advanced rectal cancer. Tumor shrinkage due to chemotherapy-radiation (CRT) is now a reality, and pathologically complete responses are not uncommon. Some researchers addressing organ preservation, thus increasing the demand both functional morphologic radiologic evaluation of response CRT distinguish responding from nonresponding tumors. On magnetic resonance (MR) images, post-CRT tumor features volume changes...
Although rectal cancer is predominantly a disease of older patients, current guidelines do not incorporate optimal treatment recommendations for the elderly and address only partially associated specific challenges encountered in this population. This results wide variation disparity delivering standard care to subset patients. As burden population continues increase, it crucial assess whether on strategies general can be adopted adults, with same beneficial oncological functional outcomes....
Abstract Liquid biopsy has become a useful alternative in metastatic colorectal cancer (mCRC) patients when tissue of sites is not feasible. In this study we aimed to investigate the clinical utility circulating exosomes DNA management mCRC patients. Exosomes level and KRAS mutational status exosomal was assesed 70 29 CRC primary tumor were analysed at different disease steps evaluating serial blood samples (240 samples). There significant correlation between extension resection localized...
Abstract Background Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality in locally advanced rectal cancer (LARC). Since response to radiotherapy (RT) dose dependent cancer, escalation may lead higher complete rates. The possibility predict patients who will achieve (CR) fundamental. Recently, an early tumour regression index (ERI) was introduced pathological CR (pCR) after nCRT LARC patients. primary endpoints be increase of rate and evaluation feasibility delta...
Abstract Background Laparoscopic lavage was proposed in the 1990s to treat purulent peritonitis patients with perforated acute diverticulitis. Prospective randomized trials had mixed results. The aim of this study determine success rate laparoscopic sepsis control and identify a group that could potentially benefit from treatment. Methods This retrospective multicentre international included consecutive 24 centres who underwent 2005 2015. Results A total 404 were included, 231 whom Hinchey...
Abstract Purpose The incidence of inguinal hernia is higher in elderly because aging-related diseases like prostatism, bronchitis, collagen laxity. A conservative management common to reduce surgery-related risks, however watchful waiting can expose obstruction and strangulation. aim the present study was assess impact emergency surgery a large series with complicated groin identify independent risk factors for postoperative morbidity mortality. predictive performance prognostic scores has...
The aim of this study was to evaluate the prevalence cryoglobulins in patients with chronic hepatitis B and C virus infection investigate association type II III mixed cryoglobulinaemia systemic manifestations liver disease stage outcome (HCV)‐positive patients. We analysed a cohort compared involvement HCV‐positive or cryoglobulinaemia. serum significantly higher than surface antigen (HBsAg)‐positive (55.4 vs 20.6%). In patients, correlated Patients showed risk cirrhosis extrahepatic while...
The clinical, laboratory, and pathologic data of 361 patients who had curative resections for colorectal cancers were collected analyzed in a multiple stepwise regression model. In univariate analysis, among clinical factors, bowel obstruction emergency surgery showed the most significant prognostic value (P = 0.002, P 0.004, respectively). Vegetating growth, Astler-Coller stage tumor, intramural spread, lymph node involvement, synchronous liver metastases resulted variable significantly...
MF59-adjuvanted trivalent influenza vaccine (Novartis Vaccines and Diagnostics, Siena, Italy) has been shown to be more effective than nonadjuvanted in the elderly population. Here we present results from a large-scale, observational, noninterventional, prospective postlicensure study that evaluated safety of subjects aged 65 years or more. The was performed 5 northern Italian health districts during 2006–2007, 2007–2008, 2008–2009 seasons. choice vaccine—either adjuvanted vaccine—was...
The statements produced by the Chairmen and Speakers of 3rd International Symposium on Diverticular Disease, held in Madrid April 11th-13th 2019, are reported. Topics such as current evolving concepts pathogenesis, course disease, news diagnosing, hot topics medical surgical treatments, finally, critical issues disease were reviewed who proposed 39 graded according to level evidence strength recommendation. Each topic was explored focusing more relevant clinical questions. vote conducted a...
Abstract Background After the failure of conservative therapy, most effective surgical treatment for chronic anal fissures (CAFs) is lateral internal sphincterotomy. However, choice procedure must be always evaluated carefully due to risk long-term continence impairment. The aim present study report outcomes fissurectomy with or without associated anoplasty. Methods This a single-center retrospective including patients CAFs in whom medical and non-medical treatments failed who underwent...
Objective: Cardiac hypertrophy due to pressure overload is associated with several cellular electrophysiological alterations such as prolongation of action potential duration (APD), decrease in transient outward current (Ito) and occurrence the pacemaker If. These may play a role sudden arrhythmic death, which major risk factor myocardial failure. Since angiotensin II key signal for myocyte hypertrophy, we tested if an 8-week treatment old spontaneously hypertensive rats (SHR) antagonist...
Surgical resection offers the only potential cure for pancreatic carcinoma. Several recent series have reported an encouraging increase in 5-year survival rate exceeding 20% and emphasized importance of patient selection based on reproducible prognostic factors. The impact demographic, intraoperative, histopatologic factors are investigated this study.Seventy-three patients with adenocarcinoma pancreas, treated at Department Surgery Catholic University Rome during 1988-1998, were...
Diagnostic delay in a group of 189 women with breast cancer was studied and correlated first symptom, stage disease, histologic grade prognosis. divided into patient (time from the patient's discovery symptom to medical consultation) system diagnosis treatment). Patients were five groups by patient-delay time: 0 30 days; 31 90 91 180 181 365 greater than days. The median diagnostic 60 days (range, 4-980) not influenced age, marital status or nature symptom. A consistent direct relationship...
It has been hypothesized that inflammatory response triggered by surgery might induce the release of molecules could promote proliferation, invasion and metastasis surviving cancer cells. To test this hypothesis, levels multiple inflammation-related circulating factors were analyzed in patients undergoing for colorectal cancer. A Luminex xMAP system was used to simultaneously assess IL-1β, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-15, IL-17, FGF, eotaxin,...