A5011111786- Advanced Radiotherapy Techniques
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Management of metastatic bone disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Cancer Genomics and Diagnostics
- Pain Management and Opioid Use
- Endometrial and Cervical Cancer Treatments
University of Chieti-Pescara
2006-2024
Ospedale SS. Annunziata
2017-2024
Vanda Institute
2020
Ospedale Sacro Cuore Don Calabria
2018
University of Perugia
2017
ATS Sardegna (Italy)
2014-2016
Regione Puglia
2016
University Hospital of Basel
2016
Mother Teresa Hospital
2016
Mount Vernon Cancer Centre
2016
BackgroundTo retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset locally advanced rectal cancer (LARC) patients.MethodsA multicentre retrospective cohort study LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different intervals CRT. The 1st group included 300 who underwent...
An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists radiotherapy treatment of pancreatic cancer. A contouring dummy-run two cases cancer treated by postoperative and preoperative (RT) was performed. Clinical history, diagnostics, planning CT imaging were available on AIRO website ( http://www.radioterapiaitalia.it ). Participants requested delineate...
Patients (pts) affected with locally advanced rectal cancer (LARC) may respond differently to neoadjuvant chemoradiotherapy (nCRT). The identification of reliable biomarkers able predict oncological outcomes could help in the development risk-adapted treatment strategies. It has been suggested that inflammation parameters have a role predicting tumor response nCRT and survival cancer, but no definitive conclusion can be drawn at present. aim current study is evaluate baseline inflammatory...
Abstract Background Radiotherapy (RT) is widely used in the treatment of pancreatic cancer. Currently, recommendation has been given for delineation clinical target volume (CTV) adjuvant RT. Based on recently reviewed pathologic data, aim this study to propose criteria CTV definition and including elective nodal irradiation (ENI) preoperative definitive Methods The anatomical structures interest, as well abdominal vasculature were identified intravenous contrast-enhanced CT scans two...
Abstract We recently demonstrated the activation of phosphatidylinositol 3‐kinase (PI3‐K/Akt) survival pathway in Jurkat T leukemia cells known for their sensitivity to tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL)/Apo2L cytotoxic action. The present investigation was done elucidate role cAMP‐response element‐binding (CREB) protein this system. were treated with 100–1,000 ng/ml TRAIL time intervals up 24 h presence or absence selective pharmacologic inhibitors...
The aim of this report was to investigate the feasibility in terms treatment time prolongation an on-line no-action level correction protocol, based on daily electronic portal image verification.The occupation a linear accelerator (LINAC) delivering 3-D conformal treatments monitored for two weeks (from Monday Friday, 10 working days). An device I-View (Elekta, UK) used setup verification. Single-exposure images were acquired using initial 8 monitor units delivered each field. Translational...
Background. An intensified multidrug chemotherapy regimen (raltitrexed plus oxaliplatin, Tom-Ox) concomitant boost radiotherapy, in the neoadjuvant treatment of locally advanced rectal cancer patients, was shown feasible our previous study. The aim this study to evaluate efficacy terms pathologic complete response pre-operative therapy. Material and methods: A Phase II designed clinical stage T3-T4 and/ or N ≥ 1 patients were treated with radiotherapy (55 Gy/5 weeks) concurrent (Tom-Ox)....
The aim of this report was to investigate the feasibility in terms treatment time prolongation an on-line no-action level correction protocol, based on daily electronic portal image verification.The occupation a linear accelerator (LINAC) delivering 3-D conformal treatments monitored for two weeks (from Monday Friday, 10 working days). An device I-View (Elekta, UK) used setup verification. Single-exposure images were acquired using initial 8 monitor units delivered each field. Translational...
Among the molecular events underlying erythroid differentiation, we analyzed signalling pathway leading to cAMP response element binding (CREB) nuclear transcription factor activation. Normal donor blood light density cells differentiated pro-erythroblasts during proliferative phase (10 days) of Human Erithroblast Massive Amplification (HEMA) culture, and orthochromatic erythroblasts, differentiative (4 additional culture. Since erythropoietin was present all over also left in medium for 14...
Abstract Purpose Radical resection (R0) represents the best curative treatment for local recurrence (LR) rectal cancer. Re-irradiation (re-RT) can increase rate of R0 resection. Currently, there is a lack guidelines on Re-RT LR The Italian Association Radiation and clinical oncology gastrointestinal tumors (AIRO-GI) study group released national survey to investigate current practice external beam radiation therapy in these patients. Material methods In February 2021, was designed...
K562 are human erythroleukemia cells inducible to differentiate into megakaryocytic or erythroid lineage by different agents. Cyclic nucleotide Response Element Binding (CREB) protein, a nuclear transcription factor which mediates c-AMP signaling, is potential candidate involved in the occurrence of differentiation and adaptive response. Here we investigated signaling events induced with 30 microM hemin undergo differentiation. CREB activation was detected early 1 h after treatment up 4 6...