A5072899843- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Nuclear Structure and Function
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Protein Kinase Regulation and GTPase Signaling
- Platelet Disorders and Treatments
- Carcinogens and Genotoxicity Assessment
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Pancreatic function and diabetes
- Salivary Gland Tumors Diagnosis and Treatment
- Redox biology and oxidative stress
- Sphingolipid Metabolism and Signaling
- Enzyme Structure and Function
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Urological Disorders and Treatments
- Lysosomal Storage Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Myasthenia Gravis and Thymoma
- Chronic Lymphocytic Leukemia Research
- Genomics and Chromatin Dynamics
CHI Health Creighton University Medical Center - Bergan Mercy
2024-2025
CHI Health
2024-2025
Creighton University
2023-2025
Macquarie University
2024
University of Chieti-Pescara
1989-2017
Sapienza University of Rome
2000
University of Trieste
1993
Research Institute of Human Morphology
1992
University of Bologna
1990-1991
<ns4:p>Background The opioid crisis is a public health challenge in the United States, significantly impacting mortality rates. This has been further exacerbated by COVID-19, contributing to surge substance use and overdose deaths. Methods Data from CDC Wonder Database was used identify use-related deaths States 1999 2023. Crude age-adjusted rates (AAMR) were calculated across different geographic demographic groups. Temporal trends analyzed using Joinpoint Regression Program. Annual...
<ns3:p>A 56-year-old female with a medical history of unspecified hyperthyroidism and recent thyroid storm presented to the ED tachycardia, hypertension, bilateral enlarged parotid glands. During previous hospitalization, she was diagnosed started on methimazole. laboratory findings suggested Graves’ disease an acute storm. The patient also complained glands bilaterally. CT tomography neck revealed no calculi but showed extensive fatty replacement, possibly related methimazole use. Treatment...
Myelofibrosis (MF) is characterized by hyperactivation of thrombopoietin (TPO) signaling, which induces a RPS14 deficiency that de-regulates GATA1 in megakaryocytes hampering its mRNA translation. As mice carrying the hypomorphic Gata1low mutation, reduces levels Gata1 megakaryocytes, develop MF, we investigated whether TPO axis hyperactive this model. contained two times more Tpo liver and plasma than wild-type littermates. Furthermore, LSKs expressed Mpl (five greater normal) protein (two...
The effect of human recombinant DNA interferon-alpha type A on inositol lipid and diacylglycerol metabolism was investigated in Daudi lymphoma whole cells isolated nuclei. In nuclei after 90 min interferon treatment an enhanced rate PIP2 phosphorylation increase DAG mass were observed. cells, 1 treatment, there a rapid transient shift apparently not related to modifications, thus indicating the presence nuclear cytoplasmic compartments fractions with different metabolic features response...
Among the molecular events underlying erythroid differentiation, we analyzed signalling pathway leading to cAMP response element binding (CREB) nuclear transcription factor activation. Normal donor blood light density cells differentiated pro-erythroblasts during proliferative phase (10 days) of Human Erithroblast Massive Amplification (HEMA) culture, and orthochromatic erythroblasts, differentiative (4 additional culture. Since erythropoietin was present all over also left in medium for 14...
Peroxiredoxins (Prx) comprise an extended family of small antioxidant proteins which conserve a thioredoxin-dependent catalytic function that can contribute to cell protection from reactive oxygen species (ROS). ROS generation is one the deleterious intracellular effects ionizing radiation, but role Prx during radiation treatment has not been extensively explored. Present experiments measure on expression human types I (PAGA), II (NKEF-B) and IV (AOE372) in myeloid leukemia cells (K562)....
Ionizing radiation induces a series of multiple intracellular events which can lead to activation caspases, cytoplasmic proteases involved in the occurrence apoptosis. The response leukemic cells ionizing is amplified when they have been pre-treated with anticancer drug etoposide, therefore aim this work has establish lowest etoposide concentration combined dose obtain best antineoplastic response. Two cell lines, HL-60 and Jurkat, employed study, demonstrated different sensitivities...
<ns3:p>A 56-year-old female with a medical history of unspecified hyperthyroidism and recent thyroid storm presented to the ED tachycardia, hypertension, bilateral enlarged parotid glands. During previous hospitalization, she was diagnosed started on methimazole. laboratory findings suggested Graves’ disease an acute storm. The patient also complained glands bilaterally. CT tomography neck revealed no calculi but showed extensive fatty replacement, possibly related methimazole use. Treatment...
Abstract Friend erythroleukemia cells require high doses (15 Gy) of ionizing radiation to display a reduced rate proliferation and an increased number dead cells. Since can activate several signaling pathways at the plasma membrane which lead nuclear translocation proteins, we looked intranuclear system activated by Protein Kinases C, being this family enzymes involved in regulation cell growth death. Our results show early dose‐dependent activity ζ ε isoforms, although PKC is only isoform...
Therapeutic hypothermia (TH) is the only currently approved treatment for neonatal hypoxic-ischemic encephalopathy (HIE) and must be started within 6 hours to optimize effectiveness. This narrow therapeutic window often requires initiation of TH before or during transport. The goal this study was assess effects servo-controlled versus passive transport on short-term outcomes in newborns with HIE. a single-center retrospective case–control neonates HIE treated active Primary included brain...