Yu‐Hung Chen
A5045353995- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Astrophysical Phenomena and Observations
- Cosmology and Gravitation Theories
- Geophysics and Gravity Measurements
- Astrophysics and Cosmic Phenomena
- Microfluidic and Bio-sensing Technologies
- Geophysics and Sensor Technology
- High-pressure geophysics and materials
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Frequency and Time Standards
- DNA Repair Mechanisms
- Atomic and Subatomic Physics Research
- Quantum Dots Synthesis And Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Photocatalysis Techniques
- Black Holes and Theoretical Physics
- Gas Sensing Nanomaterials and Sensors
- Perovskite Materials and Applications
- Statistical and numerical algorithms
- Radio Astronomy Observations and Technology
- Bacterial Identification and Susceptibility Testing
- Nanopore and Nanochannel Transport Studies
- SARS-CoV-2 and COVID-19 Research
- Mechanical and Optical Resonators
National Cheng Kung University
2015-2024
National Tsing Hua University
2023-2024
Massachusetts Institute of Technology
2022-2024
The University of Texas at Austin
2024
Chang Gung University
2024
California Institute of Technology
2014-2023
Chi Mei Medical Center
2018-2023
National Taiwan University Hospital
2022
University of Chicago
2016-2021
Far Eastern Memorial Hospital
2021
The second-generation of gravitational-wave detectors are just starting operation, and have already yielding their first detections. Research is now concentrated on how to maximize the scientific potential astronomy. To support this effort, we present here design targets for a new generation detectors, which will be capable observing compact binary sources with high signal-to-noise ratio throughout Universe.
We present the first analytical inspiral-merger-ringdown gravitational waveforms from binary black holes (BBHs) with nonprecessing spins, that is based on a description of late-inspiral, merger and ringdown in full general relativity. By matching post-Newtonian inspiral to set numerical-relativity simulations, we obtain waveform family conveniently small number physical parameters. These will allow us detect larger parameter space BBH coalescence, including considerable fraction precessing...
Methotrexate (MTX), a stoichiometric inhibitor of dihydrofolate reductase, is chemotherapeutic agent for treating variety neoplasms. Impairment drug import into cells and increase in export from may render resistant to MTX. MTX, when locally administered soluble form, rapidly absorbed through capillaries the circulatory system, which also account therapeutic failure patients. To retain MTX within tumor longer duration alter its pharmacokinetic behavior, we proposed new formulation bound gold...
Abstract We perform a statistical standard siren analysis of GW170817. Our does not utilize knowledge NGC 4993 as the unique host galaxy optical counterpart to Instead, we consider each within GW170817 localization region potential host; combining redshifts from all galaxies with distance estimate provides an Hubble constant, H 0 . Considering brighter than equally likely binary neutron star merger, find km s −1 Mpc (maximum posteriori and 68.3% highest density posterior interval; assuming...
High atomic number material, such as gold, may be used in conjunction with radiation to provide dose enhancement tumors. In the current study, we investigated dose-enhancing effect and apoptotic potential of gold nanoparticles combination single-dose clinical electron beams on B16F10 melanoma tumor-bearing mice. We revealed that accumulation was detected inside culture cells after 18 h incubation, moreover, were shown colocalized endoplasmic reticulum Golgi apparatus cells. Furthermore,...
Abstract Objective Angiogenesis plays a part in the pathogenesis of rheumatoid arthritis (RA), and nanogold inhibits activity an angiogenic factor, vascular endothelial growth factor (VEGF). We therefore investigated whether intraarticular delivery ameliorates collagen‐induced (CIA) rats. Methods Binding 13‐nm to VEGF human RA synovial fluid (SF) its effects on SF–induced cell proliferation migration were assessed. Nanogold was administered intraarticularly rats with CIA before onset...
We introduce a novel cooling technique capable of approaching the quantum ground state kilogram-scale system—an interferometric gravitational wave detector. The detectors Laser Interferometer Gravitational-wave Observatory (LIGO) operate within factor 10 standard limit (SQL), providing displacement sensitivity 10−18 m in 100 Hz band centered on 150 Hz. With new feedback strategy, we dynamically shift resonant frequency 2.7 kg pendulum mode to lie this optimal band, where its effective...
Cathepsins have long been considered as housekeeping molecules. However, specific functions also attributed to each of these lysosomal proteases. Squamous cell carcinoma antigen (SCCA) 1, widely expressed in various uterine cervical cells, is an endogenous cathepsin (cat) L inhibitor. In this study, we investigated whether the cat L-SCCA 1 pathway and autophagy were involved resveratrol (RSV)-induced cytotoxicity cancer cells. RSV induced GFP-LC3 aggregation well increased presence LC3-II...
We have searched for gravitational waves from coalescing low mass compact binary systems with a total between 2M⊙ and 35M⊙ minimum component of 1M⊙ using data the first year fifth science run three LIGO detectors, operating at design sensitivity. Depending on mass, we are sensitive to coalescences as far 150 Mpc Earth. No gravitational-wave signals were observed above expected background. Assuming population objects Gaussian distribution representing neutron star systems, black hole–neutron...
Innate immune response is important for viral clearance during influenza virus infection. Galectin-1, which belongs to S-type lectins, contains a conserved carbohydrate recognition domain that recognizes galactose-containing oligosaccharides. Since the envelope proteins of are highly glycosylated, we studied role galectin-1 in infection vitro and mice. We found was upregulated lungs mice There positive correlation between levels loads acute phase Cells treated with recombinant human...
A new methodology has been developed to synthesize gold–silver alloy nanoparticles by laser irradiation of mixtures consisting gold and silver nanoparticles.
We report on a search for gravitational wave bursts using data from the first science run of Laser Interferometer Gravitational Wave Observatory (LIGO) detectors. Our focuses with durations ranging 4 to 100 ms, and significant power in LIGO sensitivity band 150 3000 Hz. bound rate such detected at less than 1.6 events per day 90% confidence level. This result is interpreted terms detection efficiency ad hoc waveforms (Gaussians sine Gaussians) as function their root-sum-square strain hrss;...
We report on a search for gravitational waves from coalescing compact binaries, of total mass between 2 and $35{M}_{\ensuremath{\bigodot}}$, using LIGO observations November 14, 2006 May 18, 2007. No gravitational-wave signals were detected. upper limits the rate binary coalescence as function mass. The cumulative 90%-confidence neutron stars, black holes hole-neutron star systems are $1.4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$,...
We present a LIGO search for short-duration gravitational waves (GWs) associated with soft gamma ray repeater (SGR) bursts. This is the first sensitive to neutron star f modes, usually considered most efficient GW emitting modes. find no evidence of GWs any SGR burst in sample consisting 27 Dec. 2004 giant flare from 1806-20 and 190 lesser events 1900+14. The unprecedented sensitivity detectors allows us set stringent limits on transient amplitudes published date. upper limit estimates...
The evolutionarily conserved Smc5/6 complex is implicated in recombinational repair, but its function this process has been elusive. Here we report that the budding yeast directly binds to DNA helicase Mph1. Mph1 and activity define a replication-associated recombination subpathway. We show pathway toxic when defective, because mph1 Δ mutations suppress multiple defects mutants of complex, including their sensitivity replication-blocking agents, growth defects, inefficient chromatid...
We present the results obtained from an all-sky search for gravitational-wave (GW) bursts in 64--2000 Hz frequency range data collected by LIGO detectors during first year (November 2005---November 2006) of their fifth science run. The total analyzed live time was 268.6 days. Multiple hierarchical analysis methods were invoked this search. overall sensitivity expressed terms root-sum-square (rss) strain amplitude ${h}_{\mathrm{rss}}$ with various morphologies...
We present the analysis of between 50 and 100 h coincident interferometric strain data used to search for establish an upper limit on a stochastic background gravitational radiation. These come from first LIGO science run, during which all three interferometers were operated over 2-week period spanning August September 2002. The method cross correlating outputs two is analysis. describe in detail practical signal processing issues that arise when working with real data, we observational...