A5073321906- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Biochemical Analysis and Sensing Techniques
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- Biochemical effects in animals
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Traditional Chinese Medicine Analysis
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Pharmacology and Obesity Treatment
- Alcoholism and Thiamine Deficiency
- Pharmacological Receptor Mechanisms and Effects
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Ginseng Biological Effects and Applications
- Cynara cardunculus studies
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
University of Cagliari
2011-2023
Neuroscience Institute
2006-2023
National Research Council
2005-2023
National Academies of Sciences, Engineering, and Medicine
2012-2014
Rockefeller University
2011
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2005-2011
International Institute for Management Development
2009
Novartis (Switzerland)
2009
Novartis Institutes for BioMedical Research
2009
AC Immune (Switzerland)
2008-2009
The similarities between the pharmacological effects of gamma-aminobutyric acid receptor agonist, baclofen, and alcohol-substituting agent, gamma-hydroxybutyric acid, led us to investigate whether baclofen was capable reducing (a) ethanol withdrawal syndrome in ethanol-dependent rats (b) voluntary intake ethanol-preferring rats.In experiment 1, Wistar were rendered physically dependent on by repeated administration intoxicating doses for 6 consecutive days. Baclofen acutely administered...
Aims: The present study investigated the effect of newly synthesized cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties in selectively bred Sardinian alcohol-preferring (sP) rats. Methods Results: In Experiment 1, repeated administration SR147778 (0.3–3 mg/kg twice daily, i.p.) specifically suppressed acquisition drinking behaviour alcohol-naive rats exposed to two-bottle ‘alcohol vs water’ choice regimen for 24 h/day. 2, an acute (2.5–10 mg/kg,...
Background Administration of the GABA B receptor agonist, baclofen, and positive allosteric modulator, GS 39783, has been repeatedly reported to suppress multiple alcohol‐related behaviors, including operant oral alcohol self‐administration, in rats. This study was designed compare effect baclofen 39783 on self‐administration 3 lines selectively bred, alcohol‐preferring rats: Indiana ( P ), S ardinian sP A lko lcohol AA ). Methods Rats each line were initially trained respond a lever, fixed...
Background: Activation of the GABA B receptor—either by means direct agonists (like baclofen) or positive allosteric modulators GS39783)—has been observed to suppress alcohol drinking and reinforcement in rats mice. The present study was conducted assess compare effect baclofen GS39783 on motivational properties alcohol. Methods: Selectively bred Sardinian alcohol‐preferring (sP) were initially trained respond a lever (on an fixed ratio 4 schedule reinforcement) orally self‐administer (15%,...
Pharmacological blockade of the cannabinoid CB1 receptor has been repeatedly reported to suppress intake food, including highly palatable foods, in laboratory animals. This study was designed investigate whether treatment with antagonist, rimonabant, would reduce reinforcing and motivational properties a chocolate-flavoured beverage [containing 5% (w/v) chocolate powder] nonfood-deprived nonwater-deprived Wistar rats trained self-administer this under an operant conditioning procedure. also...
The positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, have been found to reduce alcohol self-administration in alcohol-preferring rats. present study was designed assess effect newly synthesized modulator BHF177, on alcohol's reinforcing motivational properties selectively bred Sardinian (sP) rats.sP rats were initially trained respond a lever [on fixed ratio 4 (FR4) schedule reinforcement] orally self-administer (15%, v/v) or sucrose (1 3%, w/v) daily 30-minute...
Background: This study assessed in Sardinian alcohol‐preferring (sP) rats a procedure known to promote alcohol drinking and based on the intermittent (once every other day) access 2 bottles containing (20%, v/v) water, respectively (Wise, 1973). Methods: To this end, sP were exposed – under 2‐bottle choice regimen to: (i) 10% (v/v) with continuous (CA10%; i.e., which had been selectively bred); (ii) (IA10%); (iii) 20% (CA20%); (iv) (IA20%; “Wise” condition) (Experiment 1). Additional...
Background: Recent animal studies have shown that the level of stress-responsive arginine vasopressin (AVP) gene expression in amygdala is increased during early withdrawal from long-term heroin or cocaine administration. The selective AVP V1b receptor antagonist SSR149415 (capable exerting antidepressant-like and anxiolytic effects models) also blocked stress-induced reinstatement drug-seeking behavior. This study was undertaken to investigate alcohol determine whether (i) there are...
Abstract Two γ‐hydroxybutyric acid (GHB) analogues, trans ‐γ‐hydroxycrotonic (t‐HCA) and γ‐(p‐methoxybenzyl)‐γ‐hydroxybutyric (NCS‐435) displaced [ 3 H]GHB from GHB receptors with the same affinity as but, unlike GHB, failed to displace H]baclofen GABA B receptors. The effect of baclofen, on G protein activity hippocampal extracellular glutamate levels was compared. While baclofen stimulated 5′‐O‐(3‐[ 35 S]thiotriphospate) S]GTPγS binding both in cortex homogenate cortical slices, t‐HCA...