A5072295652- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Body Composition Measurement Techniques
- Dietary Effects on Health
- Mitochondrial Function and Pathology
- Cardiovascular Health and Disease Prevention
- Pancreatitis Pathology and Treatment
- Sphingolipid Metabolism and Signaling
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
Laiko General Hospital of Athens
2009-2025
National and Kapodistrian University of Athens
2017-2025
Heinrich Heine University Düsseldorf
2013-2022
Deutsches Diabetes-Zentrum e.V.
2013-2022
German Center for Diabetes Research
2014-2022
University General Hospital Attikon
2010-2022
Athens Medical Center
2018
Düsseldorf University Hospital
2014
Eugenides Hospital
2009-2013
Athens Naval & Veterans Hospital
2012
Significance Muscle insulin resistance is a major factor in the pathogenesis of type 2 diabetes, but underlying cellular mechanisms are yet unclear. This study found that muscle diacylglycerol content was temporally associated with protein kinase Cθ activation and impairment signaling human skeletal muscle. A similar relationship between observed insulin-resistant obese diabetic individuals. In contrast, we no other putative mediators including ceramides, acylcarnitines, or circulating...
OBJECTIVE Insulin resistance and nonalcoholic fatty liver disease have been linked to several lipid metabolites in animals, but their role humans remains unclear. This study examined the relationship of sphingolipids with hepatic peripheral metabolism 21 insulin-resistant obese patients without (NAFL−) or (NAFL+) steatohepatitis (NASH) 7 healthy lean individuals undergoing tissue biopsies during bariatric elective abdominal surgery. RESEARCH DESIGN AND METHODS Hyperinsulinemic-euglycemic...
Type 2 diabetes mellitus (T2DM) is a progressive multisystemic disease that increases significantly cardiovascular morbidity and mortality. It associated with obesity, insulin resistance, beta-cell dysfunction, hyperglucagonemia, the combination of which typically leads to hyperglycemia. Incretin-based treatment modalities, in particular glucagon-like peptide 1 (GLP-1) receptor agonists, are able successfully counteract several underlying pathophysiological abnormalities T2DM. The pancreatic...
Studies in rodents suggest that insulin controls hepatic glucose metabolism through brain-liver crosstalk, but human studies using intranasal to mimic central delivery have provided conflicting results. In this randomized controlled crossover trial, we investigated the effects of on sensitivity (HIS) and energy 10 patients with type 2 diabetes lean healthy participants (CON). Endogenous production was monitored [6,6-2H2]glucose, hepatocellular lipids (HCLs), ATP, inorganic phosphate...
OBJECTIVE Altered immune reactivity precedes and accompanies type 1 2 diabetes. We hypothesized that the metabolic phenotype relates to systemic cellular status. RESEARCH DESIGN AND METHODS A total of 194 metabolically well-controlled patients with diabetes (n = 62, mean duration 1.29 years) or 132, 1.98 60 normoglycemic persons underwent blood sampling for automated white cell counting (WBC) flow cytometry. Whole-body insulin sensitivity was measured hyperinsulinemic-euglycemic clamp tests....
Abstract The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks metabolic surgery. Initial occurs parallel with a decrease oxidative capacity respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack rapid changes sensitivity....