A5049385952- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Alcohol Consumption and Health Effects
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Health and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Sodium Intake and Health
- Spectroscopy and Chemometric Analyses
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Global Public Health Policies and Epidemiology
- Diabetes Treatment and Management
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Health disparities and outcomes
- Health Literacy and Information Accessibility
Cedars-Sinai Medical Center
2020-2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
Brigham and Women's Hospital
2017-2022
Harvard University
2017-2022
Cedars-Sinai Smidt Heart Institute
2020-2022
Universidade Estadual de Campinas (UNICAMP)
2018
Google (United States)
2017
Framingham Heart Study
2017
Brandeis University
2012
Diverse sets of complete human genomes are required to construct a pangenome reference and understand the extent complex structural variation. Here, we sequence 65 diverse build 130 haplotype-resolved assemblies (130 Mbp median continuity), closing 92% all previous assembly gaps reaching telomere-to-telomere (T2T) status for 39% chromosomes. We highlight continuity loci, including major histocompatibility (MHC), SMN1/SMN2, NBPF8, AMY1/AMY2, fully resolve 1,852 variants (SVs). In addition,...
Objective To determine the role of early onset versus late hypertension as a risk factor for in offspring and cardiovascular death.Design Multigenerational, prospective cohort study.Setting Framingham Heart Study.Participants Two generations community dwelling participants with blood pressure measurements performed at serial examinations spanning six decades: 3614 first generation mortality data 1635 initially non-hypertensive second available on parental pressure.Main outcome measures The...
Parental hypertension is known to predict high blood pressure (BP) in children. However, the extent which risk for conferred across multiple generations, notwithstanding impact of environmental factors, unclear. Our objective was therefore evaluate degree extends generations individuals community.We studied three Framingham Heart Study participants with standardized measurements performed at serial examinations spanning 5 decades (1948 through 2005): First Generation (n = 1809), Second...
We sought to determine the extent of SARS-CoV-2 seroprevalence and factors associated with across a diverse cohort healthcare workers.
Untargeted liquid-chromatography-mass spectrometry (LC-MS)-based metabolomics analysis of human biospecimens has become among the most promising strategies for probing underpinnings health and disease. Analysis spectral data across population scale cohorts, however, is precluded by day-to-day nonlinear signal drifts in LC retention time or batch effects that complicate comparison thousands untargeted peaks. To date, there exists no efficient means visualization quantitative assessment drift,...
The application of metabolomics technology to epidemiological studies is emerging as a new approach elucidate disease etiology and for biomarker discovery. However, analysis data complex there an urgent need the standardization workflow reporting study findings. To inform development such guidelines, we conducted survey 47 cohort representatives from Consortium Metabolomics Studies (COMETS) gain insights into current strategies procedures used analyzing in worldwide. results indicated...
Lancet Public Health 2018;3:e419–e428.DOI 10.1016/S2468-2667(18)30135-XURL: http://www.ncbi.nlm.nih.gov/pubmed/30122560
<h3>Importance</h3> Given that hypertension remains a leading risk factor for chronic disease globally, there are substantial ongoing efforts to define the optimal range of blood pressure (BP). <h3>Objective</h3> To identify common threshold level above which BP rise tends accelerate in progression toward hypertension. <h3>Design, Setting, and Participants</h3> This longitudinal, community-based epidemiological cohort study adults enrolled Framingham, Massachusetts, included 1252...
Emerging technologies now allow for mass spectrometry-based profiling of thousands small molecule metabolites ('metabolomics') in an increasing number biosamples. While offering great promise insight into the pathogenesis human disease, standard approaches have not yet been established statistically analyzing increasingly complex, high-dimensional metabolomics data relation to clinical phenotypes, including disease outcomes. To determine optimal analysis, we formally compare traditional and...
OBJECTIVE To assess the relation of type 2 diabetes occurring earlier (age &lt;55 years) versus later in life to risk cardiovascular death and offspring. RESEARCH DESIGN AND METHODS In Framingham Heart Study, a community-based prospective cohort study, glycemic status was ascertained at serial examinations over six decades among 5,571 first- second-generation participants with mortality data 2,123 who initially did not have on parental status. We assessed cause case (cardiovascular...
Abstract Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce de novo haplotype-resolved assemblies often require either difficult-to-acquire parental data or an intermediate haplotype-collapsed assembly. Here, we present Graphasing, a workflow which synthesizes the global phase signal of Strand-seq with assembly graph topology chromosome-scale haplotypes diploid genomes. Graphasing readily integrates any that both outputs...
To assist with management and interpretation of human metabolomics data, which are rapidly increasing in quantity complexity, we need better visualization tools. Using a dataset several hundred metabolite measures profiled cohort ~1500 individuals sampled from population-based community study, performed association analyses eight demographic clinical traits outcomes. We compared frequently used existing graphical approaches novel ‘rain plot’ approach to display the results these analyses....
ABSTRACT Importance Antibody testing is important for understanding patterns of exposure and potential immunity to SARS-CoV-2. Prior data on seroprevalence have been subject variations in selection individuals nature as well timing relation exposures. Objective We sought determine the extent SARS-CoV-2 seroprevalance factors associated with seroprevelance across a diverse cohort healthcare workers. Design Observational study workers, including serology participant questionaires. Participants...
Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce
ABSTRACT We describe the rationale, design, and implementation of baseline enrollment for a longitudinal, observational cohort study healthcare workers. The importance workplace as characteristic interest in population-based studies has become increasingly apparent over time. Most adults spend majority their waking hours living environment, which serves source unique well shared exposures, stressors, related determinants health. A rapidly expanding segment working population includes those...
Abstract Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators ICB-irAEs remain poorly understood. Using non-targeted mass spectrometry, here we identify bio-active lipid linoleoyl-lysophosphatidylcholine (LPC 18:2) as modulator ICB-irAEs. In three independent human studies ICB treatment for solid tumor, loss LPC 18:2 preceded development severe irAEs across multiple organ...