A5030445067- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Extracellular vesicles in disease
- Ombudsman and Human Rights
- International Business and FDI
- Law, logistics, and international trade
- Judicial and Constitutional Studies
- International Arbitration and Investment Law
- Corporate Finance and Governance
Zhejiang University
2010-2024
Purpose The purpose of this paper is to investigate the role cross-listing in overcoming liability origin (LOO) facing emerging economy corporations (EECs). Design/methodology/approach This takes Chinese firms' Hong Kong and establishment international joint ventures (IJVs) with foreign partners as research setting. an empirical study using Heckman's self-selection model primary econometric technique two-stage least square (2SLS) regressions supplementary estimation procedure. Findings...
Understanding the endogenous mechanism of adaptive response to drug-induced liver injury (arDILI) may discover innovative strategies manage DILI. To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in toosendanin-induced (TILI) mice. Exosomal miR-106b-5p was identified as a specific regulator arDILI by comprehensive miRNA profiling. Outstandingly, agomir treatment alleviated TILI and other DILI inhibiting apoptosis promoting hepatocyte proliferation. Conversely,...
Background: Adaptive responses to drug-induced liver injury (arDILI) are of critical importance in restorative tissue repair. However, the underlying mechanism remain elusive.Methods: To gain mechanistic insight into arDILI, we investigated exosomal miRNAs toosendanin-induced (TILI) mice, which is a typical model arDILI. miR-106b-5p was identified as specific regulator Its target gene validated by reporter and siRNA assays. DILI patient samples were collected confirm clinical significance....
Abstract Background Adaptive response to drug-induced liver injury (arDILI) reflects the critical role of restorative tissue repair, and understanding endogenous mechanism may discover innovative strategies manage DILI. Methods To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in adaptive toosendanin-induced (TILI) mice. Exosomal miR-106b-5p was identified as a specific regulator arDILI by comprehensive miRNA profiling. Its target gene validated dual luciferase...