Carlos A.G. van Mieghem

ORCID: 0000-0003-3622-8771
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About
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Research Areas
  • Coronary Interventions and Diagnostics
  • Cardiac Imaging and Diagnostics
  • Cardiac Valve Diseases and Treatments
  • Acute Myocardial Infarction Research
  • Cerebrovascular and Carotid Artery Diseases
  • Advanced MRI Techniques and Applications
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Advanced X-ray and CT Imaging
  • Peripheral Artery Disease Management
  • Cardiac and Coronary Surgery Techniques
  • Radiation Dose and Imaging
  • Aortic aneurysm repair treatments
  • Cardiac Structural Anomalies and Repair
  • Cardiovascular Disease and Adiposity
  • Coronary Artery Anomalies
  • Atrial Fibrillation Management and Outcomes
  • Obesity and Health Practices
  • Cancer Treatment and Pharmacology
  • Cardiovascular Function and Risk Factors
  • Hemodynamic Monitoring and Therapy
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Dietetics, Nutrition, and Education
  • Cardiac Arrhythmias and Treatments
  • Health Promotion and Cardiovascular Prevention
  • Renal and Vascular Pathologies

AZ Groeninge
2019-2024

Onze Lieve Vrouwziekenhuis Hospital
2012-2018

Maasstad Ziekenhuis
2010-2015

Medical University of Graz
2014

Erasmus University Rotterdam
2004-2012

Erasmus MC
2005-2011

Rotterdam University of Applied Sciences
2007

GGD Rotterdam-Rijnmond
2006

KU Leuven
2003

The diagnostic performance of the latest 64-slice CT scanner, with increased temporal (165 ms) and spatial (0.4 mm3) resolution, to detect significant stenoses in clinically relevant coronary tree is unknown.We studied 52 patients (34 men; mean age, 59.6+/-12.1 years) atypical chest pain, stable or unstable angina pectoris, non-ST-segment elevation myocardial infarction scheduled for conventional angiography. All had sinus rhythm. Patients initial heart rates > =70 bpm received...

10.1161/circulationaha.105.533471 article EN Circulation 2005-10-04

The aim was to validate, update, and extend the Diamond–Forrester model for estimating probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Prospectively collected data from 14 hospitals on patients with chest pain without history CAD referred conventional angiography (CCA) were used. Primary outcome CAD, defined as ≥50% stenosis one or more vessels CCA. validity assessed using calibration plots, calibration-in-the-large, recalibration logistic regression....

10.1093/eurheartj/ehr014 article EN European Heart Journal 2011-03-02

Background— The impact of drug-eluting stent (DES) implantation on the incidence major adverse cardiovascular events in patients undergoing percutaneous intervention for left main (LM) coronary disease is largely unknown. Methods and Results— From April 2001 to December 2003, 181 underwent LM stenosis at our institution. first cohort consisted 86 (19 protected LM) treated with bare metal stents (pre-DES group); second comprised 95 (15 exclusively DES. 2 cohorts were well balanced all...

10.1161/01.cir.0000158486.20865.8b article EN Circulation 2005-03-22

The present analysis addresses the potential clinical and physiologic significance of discordance in severity coronary artery disease between angiogram fractional flow reserve (FFR) a large unselected patient population. Between September 1999 December 2011, FFR percent diameter stenosis (DS) as assessed by quantitative angiography were obtained 2986 patients (n = 4086 stenoses), whom at least one was intermediate angiographic severity. Fractional correlated slightly but significantly with...

10.1093/eurheartj/ehu094 article EN European Heart Journal 2014-03-18

<b>Objectives</b> To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations. <b>Design </b>Retrospective pooled analysis individual patient data. <b>Setting </b>18 hospitals Europe and United States. <b>Participants</b> Patients with stable chest pain without evidence for previous disease, if they were referred computed tomography (CT) based angiography or catheter (indicated as high settings, respectively). <b>Main...

10.1136/bmj.e3485 article EN cc-by-nc BMJ 2012-06-12

Although previous generations of multislice computed tomography (CT) have demonstrated accurate detection obstructive bypass graft disease, progression coronary disease is a more frequent cause for ischaemic symptoms late after surgery. We explored the diagnostic performance 64-slice CT in symptomatic patients surgery, assessment both grafts and native arteries. The angiography (Siemens Sensation 64, Germany) was performed 52 patients, 10 ± 5 years Two independent, blinded observers assessed...

10.1093/eurheartj/ehl155 article EN European Heart Journal 2006-07-17

Fractional flow reserve (FFR) is well established for patients undergoing percutaneous coronary intervention, yet little known about candidates artery bypass graft surgery.From 2006 to 2010, we retrospectively included in this registry 627 consecutive treated by surgery having at least 1 angiographically intermediate stenosis. In 429 patients, was based solely on angiography (angiography-guided group). 198 stenosis grafted with an FFR ≤0.80 or deferred >0.80 (FFR-guided The end point major...

10.1161/circulationaha.113.002740 article EN Circulation 2013-08-29

Background— Surveillance conventional coronary angiography (CCA) is recommended 2 to 6 months after stent-supported left main artery (LMCA) percutaneous intervention due the unpredictable occurrence of in-stent restenosis (ISR), with its attendant risks. Multislice computed tomography (MSCT) a promising technique for noninvasive evaluation. We evaluated diagnostic performance high-resolution MSCT detect ISR stenting LMCA. Methods and Results— Seventy-four patients were prospectively...

10.1161/circulationaha.105.608950 article EN Circulation 2006-08-08

Background— Fractional flow reserve (FFR) measurement of intermediate coronary stenoses is recommended by guidelines when demonstration ischemia noninvasive testing unavailable. The study aims to evaluate the penetration this recommendation into current thinking about revascularization strategies for stable artery disease. Methods and Results— International Survey on Interventional Strategy was conducted via a web-based platform. First, participants’ experiences in interventional cardiology...

10.1161/circinterventions.114.001608 article EN Circulation Cardiovascular Interventions 2014-10-22

This study sought to report the 5-year outcomes of everolimus-eluting stents (EES) and paclitaxel-eluting (PES) in an all-comers population undergoing percutaneous coronary intervention (PCI). The medium-term 1 2-year results prospective randomized COMPARE trial (A Trial Everolimus-Eluting Stents Paclitaxel-Eluting for Coronary Revascularization Daily Practice) showed superior clinical with EES compared PES PCI population. Whether this benefit is sustained over longer-term follow-up unknown....

10.1016/j.jcin.2015.03.028 article EN cc-by-nc-nd КАРДИОЛОГИЯ УЗБЕКИСТАНА 2015-07-22

The aim of this study was to assess prospectively the clinical benefits fractional flow reserve (FFR) in guiding coronary artery bypass grafting (CABG).GRAFFITI is a single-blinded, prospective, multicentre, randomised controlled trial FFR-guided versus angiography-guided CABG. We enrolled patients undergoing angiography, having significantly diseased left anterior descending or main stem and at least one more major with intermediate stenosis, assessed by FFR. Surgical strategy defined based...

10.4244/eij-d-19-00463 article EN EuroIntervention 2019-12-01

Complete revascularization of the culprit and all significant nonculprit lesions in patients with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) multivessel disease (MVD) reduces major adverse cardiac events, but optimal timing remains unclear. This study aims to compare immediate complete (ICR) staged (SCR) presenting NSTE-ACS MVD. prespecified substudy BIOVASC (Percutaneous Revascularization Strategies Using Sirolimus Eluting Biodegradable Polymer Coated Stents Patients...

10.1016/j.jcin.2024.01.278 article EN cc-by КАРДИОЛОГИЯ УЗБЕКИСТАНА 2024-03-01

To assess the potential relation between plaque composition and vascular remodelling by using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data.41 coronary vessels with non-significant (< 50% diameter stenosis angiography), < or = 20 mm, non-ostial lesions located in non-culprit underwent IVUS interrogation. data obtained a 30 MHz catheter, were analysed virtual histology software. A index (RI) was calculated divided into three groups. Lesions RI > 1.05 considered to...

10.1136/hrt.2004.057810 article EN Heart 2005-06-18

There is no mention in the current "appropriateness criteria for CTCA" of need CTCA investigation prior to an attempt at recanalisation a CTO. To define better role treatment patients with CTOs, we performed consecutive cohort eligible who were scheduled percutaneous CTO.Symptomatic due CTO suitable included. One hundred and thirty-nine (142 CTOs) studied. Overall success rate was 62.7%. By CTCA, occlusion length 24.9 +/- 18.3 vs. 30.7 20.7 mm successful failed cases (p = 0.1), but frequency...

10.4244/eijv4i5a102 article EN EuroIntervention 2009-03-01

We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated repeated percutaneous intervention.A total 24 consecutive have undergone intervention to treat post-SES (27 lesions). The was located within in 93% lesions. From 27 lesions, 1 (4%) re-treated a bare stent, 3 (11%) were balloon dilatation, remaining 23 lesions (85%) drug-eluting (SES 12 [44%], paclitaxel-eluting stents 11 [41%]). event-free...

10.1161/01.cir.0000130173.63105.4e article EN Circulation 2004-05-18
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