A5030412620- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Aortic aneurysm repair treatments
- Cancer, Hypoxia, and Metabolism
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Soil Moisture and Remote Sensing
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- High Altitude and Hypoxia
- Cardiac and Coronary Surgery Techniques
- Pluripotent Stem Cells Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Academic Writing and Publishing
- Virus-based gene therapy research
- Congenital heart defects research
- Medical Coding and Health Information
- Chemotherapy-induced cardiotoxicity and mitigation
- Clinical practice guidelines implementation
- COVID-19 Clinical Research Studies
Inagro (Belgium)
2023
Antwerp University Hospital
2011-2019
University of Antwerp
2010-2019
Erasmus University Rotterdam
2015-2017
Erasmus MC
2015-2017
Ziekenhuisnetwerk Antwerpen Stuivenberg
2014
Complete revascularization of the culprit and all significant nonculprit lesions in patients with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) multivessel disease (MVD) reduces major adverse cardiac events, but optimal timing remains unclear. This study aims to compare immediate complete (ICR) staged (SCR) presenting NSTE-ACS MVD. prespecified substudy BIOVASC (Percutaneous Revascularization Strategies Using Sirolimus Eluting Biodegradable Polymer Coated Stents Patients...
Background Quantitative real-time PCR (qPCR) is a widely used technique for gene expression analysis. Its reliability highly dependent upon selection of the appropriate reference genes accurate normalization. In this study, we investigated stability 10 commonly in mouse myocardial infarction model. Methods & Results The (Actb, B2m, Eef1a1, Gapdh, Hprt, Polr2a, Ppia, Rpl13a, Tbp, Tpt1) was analyzed using geNorm software. Overall, combination Rpl13a and Tpt1 most stable set our experiments....
The present report describes a novel coronary fractional flow reserve (FFR) system which allows FFR assessment using rapid exchange microcatheter (RXi).The RXi is compatible with standard 0.014" guidewires facilitating lesion negotiation and in wide range of anatomies. In case serial lesions, would have the important advantage allowing multiple pullbacks while maintaining wire access to vessel. fibre-optic sensor technology-based device. This technology might allow reduction signal drift....
Percutaneous coronary interventions (PCI) have become a reliable revascularisation option to treat ischaemic artery disease. Drug-eluting stents (DES) are widely used as first choice devices in many procedures due their established good medium long term outcomes. These permanent implants, however, do not any residual function after vascular healing following the PCI. Beyond this initial period, metallic may induce new problems, resulting an average rate of 2 % reinterventions per year. To...
Despite positive reports on the efficacy of stem cell therapy for treatment cardiovascular disease, nature homing to ischemic tissues remains elusive. We used a mouse model peripheral tissue ischemia study survival and capacity dual reporter gene (eGFP/Luciferase) expressing bone marrow-derived stromal cells (BMSC). Cell were studied in presence absence ciclosporin A (CsA) immunosuppression using bioluminescence imaging (BLI) together with confocal endomicroscopy. Different injection...
Models of experimental ischemia-reperfusion (IR) in adiponectin knockout animals have shown that mediates protection against the development IR injury. However, role injury humans is largely unknown. In a total 234 ST segment elevation myocardial infarction (STEMI) patients, baseline circulating concentration was correlated with after primary percutaneous coronary intervention (pPCI) and major adverse cardiac events (MACE, death hospitalization) during one year follow up. defined by serial...
Drug-eluting stents (DES) are widely used as first choice devices in percutaneous coronary interventions. However, certain concerns associated with the use of DES, i.e. delayed arterial healing a subsequent risk neo-atherosclerosis, late stent thrombosis and hypersensitivity reactions to DES polymer. Bioresorbable vascular scaffolds next step interventions introducing concept supporting natural process following initial intervention without leaving any foreign body materials resulting...
Today the modern world is facing an unprecedented health crisis. The COVID-19 pandemic putting extensive strain on healthcare systems hospitals and medical workers worldwide. Epidemiological data are emerging that patients with cardiac risk factors or pre-existing conditions at increased for complications mortality from COVID-19. As we just begin to understand pathophysiology underlying disease involvement of heart whether through direct myocardial infection damage due already evident. Also...
ObjectivesTo investigate one-year outcomes after implantation of a bioresorbable vascular scaffold (BVS) in patients presenting with acute coronary syndrome (ACS) compared to stable angina patients.BackgroundRobust data on the outcome BVS setting ACS is still scarce.MethodsTwo investigator initiated, single-center, single-arm registries have been pooled for purpose this study, namely Expand and STEMI registries.ResultsFrom September 2012–October 2014, 351 total 428 lesions were enrolled. 255...
To eliminate some of the potential late limitations permanent metallic stents, bioresorbable coronary stents or 'bioresorbable vascular scaffolds' (BVS) have been developed. We reviewed all currently available clinical data on BVS implantation. Since 2015 position statement appropriateness in percutaneous interventions, several large randomised trials presented. These demonstrated that achieving adequate 1 and 2 year outcomes with these first-generation is not straightforward. first...
Currently, the use of bioresorbable vascular scaffolds (BRS) for treatment left main (LM) coronary artery disease has to be considered investigational.However, some early evidence from case reports supports feasibility BRS implantation in selected cases and shows good angiographic clinical results with current-generation devices.However, before routine LM can advocated, more data on long-term safety efficacy larger scaffold designs are essential.
Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function CAC. Data from publicly available gene expression data sets were used to analyse transcriptome in vitro cultured CAC (CACiv). Genes pathways interest further evaluated using qPCR comparing CACiv versus CD14+ monocytic cells. The strongly related tissue macrophages, more specifically regulatory M2c macrophages....
Polders are areas reclaimed on the sea thanks to hydraulic structures like dikes. To prevent flooding, these low-lying constantly drained by a network of ditches that release excess water in (e.g. at low tide). The use subsurface drainage pipes connected existing further enabled lands and made them suitable for agriculture. While groundwater remains saline from its seaborn nature, with years precipitation, fresh lens, lighter than deeper water, developed near soil surface, top water. This...
Polders are low-lying areas that constantly drained by a network of ditches and subsurface drains.While the groundwater remains saline water from its seaborn nature, precipitation effective recharge over years, created freshwater lens on top water.This is essential for most conventional crops.However, intensive rainfall events prolonged summer droughts becoming more frequent with Climate Change lead to decreasing thickness, endangering crop yield.Controlled drainage systems enable regulating...
Aim . We investigated the effects of adiponectin deficiency on circulating angiogenic cell (CAC) mobilization, homing, and neovascularization in setting acute myocardial infarction (AMI). Methods & Results AMI was induced wild-type (WT) (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>10</mml:mn></mml:math>) knockout ( Adipoq −/− ) mice id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>7</mml:mn></mml:math>). One week after...