A5016144181- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- COVID-19 epidemiological studies
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- HIV/AIDS oral health manifestations
- Dengue and Mosquito Control Research
- HIV Research and Treatment
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Salmonella and Campylobacter epidemiology
- Vector-borne infectious diseases
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
Ministry of Health and Population
2021-2025
Department of Health Services
2024-2025
Sukraraj Tropical & Infectious Disease Hospital
2014-2024
Government of Nepal
2021-2024
Tribhuvan University
2021
A complete genome sequence was obtained for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from an oropharyngeal swab specimen of Nepalese patient with disease 2019 (COVID-19), who had returned to Nepal after traveling Wuhan, China.
Abstract Background Dengue is one of the newest emerging diseases in Nepal with increasing burden and geographic spread over years. The main objective this study was to explore epidemiological patterns dengue since its first outbreak (2006) 2019 Nepal. Methods This a retrospective analysis that covers last 14 years (2006–2019) reported cases from Epidemiology Diseases Control Division (EDCD), Ministry Health Population, Government . Reported were plotted time maps case incidence generated...
Background: Nepal piloted a multipronged supervision, performance assessment, and recognition strategy (SPARS), to improve medicines management (MM) in public health facilities. This paper describes the SPARS pilot intervention reports on MM at baseline.
Abstract Background Dengue cases have been continuously reported in Nepal, including some large outbreaks, since its first introduction 2004. The disease is now expanding towards newer locations above 1400 m high, especially the country's capital city, Kathmandu. In 2019, >14,000 dengue six deaths were reported. This study was aimed at detection and molecular characterization of virus (DENV) patients. Methods A total 451 patients enrolled this study. Demographic, clinical laboratory...
Enteric fever, a systemic infection caused by
The increasing incidence of methicillin-resistant and biofilm-forming S. aureus isolates in hospital settings is a gruesome concern today. main objectives this study were to determine the burden clinical samples, assess their antibiotic susceptibility pattern detect biofilm formation mecA gene them. A total 1968 different specimens processed isolate following standard microbiological procedures. Antibiotic test was performed by Kirby-Bauer disc-diffusion method CLSI guidelines. Biofilm...
Background Nepal's Ministry of Health and Population piloted the Supervision, Performance Assessment, Recognition Strategy (SPARS), a multipronged strategy to improve medicines management practices in health facilities. Medicines supervisors (MMS) periodically assess facility performance using 25 indicators grouped into 5 domains – prescribing, dispensing, ordering reporting quality stock storage provide targeted on-the-job coaching. This study aimed determine inter-rater reliability (IRR)...
Dengue virus (DENV) infection is endemic in Nepal. Although rates are reported annually, little information available about the circulating viral serotypes and genotypes. Here, we report results of a multicentre cross-sectional study DENV genotypes sampled from individuals with suspected Nepal 2017. Of 50 patients sampled, 40 were serologically positive for NS1, 29 anti-DENV IgM, 21 IgG 14 by qRT-PCR. The three DENV-1, 2 3 detected there was no DENV-4. Positive samples serotyping subjected...
Background Nearly after 6 months of the spread Corona Virus Disease 19, along with world Nepal is still trying to control and prevent general population from acquiring it. With limited resources in manpower, technology evidence it has been a difficult battle. But time more understanding virus new detect are coming up. It major breakthrough diagnostic field as this helps us not only detecting but also mobilize our human resources. This comes where cases increasing at an alarming rate....
Human rabies is a preventable disease through post-exposure prophylaxis (PEP) in endemic countries where enzootic cycle of dog occurs. The COVID‑19 pandemic has induced an unprecedented challenge for under-funded and already stretched health‑care systems particularly low- middle-income countries, which are unfortunately bearing huge burden human rabies. An analysis hospital-based PEP data India, Nepal, Sri Lanka, Thailand, focus group discussion key informant interview have been carried out...
Chikungunya virus is an emerging arboviral disease that has been spreading rapidly across south Asia in recent years. Until recently, no chikungunya cases have reported Nepal. For the first time, we report three of infection Nepal
Abstract COVID‐19 has been associated with several neurological complications. We presented a case of Bell's palsy as possible complication infection. Further research should be conducted to clarify the association, correlation, or causality between and neuroimmunological diseases.
The long-term effects of COVID-19 among survivors is a matter concern. This research aimed to study persistent symptoms in post-COVID-19 patients attending follow-up clinic at tertiary care hospital Nepal. All patients, presenting the outpatient during duration six weeks, with history positive reverse transcriptase- polymerase chain reaction for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) least two weeks prior presentation, were included. ranged from 15 till 150 days mean 28...
Nepal is an endemic country for dengue infection with rolling of every 3 year's clear cyclic outbreaks exponential growth since 2019 outbreak and the virus gearing towards non-foci temperate hill regions. However, information regarding circulating serotype genotype not frequent. This research discusses on clinical features, diagnosis, epidemiology, among 61 suspected cases from different hospitals during window period 2017-2018 between two 2016 2019. E-gene sequences PCR positive samples...
Abstract Cutaneous leishmaniasis cases have increased dramatically in recent years Nepal. The study offers molecular identification of the Leishmania species using 40 patient’s aspiration biopsy samples, targeting markers kinetoplast minicircle DNA (kDNA) and internal transcribed spacer-1 (ITS1). Among molecularly diagnosed 22 cutaneous cases, L. donovani complex was identified 13 instances major 9 cases. ITS1 PCR positive 12 nested- kDNA (12/22), confirming seven five In addition, conclude...
Extended-spectrum β-lactamase (ESBL)- and AmpC-β-lactamase AmpC-Enterobacteriaceae have recently emerged as a public threat in the treatment of nosocomial well community-acquired infections. Very little information is currently available about its existence Nepal. We, therefore, aim to determine prevalence ESBL AmpC.During 6-month period (November 2014-April 2015), total 190 stool specimens from participants were obtained different population. Of 260 fecal isolates, 152 outpatient department...
Oropharyngeal candidiasis are the commonest fungal infections among HIV-positive patients. The main objective of this study was to explore biofilm-producing Candida species causing oropharyngeal HIV patients attending Sukraraj Tropical and Infectious Diseases Hospital (STIDH) in Kathmandu, Nepal.Oropharyngeal swabs were collected from between July December 2019. A total 174 cultured on Sabouraud Dextrose Agar (SDA). All samples inoculated SDA slants supplemented with chloramphenicol...
Coronavirus Disease 2019 (COVID-19) has challenged the health system worldwide, including low and middle income countries like Nepal. In view of rising number infections prediction multiple waves this disease, mortalities due to COVID-19 need be critically analyzed so that every possible effort could made prevent related in future. Main aim research was study about at a tertiary level hospital, This retrospective, observational included all inpatients from Sukraraj Tropical Infectious...
Scrub typhus is caused by Orientia tsutsugamushi, transmitted through bites of infected chiggers (larval mites). During the coronavirus disease 2019 (COVID-19) pandemic, reports co-infections with endemic pathogens are increasing around world. Disease similar clinical presentation may mask other diagnosis and increase morbidity mortality patients. We report co-infection between severe acute respiratory syndrome 2 (SARS-CoV-2) O. tsutsugamushi in a patient Nepal presenting fever, headache,...
Abstract Background Cutaneous leishmaniasis (CL) is endemic in 70 countries worldwide. Nepal considered non-endemic for CL and hence the control program targeted to visceral (VL) only. Here, we report emergence of cases different parts Nepal. Methods We analyzed VL reported Epidemiology Diseases Control Division (EDCD), Ministry Health Population, through District Information System 2 (DHIS-2) Early Warning Reporting (EWRS) during past 4 years (2016–2019). Any laboratory-confirmed case was...
Abstract Background Convalescent plasma therapy (CPT) and remdesivir (REM) have been approved for investigational use to treat coronavirus disease 2019 (COVID-19) in Nepal. Methods In this prospective, multicentered study, we evaluated the safety outcomes of treatment with CPT and/or REM 1315 hospitalized COVID-19 patients over 18 years 31 hospitals across was administered moderate, severe, or life-threatening infection. severe infections who were at high risk progression clinical worsening...
Introduction: Opportunistic bacterial and fungal infections are the major cause of morbidity mortality among immune suppressed HIV-positive patients. The main objective this study was to determine organisms causing respiratory their susceptibility commonly prescribed antimicrobials HIV patients attending a tertiary infectious disease hospital in Kathmandu. Methods: Sputum samples were collected from Sukraraj Tropical Infectious Disease Hospital (STIDH) August 2017 March 2018. A total 100...