A5000204109- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- melanin and skin pigmentation
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Nerve injury and regeneration
- Chromosomal and Genetic Variations
- Genetic and Kidney Cyst Diseases
- Parkinson's Disease Mechanisms and Treatments
Centre National de la Recherche Scientifique
2013-2024
Institut Curie
2021-2024
Université Paris Sciences et Lettres
2023-2024
Institut de Biologie Valrose
2017-2021
Université Côte d'Azur
2018-2021
Inserm
2018-2021
Fondation pour la Recherche Médicale
2013-2016
Institut de Pharmacologie Moléculaire et Cellulaire
2013-2016
Extracellular vesicles (EVs) facilitate the transfer of proteins, lipids, and genetic material between cells are recognized as an additional mechanism for sustaining intercellular communication. In epidermis, communication melanocytes keratinocytes is tightly regulated to warrant skin pigmentation. Melanocytes synthesize melanin pigment in melanosomes that transported along dendrites prior keratinocytes. EVs secreted by modulate pigmentation [(A. Lo Cicero et al. , Nat. Commun. 6 7506...
Parkinson's disease (PD) is a motor associated with the degeneration of dopaminergic neurons substantia nigra pars compacta. p53 major neuronal pro-apoptotic factor that at center gravity multiple physiological and pathological cascades, some which implying several key PD-linked proteins. Since up-regulated in PD-affected brain, we have examined its ability to regulate transcription α-synuclein, protein accumulates PD-related Lewy bodies.We show pharmacological genetic up-regulation...
The Hedgehog (Hh) morphogen gradient is required for patterning during metazoan development, yet the mechanisms involved in Hh apical and basolateral release how this influences short- long-range target induction are poorly understood. We found that depletion of GTPase Rab8 Hh-producing cells induces an imbalance between level apically laterally released Hh. This leads to non-cell-autonomous differential effects on expression genes, namely increase its short-range targets a concomitant...
ABSTRACT Hedgehog (Hh) is a conserved morphogen that controls cell differentiation and tissue patterning in metazoans. In Drosophila, the Hh signal transduced from G protein-coupled receptor Smoothened (Smo) to cytoplasmic signaling complex (HSC). How activated Smo translated into graded activation of downstream pathway still not well understood. this study, we show last amino acids tail Smo, combination with kinase 2 (Gprk2), bind regulatory domain Fused (Fu) highly activate its activity....
ABSTRACT Extracellular vesicles (EVs) facilitate the transfer of proteins, lipids and genetic material molecules between cells, are recognized as an additional mechanism for sustaining intercellular communication. In epidermis, communication melanocytes keratinocytes is tightly regulated to warrant skin pigmentation. Melanocytes synthetize melanin pigment in melanosomes that transported along dendrites prior keratinocytes. EVs secreted by modulate pigmentation (Lo Cicero et al., Nat. Comm....