A5087184743- Venous Thromboembolism Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Genetic factors in colorectal cancer
- Inflammatory Biomarkers in Disease Prognosis
- Angiogenesis and VEGF in Cancer
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Migraine and Headache Studies
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Central Venous Catheters and Hemodialysis
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Lymphoma Diagnosis and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014-2025
San Raffaele University of Rome
2015-2022
The Open University
2017-2022
IRCCS Ospedale San Raffaele
2010-2018
University of Rome Tor Vergata
2003-2017
Università degli studi di Cassino e del Lazio Meridionale
2017
Sapienza University of Rome
2003-2016
Uninett (Norway)
2015
Center for Cancer Research
2012-2014
Pancreatic cancer is one of the most intractable and least understood all human cancers. cancers fourth-leading cause cancer-related mortality in United States with less than 2% patients surviving for 5 yr. In an effort to help develop more effective treatment modalities pancreatic improve detection, we report animal model individual pancreatic-cancer patients. The involves orthotopic transplantation histologically intact specimens nude-mouse pancreas, which can result models that resemble...
Heterogeneity in the expression of tumor-associated antigens, as defined by binding monoclonal antibodies, is a characteristic common to most, if not all, human carcinoma cell populations. Antigen-negative cells within population can escape detection and therapy their failure bind appropriate antibody. Therefore, extent antigenic heterogeneity an important consideration when designing protocols for management cancer administration antibodies. One approach counteracting effect use clone A...
Several lines of investigation have revealed the apparent interplay between immune system host and many conventional, "standard-of-care" anticancer therapies, including chemotherapy small molecule targeted therapeutics. In particular, preclinical clinical studies demonstrated important role regulatory T cells (Tregs) in inhibiting responses elicited by immunotherapeutic regimens such as those based on vaccines or checkpoint inhibitors. However, how number immunosuppressive function Tregs...
The first version of the Standard PREanalytical Code (SPREC) was developed in 2009 by International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group to facilitate documentation communication most important preanalytical quality parameters different types biospecimens used research. This same has now updated SPREC 2.0, presented here, so that it contains more options allow recent technological developments. Existing elements have been fine tuned....
The epithelial-mesenchymal transition (EMT) is emerging as a critical factor for the progression and metastasis of carcinomas, well drug resistance. T-box transcription Brachyury has been recently characterized driver EMT in human carcinoma cells. purpose this study was to characterize potential target lung cancer therapy.The expression evaluated by PCR immunohistochemistry tumors adult normal tissues. gene copy number promoter methylation status were analyzed tumor tissues with various...
Hereditary breast cancer (BC), ovarian (OC), and pancreatic (PC) are the major BRCA-associated tumours. However, some BRCA1/2-wild-type (wt) patients with a strong personal and/or family history of need further genetic testing through multi-gene panel containing other high- moderate-risk susceptibility genes.
Neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios might represent a yet unrecognized risk factor for venous thromboembolism (VTE) in cancer out-patients receiving chemotherapy. Accordingly, this study was aimed at analyzing the significance of these novel markers prediction first VTE episode population representative general practice cohort. To purpose, mono-institutional cohort conducted to retrospectively analyze NLR PLR 810 consecutive with primary or relapsing solid start...
Conventionally, ischemic heart disease (IHD) is equated with large vessel coronary disease. However, recent evidence has suggested a role of compromised microvascular regulation in the etiology IHD. Because blood flow likely involves activity specific ion channels, and key factors involved endothelium-dependent dilation, we proposed that genetic anomalies channels or endothelial regulators may underlie We aimed to evaluate clinical impact single-nucleotide polymorphisms genes encoding for...
The epithelial–mesenchymal transition (EMT) has been implicated as an important process in tumor cell invasion, metastasis, and drug resistance. transcription factor brachyury recently described a driver of EMT human carcinoma cells. Brachyury mRNA protein expression was analyzed breast carcinomas benign tissues. role prognosis resistance the ability brachyury-specific T cells to lyse were also evaluated. Kaplan–Meier analyses used evaluate association between survival. All statistical tests...
To design a precision medicine approach aimed at exploiting significant patterns in data, order to produce venous thromboembolism (VTE) risk predictors for cancer outpatients that might be of advantage over the currently recommended model (Khorana score).Multiple kernel learning (MKL) based on support vector machines and random optimization (RO) models were used VTE (referred as machine [ML]-RO) yielding best classification performance training (3-fold cross-validation) testing...
Freshly isolated cells from patients with pleural or peritoneal effusions cytologically diagnosed as adenocarcinoma (n = 43), malignant nonepithelial neoplasms 10), and benign 8) were analyzed for expression of constitutive levels the tumor antigens TAG-72 [recognized by monoclonal antibody (MAb) B72.3] carcinoembryonic antigen (CEA) (recognized MAb COL-4) well class I II major histocompatibility (MHC) antigens, ability human interferons (Hu-IFNs) to enhance cell surface those measured...