A5056156986- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Autoimmune Bullous Skin Diseases
- Polyomavirus and related diseases
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Renal and Vascular Pathologies
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Imaging and Diagnostics
- Lysosomal Storage Disorders Research
- Diabetes and associated disorders
- Head and Neck Anomalies
- Biomedical Research and Pathophysiology
- Genomics and Rare Diseases
- Nephrotoxicity and Medicinal Plants
- Otitis Media and Relapsing Polychondritis
- Mast cells and histamine
- Molecular Biology Techniques and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IgG4-Related and Inflammatory Diseases
- Connective tissue disorders research
Christian Medical College, Vellore
2016-2025
Christian Medical College
2018-2025
AMRI Hospitals
2025
Creative Commons
2023
University of North Carolina at Chapel Hill
2019-2020
Arkana Laboratories
2020
Background IgA nephropathy (IgAN) is the most common form of glomerulonephritis globally, and a leading cause end-stage kidney disease (ESKD). In India, IgAN accounts for 10-15% biopsies, often with nephrotic syndrome renal impairment. Steroids are mainstay treatment, though role mycophenolate (MPA) less explored. This study investigated outcomes MPA in IgAN. Materials Methods retrospective included patients ≥18 years old biopsy-proven from January 1, 2010, to December 31, 2017, eGFR >15...
Anti-GBM and ANCA-mediated glomerulonephritis are common causes of crescentic glomerulonephritis. Dual or double-positive is rare, with few cases reported in the literature a worse prognosis. This case series six patients describes clinico-pathological features anti-glomerular basement membrane (anti-GBM GN) concomitant ANCA vasculitis assesses specific histopathological injury pattern this combined presentation. The had mean age 42 years, female predominance. Almost all presented haematuria...
Background and objectives Bacterial infection–related GN occurs concurrent to or after known unknown infections. It is important understand the clinical implications of bacterial isolates, antimicrobial resistance patterns, effect latency-based classification on kidney patient outcomes. Design, setting, participants, & measurements In total, 501 consecutive adults diagnosed with between 2005 2017 were included from a biopsy registry 15,545 patients at single center in South India,...
Glomerular Research And Clinical Experiments-IgA Nephropathy in Indians (GRACE-IgANI) is the first prospective South Asian IgAN cohort with protocolized follow-up and extensive biosample collection. Here we report baseline clinical, biochemical, histopathologic characteristics of GRACE IgANI calculate risk progression for cohort.
Mature cystic teratoma co-existing with a mucinous cystadenocarcinoma is an infrequently encountered entity only handful of cases reported till date. The possibilities in such case are either malignant transformation benign into adenocarcinoma or collision tumor between mature and tumour primary ovarian surface epithelial-stromal origin secondary from gastrointestinal tract tumour. importance distinguishing the two entities has significant bearing on subsequent therapeutic management. We...
<b><i>Background:</i></b> Atypia of undetermined significance or follicular lesion (AUS/FLUS) criterion in thyroid fine-needle aspirates (FNAs) has been a heterogeneous entity with much inter-observer variation. Sub-categorisation AUS/FLUS observed to play an effective role risk stratification. We aimed validate sub-categorisation correlation the spectrum malignancy. <b><i>Study Design:</i></b> Subjects included patients diagnosed between...
<ns5:p><ns5:bold>Background:</ns5:bold> The spectrum and outcomes of crescentic glomerulonephritis (Cr.GN) in South Asia is vastly different from that reported worldwide there a paucity information. aim the study was to demography, clinical presentation, histology predictors longitudinal Cr.GN this population.</ns5:p><ns5:p> <ns5:bold>Methods:</ns5:bold> An observational cohort renal biopsies performed largest tertiary center India over period 10 years (January 2006 December 2015) with ≥50%...
Abstract Aim Diabetic patients are prone to infections, thus making them a unique cohort at risk of developing bacterial infection‐related glomerulonephritis (IRGN). Methods In total, 1693 adult diabetic underwent kidney biopsy between 2005 and 2021 our tertiary care hospital in South India. Of these, 121 consecutive cases which met criteria IRGN were included this study. Results The mean age the was 53.1 ± 10.1 years 83/121 (68.5%) males. Majority (98.3%) had type 2 diabetes for median...
With significant advances in the understanding of transplant immunology and a reduction rejection rates, improvements kidney allograft survival have been seen. The problem recurrent denovo glomerular diseases after transplantation affecting graft outcomes remains is poorly characterized. This study aimed to analyze incidence, characteristics, glomerulonephritis (GN) Indian subcontinent. Data on patients who underwent transplants our hospital from 1971 2018 was analyzed. Patients had biopsy...
<b><i>Background:</i></b> Limited published literature exists on the utility and standardization of anti-phospholipase A2 receptor (anti-PLA2R) immunohistochemistry (IHC) for diagnosis primary membranous nephropathy (MN). The study aimed to validate anti-PLA2R IHC MN clinicopathological correlations in an Indian cohort. <b><i>Methods:</i></b> Subjects included patients with secondary diagnosed between January 2012 August 2014 adequate renal...
BK polyomavirus (BKPyV) infections with multi-organ involvement are rare. Here, we report for the first time whole genome sequencing data from a patient systemic BKPyV disease. She presented post stem cell transplantation graft-vs-host disease, suffered profound immunosuppression, and developed fatal disease of kidneys, lungs, pancreas. The lytic infection was caused by an episomal BKPyV-Ib strain canonical structural receptor encoding gene sequences. However, DNA all infected tissue sites...
Giant fibroepithelial polyp is a rare cause of ureteric/ureteropelvic junction (UPJ) obstruction. We report case giant in 32-year-old woman involving the whole length ureter, reaching up to UPJ which was clinically and radiologically considered be urothelial carcinoma. Frozen section showed polypoid lesion lined by urothelium with no evidence dysplasia or malignancy. Subsequently, nephroureterectomy done as there marked renal hydronephrosis it impossible separate from wall ureter....
Primary glomerular disease presenting with adult onset nephrotic syndrome are a major cause of chronic renal failure worldwide. The spectrum has undergone gradual change globally over the course time. However, there still exist regional differences in incidence primary diseases causing syndrome.To observe comparative analysis changing trends last five decades regards to Western and Indian literature.Subjects included patients age 18-80 years syndrome. Renal biopsies immunofluoroscence...
<title>Abstract</title> Introduction: Acute kidney injury (AKI) is no longer considered a single hit disease but part of spectrum that culminates in adverse renal and cardiovascular outcomes. What are the biopsy findings patient with persistent AKI/AKD (acute disease)? Are there characteristics which predict recovery. These questions this study addresses. Methodology: A retrospective was conducted analyzing all patients who underwent diagnosis acute from January 2021 to 2023 online hospital...
Abstract Introduction: Idiopathic membranous nephropathy (iMN) is a rare cause of nephrotic syndrome in children (1%–7%). Anti-phospholipase A2 receptor (PLA 2 R) antibody positivity kidney biopsy observed 52%–78% adults and 45% with iMN. The objectives the study are to analyze clinical profile outcome children, assess prevalence anti-PLA R immunohistochemistry (IHC) biopsy, correlate their presence disease characteristics. Methods: We reporting single-center retrospective conducted...
Introduction: Renal mesenchymal tumours are a subset of primary renal arising from the tissue in kidney. They heterogeneous group mostly benign that exhibit varied behaviours and molecular characteristics. Aim: To analyse wide spectrum histological subtypes, their unique clinical presentation, pathological features neoplasms. Materials Methods: This was retrospective crosssectional observational clinicopathological study conducted Department General Pathology, Christian Medical College,...