A5018237932- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Biosimilars and Bioanalytical Methods
- Asthma and respiratory diseases
- Cardiac electrophysiology and arrhythmias
- Acute Lymphoblastic Leukemia research
- HIV/AIDS drug development and treatment
- Systemic Lupus Erythematosus Research
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- HIV Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Eosinophilic Disorders and Syndromes
- Cardiovascular Disease and Adiposity
- Myasthenia Gravis and Thymoma
- Heart Failure Treatment and Management
- Biochemical and Molecular Research
- Blood Coagulation and Thrombosis Mechanisms
- Biotin and Related Studies
Maastricht University
2018-2024
Maastricht University Medical Centre
2017-2024
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University Medical Center
2018
Zuyderland Medisch Centrum
2016
Atrium Medisch Centrum Parkstad
2012
Cardiac troponin T (cTnT) is key in diagnosing myocardial infarction (MI) but also elevated end-stage renal disease (ESRD) patients. Specific larger cTnT proteoforms were identified for the acute phase of MI, while serum ESRD patients solely small fragments found. However, others allocated this to a pre-analytic effect due abundant thrombin generation serum. Therefore, we investigated various anticoagulation methods on composition and concentration compared MI
Background Cardiac troponin T ( cTnT ) is seen in many other conditions besides myocardial infarction, and recent studies demonstrated distinct forms of . At present, the vivo formation these different incompletely understood. We therefore performed a study on composition during course including coronary venous system sampling, close to its site release. Methods Results Baseline samples were obtained from multiple locations, peripheral artery vein 71 non- ST -segment-elevation infarction...
Figure 1 Bland-Altman plot of absolute hs-cTnT concentration differences before and after biotin depletion in 572 patients.The open dots are individual data points.The black line represents the median difference (0.00, 95% CI: -0.02 to 0.00) grey is reference line.
Abstract In a cohort of 106 HCV patients, hemoglobin (Hb) values were evaluated after 4 weeks (T After treatment, 78% the patients with normal ITPase activity anemic and 21% low (p<0.001). Stratified by genotype, percentages were: wt/wt 76%, wt/c.124+21A>C 46% (p=0.068), wt/c.94C>A 29% (p=0.021). At T This study is first to report that predicts development anemia during ribavirin treatment.
The role of cardiac troponins (cTn) have become increasingly important in diagnosing myocardial infarction (MI), especially patients without electrocardiogram abnormalities (1).
In HIV-infected patients, the enzyme Inosine triphosphate pyrophosphohydrolase (ITPase), involved in purine nucleotide homeostasis, was found to be decreased erythrocytes. Since analogues are pivotal HIV treatment, a better understanding of ITPase expression CD4 lymphocytes may lead metabolism and (adverse) effects.Cross-sectional, cohort, observational study.HIV-infected control patients above 18 years were included. All DNA samples genotyped for 2 functional ITPA SNPs; c.94C>A (rs1127354)...
Abstract The aim of this study was to assess inosine triphosphate (ITPase) expression in the different leukocyte populations present peripheral blood samples a nonimmune compromised control group. For purpose, multiparameter flow cytometric assay developed and performed ITPase subpopulations healthy volunteers ( n = 20). Qualitative assessed by determining percentage ITPase‐positive cells. Quantitative data were obtained measuring median fluorescent intensity (MFI). Subcellular localization...
Abstract Background Cardiac troponins (cTn) are the standard biomarkers to assess myocardial injury. Exercise can result in cTn elevations above upper reference limit (URL) which were previously associated with adverse health outcomes. However, it remains unclear if sport type influences prevalence of elevated concentrations. Purpose To compare cTnT and cTnI recreational athletes following completion a mass-participation running, cycling, or walking event. Methods We recruited ≥40 &lt;70...
Abstract Background Elevated concentrations of cardiac troponin (cTnT and cTnI), the preferred biomarker to diagnose myocardial infarction, can be detected in other (cardiac) conditions even post-exercise. Whether these exercise-induced elevations reflect a (patho)physiological process, as well their clinical implications, is unknown. In this preliminary study, pre- post-exercise high-sensitivity cTn (hs-cTnT hs-cTnI) were investigated long-distance walkers. Purpose Gain insight elevated...
Exercise can produce transient elevations of cardiac troponin (cTn) concentrations, which may resemble the cTn release profile myocardial infarction. Consequently, clinical interpretation postexercise (ie, values above 99th percentile upper reference limit) remains challenging and cause confusion. Therefore, insight into physiological versus pathological nature concentrations is warranted. We aim to (1) establish resting for recreational athletes engaged in walking, cycling or running...
Therapeutic drug monitoring of biological Tumor Necrosis Factor (TNF)-alpha inhibitors is critical importance. In this study, the performance practically advantageous chemiluminescent immunoassays Theradiag, assessing Infliximab and Adalimumab serum concentrations anti-drug antibodies (ADA) against these biologics, were compared to Enzyme-Linked Immuno-Sorbent Assays (ELISAs) from Sanquin Diagnostics.
Exercise induced eosinophil responses: normal cell counts with a marked decrease in responsivenessTo the Editor,Type II inflammation is characterized by elevated blood eosinophils which makes these cells an important diagnostic and treatment target in, for instance, severe asthma. Therefore, numbers are main inclusion criterion many clinical studies that investigated of eosinophilic asthma anti-IL5(Rα). However, there no consensus on cut-off values during inclusion, as evidenced high...