A5029782885- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Ion channel regulation and function
- Spinal Hematomas and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical Analysis and Sensing Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Blood donation and transfusion practices
- Autoimmune Neurological Disorders and Treatments
- Regulation of Appetite and Obesity
- Psychedelics and Drug Studies
- Neurological Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Mesenchymal stem cell research
- Neurosurgical Procedures and Complications
Marquette University
2016-2025
Columbia University
2022-2025
University of Maryland, Baltimore
2021-2024
Hess (United States)
2024
Columbia University Irving Medical Center
2023-2024
Columbia College
2022
Royal College of Physicians
2022
The authors sought to assess the prosocial, entactogen effects of ketamine. Pleasure from social situations was assessed in a sample participants with treatment-resistant depression randomized, double-blind, placebo-controlled studies, using four items Snaith-Hamilton Scale (SHAPS) at five time points over 1 week following treatment ketamine (0.5 mg/kg intravenously) or placebo. primary endpoint postinfusion self-reported pleasure on SHAPS pertaining situations, including item helping...
Cocaine use disorder (CUD) lacks FDA-approved treatments, partly due to the difficulty of creating therapeutics that target behavior-related neural circuits without disrupting signaling throughout brain. Recent evidence highlights therapeutic potential targeting gut-brain axis components, such as GLP-1 receptors, modulate with minimal central nervous system disruption. Like GLP-1, pituitary adenylate cyclase polypeptide (PACAP) is a component regulates behavior through network spanning gut...
Psychedelics act on intracellular serotonin receptors that are not accessible by alone.
Leptin signaling pathways, stemming primarily from the hypothalamus, are necessary for maintaining normal energy homeostasis and body weight. In both rodents humans, dysregulation of leptin leads to morbid obesity diabetes. Since resistance is considered a primary factor underlying obesity, understanding regulation could lead therapeutic tools provide insights into causality obesity. While actions in some hypothalamic regions such as arcuate nuclei have been characterized, less known about...
The importance of neuronal glutamate to synaptic transmission throughout the brain illustrates immense therapeutic potential and safety risks targeting this system. Astrocytes also release glutamate, clinical relevance which is unknown as range functions reliant on signaling from these cells hasn't been fully established. Here, we investigated system xc- (Sxc), a mechanism with an in vivo rodent expression pattern that restricted astrocytes. As most animals do not express Sxc, first compared...
Abstract Background Imbalance in prefrontal cortical (PFC) pyramidal neuron excitation:inhibition is thought to underlie symptomologies shared across stress-related disorders and neuropsychiatric disease, including dysregulation of emotion cognitive function. G protein-gated inwardly rectifying K + (GIRK/Kir3) channels mediate excitability medial PFC neurons, however the functional role these mPFC-dependent regulation affect, cognition, dynamics unknown. Methods In mice harboring a ‘floxed’...
Introduction: Remote ischemic lesions identified on MRI neuroimaging after intracerebral hemorrhage (ICH) may be related to microthrombosis. We sought evaluate whether hypercoagulability viscoelastic hemostatic assay relates these lesions. Methods: Spontaneous ICH patients enrolled in a single-center prospective observational study from 2009 2019 receiving baseline assay: Rotational Thromboelastometry (ROTEM) and were included. The presence count of DWI imaging >10 mm the outcome...
To evaluate sociodemographic and clinical factors associated with outcomes in patients hospitalized neuroinfectious diseases at three tertiary care centers New York City.
Background: Ischemic lesions on diffusion weighted imaging (DWI) occur in one-third of intracerebral hemorrhage (ICH). Due to conflicting prior studies, it is uncertain if the degree systolic blood pressure reduction increases risk. Patients with severe, chronic hypertension may be more vulnerable development ischemia after ICH due altered cerebral autoregulatory limits. Using cardiac remodeling as a biomarker for severe hypertension, we hypothesized that presence left ventricular...
Background: We identified that major ABO incompatible platelet transfusions are associated with poor intracerebral hemorrhage (ICH) outcomes, yet the driver for this relationship is unknown and does not appear to be related impaired hemostasis. Conversely, acute ICH patients known develop remote ischemic lesions on brain MRI. These but risk factors their formation unknown. explored whether these lesions. Methods: Consecutive spontaneous enrolled into a single-center, prospective cohort study...
Background: Ischemia on diffusion weighted imaging (DWI) after intracerebral hemorrhage (ICH) increases the risk of future ischemic stroke. Radiographic markers small vessel disease, including cerebral microbleeds (CMB), are associated with DWI lesions. Though cortical superficial siderosis (cSS) is also a hemorrhagic disease subtype, it unclear if cSS similarly relates to We hypothesized that would represent more severe phenotype and associate lesions ICH independent other markers. Methods:...
Background: We have previously identified that hemoglobin decrements and new-onset anemia during an intracerebral hemorrhage (ICH) hospitalization is frequent, rapid, associates with poor outcome. Though this association may be related to impaired cerebral oxygen delivery, it unclear whether these changes relate ischemia. investigated the relationship of over time ischemic lesions on brain MRI ICH hospitalization. Methods: Consecutive patients acute spontaneous enrolled into a single-center,...
OBJECTIVES/GOALS: We aim to discover safer and more effective therapeutics for CNS disorders. Current therapeutic development is hindered by dosing out drugs safe consumption. By identifying proteins with narrow functional roles in the brain (i.e., behavioral control), we can develop targeting these improved treatment safety efficacy. METHODS/STUDY POPULATION: focused on an evolutionarily new, non-neuronal, non-synaptic glutamate signaling mechanism, system xc- (Sxc). Sxc activity was...
OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cognitive produced through manipulating the activity of astrocytic release mechanism system xc-. METHODS/STUDY POPULATION: System xc- (Sxc) was eliminated by mutating gene Slc7a11 pronuclear injection zinc-finger nucleases into Sprague Dawley rat embryos...
Background: Little is known about the impact of sociodemographic and clinical factors on health outcomes in neuroinflammatory conditions. We sought to investigate relationships between factors, etiology, among patients with all-cause conditions.Methods: This retrospective cohort study was conducted January 1, 2010 December 31, 2017 at three large tertiary care centers New York City. Hospital-admitted aged ≥16 years meeting case definitions for conditions were included, data obtained from...