A5036146029- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Advanced Neuroimaging Techniques and Applications
- Family and Patient Care in Intensive Care Units
- Palliative Care and End-of-Life Issues
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Pneumothorax, Barotrauma, Emphysema
- Cardiovascular and Diving-Related Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Restraint-Related Deaths
- Pharmacological Effects and Toxicity Studies
- Hemodynamic Monitoring and Therapy
- Craniofacial Disorders and Treatments
- S100 Proteins and Annexins
- Intensive Care Unit Cognitive Disorders
- Mitochondrial Function and Pathology
- Anesthesia and Sedative Agents
- Simulation-Based Education in Healthcare
- Renal function and acid-base balance
- Foreign Body Medical Cases
Children's Hospital of Philadelphia
2020-2025
University of Pennsylvania
2020-2025
Philadelphia University
2019-2022
T1D Exchange
2018
Thomas Jefferson University
2012
To establish the clinical relevance of porcine model traumatic brain injury (TBI) using plasma biomarkers with diffusion tensor imaging (DTI) over 30 days, we performed a randomized, blinded, pre-clinical trial Yorkshire pigs weighing 7-10 kg. Twelve were subjected to Sham (n = 5) by skin incision or TBI 7) controlled cortical impact. Blood samples collected before injury, then at approximately 5-day intervals until days. Both groups also had DTI 24 h and days after injury. Plasma isolated...
Traumatic brain injury (TBI) is one of the leading causes morbidity and mortality in children. While left ventricular systolic dysfunction (LVSD) has been observed following TBI adults, very little known regarding it pediatric population. The aim this study was to evaluate frequency admission risk factors for TBI. authors hypothesized that cardiac would be associated with mortality. This a single-center retrospective observational from quaternary children's hospital. Pediatric patients who...
The purpose of this study is the development a porcine model carbon monoxide (CO) poisoning to investigate alterations in brain and heart mitochondrial function.Two group large animal CO poisoning.Laboratory.Ten swine were divided into two groups: Control (n = 4) 6).Administration low dose at 200 ppm over 90 min followed by 30 re-oxygenation room air. received air for 120 min.Non-invasive optical monitoring was used measure cerebral blood flow oxygenation. Cerebral microdialysis performed...
Introduction: Pediatric severe traumatic brain injury (TBI) is one of the leading causes disability and death. One classic pathoanatomic lesions following pediatric TBI diffuse (multifocal) axonal (DAI). In this single institution study, our overarching goal was to describe clinical characteristics long-term outcome trajectory patients with DAI. Methods: (<18 years age) who had DAI were retrospectively reviewed. We evaluated effect age, sex, Glasgow Coma Scale (GCS) score, early fever...
Traumatic brain injury (TBI) results in the generation of tau. As hyperphosphorylated tau (p-tau) is one major consequences TBI, targeting p-tau TBI may lead to development new therapy. Twenty-five pigs underwent a controlled cortical impact. One hour after were administered either vehicle (n = 13) or PNT001 12), monoclonal antibody for cis conformer phosphorylated at threonine 231. Plasma biomarkers neural assessed 14 days. Diffusion tensor imaging was performed day 1 and injury, these...
End-of-life (EoL) decision making during critical illness and injury is important in facilitating compassionate care that congruent with patient, family, societal expectations. Herein, we evaluate factors may effect induce variability practitioner EoL making, particularly years practice, use of advance directives (ADs), cost.An anonymous, online survey was offered to all active members the Eastern Association for Surgery Trauma (n = 1,359) June 2012. Demographic information a series...
Objective Pediatric sepsis screening is becoming the standard of care for children presenting to emergency department (ED) and has been shown improve recognition severe sepsis, but it unknown if these tools can predict progression disease. The objective this study was determine any elements a triage trigger tool were predictive hypotensive shock in ED with fever tachycardia. Methods This retrospective case-control ≤18 years an tachycardia, comparing those who went on develop subsequent 24...
Transcriptomic investigations of traumatic brain injury (TBI) can give us deep insights into the pathological and compensatory processes post-injury. Thus far, transcriptomic studies in TBI have mostly used microarrays focused on rodent models. However, a large animal model bears much stronger resemblance to human with regard anatomical details, mechanics injury, genetics, and, possibly, molecular response. Because advantages model, we investigated gene expression changes between injured...
Traumatic brain injury (TBI) causes significant white matter injury, which has been characterized by various rodent and human clinical studies. The exact time course of imaging changes in a pediatric after TBI its relation to biomarkers cellular function, however, is unknown. To study the major structures using valid model that comparable terms size anatomical features, we utilized four-week-old porcine with controlled cortical impact (CCI). Using diffusion tensor differential tractography,...
Summary We report the airway management of an 11‐year‐old boy with Treacher Collins syndrome. In three instances under general anaesthesia, ventilation via either anaesthesia facemask or supraglottic device proved virtually impossible except when neck was flexed, which runs counter to what is typically observed during routine anaesthetic care. this report, impact flexion on patient's demonstrated images obtained videolaryngoscopy and flexible endoscopy. It prudent manage airways using...
Introduction: Traumatic brain injury [TBI] is one of the leading causes morbidity and mortality in children. While left ventricular [LV] systolic cardiac dysfunction has been observed following TBI adults, very little known regarding pediatric population. We hypothesized that LV would be associated with mortality. Methods: This was a single-center retrospective study from quaternary children's hospital. Pediatric patients less than 18 years who had trans thoracic echocardiography obtained by...
Introduction: With an aging population, End of Life decision making (EoLDM) during critical illness and injury is important in facilitating compassionate care that congruent with patient, family, societal expectations. Hypothesis: Herein, we evaluate factors influence practitioner EoLDM, particularly years practice, use advanced directives cost consideration. Methods: An anonymous, online survey was offered to trauma & surgical practitioners via the active membership Eastern Association for...
Association of Emergency Department Length Stay and Outcomes in Pediatric Septic Shock Principal Investigator: Vanessa Mazandi, MD Co-Investigators: Alexandra Baker, MD; Melanie Silverman, MPH, Jackson Norton, Elliot Melendez, Background Early recognition initiation key processes pediatric sepsis have been shown to reduce mortality. The impact providing that care the emergency department (ED) vs. a rapid transition intensive unit (ICU) on outcomes is not known. primary objective this study...
Mazandi, Vanessa1; Ranganathan, Abhay2; Jang, David3; Hallowell, Thomas4; Delso, Nile5; Landis, William4; Chawla, Sanjeev6; McManus, Meagan4; Kilbaugh, Todd4 Author Information
Mazandi, Vanessa1; Jang, David2; Shin, Samuel3; Ranganathan, Abhay4; Delso, Nile5; Landis, William1; Chawla, Sanjeev3; Browne, Kevin2; Starr, Jonathan4; Cullen, Kacy3; Kilbaugh, Todd1 Author Information
Mazandi, Vanessa; Jang, David; Shin, Samuel; Ranganathan, Abhay; Delso, Nile; Landis, William; Starr, Jonathan; Kilbaugh, Todd Author Information
Mazandi, Vanessa; Lang, Shih-shan; Nishisaki, Akira; Beaulieu, Forrest; Gajjar, Avi; Tucker, Alexander; Storm, Phillip; Heuer, Greg; Zhang, Bingqing; Griffis, Heather; Ampah, Steve; Kirschen, Matthew; Topjian, Alexis; Yuan, Ian; Kilbaugh, Todd; Huh, Jimmy Author Information
Mazandi, Vanessa1; Jang, David2; Shin, Samuel3; Ranganathan, Abhay4; Delso, Nile5; Landis, William1; Starr, Jonathan4; Kilbaugh, Todd1 Author Information