A5002508985- Diabetes Management and Research
- Diabetic Foot Ulcer Assessment and Management
- Bone health and osteoporosis research
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cancer Immunotherapy and Biomarkers
- Obesity, Physical Activity, Diet
- Wound Healing and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Bone and Joint Diseases
- Bariatric Surgery and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Neuroblastoma Research and Treatments
- Bone health and treatments
- Health and Lifestyle Studies
- High Altitude and Hypoxia
- Vitamin D Research Studies
Garvan Institute of Medical Research
2013-2024
UNSW Sydney
2011-2024
St Vincent's Hospital Sydney
2014-2024
The University of Notre Dame Australia
2019-2024
St Vincent's Clinic
2019-2024
St Vincent's Hospital
2012-2023
St. Vincent's Birmingham
2015
Wagga Wagga Base Hospital
2010
Alterations in lipids muscle and plasma have been documented insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear.Nondiabetic sedentary individuals not treated lipid-lowering medications were studied (n = 51). Subjects body mass index (BMI) > 25 kg/m(2) 28) stratified based on median glucose infusion rate during hyperinsulinemic-euglycemic clamp into insulin-sensitive groups (above below median,...
OBJECTIVE Chronic low-grade inflammation is a feature of obesity and postulated to be causal in the development insulin resistance type 2 diabetes. The aim this study was assess whether overfeeding induces peripheral lean overweight humans, and, if so, it associated with increased systemic adipose tissue inflammation. RESEARCH DESIGN AND METHODS Thirty-six healthy individuals undertook 28 days by +1,250 kcal/day (45% fat). Weight, body composition, sensitivity (hyperinsulinemic-euglycemic...
The contribution of insulin resistance vs adiposity to bone mineral density (BMD), turnover, and fractures in humans remains unclear. To evaluate BMD turnover markers (BTMs) lean (n = 18) overweight/obese individuals with 17) without 34, insulin-sensitive [Obsensitive, n=15] or insulin-resistant [Obresistant, n=19] by homeostasis model assessment resistance) diabetes mellitus. Observational study. Insulin sensitivity was assessed using the hyperinsulinemic-euglycemic clamp; whole body fat...
Abstract Background Ipilimumab ( Y ervoy; B ristol‐ M yers S quibb) is a novel fully humanised monoclonal antibody that blocks cytotoxic T ‐lymphocyte antigen 4, an immune checkpoint molecule, to augment anti‐tumour ‐cell responses. It associated with significant immune‐related side‐effects including hypophysitis. Aim We reviewed the clinical and biochemical characteristics of 10 patients ipilimumab‐induced hypophysitis IH ), developed guidelines for early detection management based on our...
Sodium‐glucose co‐transporter 2 inhibitors ( SGLT2i ) are an increasingly prescribed class of medication for type diabetes mellitus. Euglycaemic diabetic ketoacidosis euDKA has been reported in association with use. Clinicians need to understand how recognise and treat this complication. We describe three cases patients treated .
Abstract Context The etiological mechanism of bile acid (BA) effects on insulin resistance and obesity is unknown. Objective This work aimed to determine whether plasma BAs are elevated in human and/or resistance. Methods observational study was conducted at an academic research center. Seventy-one adult volunteers formed 4 groups: lean insulin-sensitive (body mass index [BMI] ≤ 25 kg/m2, Homeostatic Model Assessment Insulin Resistance [HOMA-IR] < 2.0, n = 19), overweight/obese...
Abstract Aim To investigate the utility of calcaneal quantitative ultrasound compared with bone densitometry (DXA) in predicting incident low‐trauma fracture type 2 diabetes. Methods This retrospective cohort study included a subset participants Dubbo Osteoporosis Epidemiology Study who had concurrent and DXA measurement, comprising 809 people without diabetes 96 Fracture data been collected prospectively. Cox proportional hazard models receiver operating curves (ROC) were used to compare...
To determine whether routine blood glucose assessment of patients admitted to hospital from emergency departments (EDs) results in higher rates new diagnoses diabetes and documentation follow-up plans. Cluster randomised trial 18 New South Wales public district tertiary hospitals, 31 May 2011 - December 2012; outcomes March 2016. Patients aged years or more EDs. Routine at control intervention hospitals; automatic requests for glycated haemoglobin (HbA1c ) notification services about...
We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1(st) degree family history (FH+) of type 2 diabetes mellitus (T2DM) than matched control group without such (FH-) during voluntary overfeeding, implying co-inheritance susceptibilities to T2DM and obesity. have estimated the extent mode inheritance susceptibility increased adiposity FH+.Normoglycaemic participants were categorised either FH+ (≥1 relative T2DM, 50 F/30 M, age 45 ± 14 (SD) yr) or...
Background: Large cohort longitudinal studies have almost unanimously concluded that metabolic health in obesity is a transient phenomenon, diminishing older age. We aimed to assess the fate of insulin sensitivity per se over time overweight and obese individuals. Methods: Individuals studied using hyperinsulinaemic-euglycaemic clamp at Garvan Institute Medical Research from 2008 2010 (n = 99) were retrospectively grouped into Lean (body mass index (BMI) < 25 kg/m2) or overweight/obese...
In an era of increasing technology and telehealth utilization, three-dimensional (3D) wound cameras promise reliable, rapid, touch-free ulceration measurements. However, reliability data for commercially available devices in the diabetes foot service setting is lacking. We aimed to evaluate diabetes-related measurement using a 3D camera comparison routinely used ruler probe.Participants were prospectively recruited from tertiary interdisciplinary service. Ulcerations measured at each visit...
Abstract Background: Diabetes diagnosis is delayed 4–7 years and 50% are undiagnosed. Forty percent of hospitalized patients with any blood glucose level (BGL) ≥10 mmol/L have diabetes 3 months post‐discharge, yet less than 5% detected in hospital. We review identification of, responses to, hyperglycaemia inpatients at a teaching Methods: The world's largest retrospective medical records for venous BGL ≥11.1 without known over 12 (2005–2006). primary outcome was recognition hyperglycaemia;...
Insulin resistance (IR) is one of the earliest predictors type 2 diabetes. However, diagnosis IR limited. High fat fed mouse models provide key insights into IR. We hypothesized that early features are associated with persistent changes in gene expression (GE) and endeavored to (a) develop novel methods for improving signal:noise analysis human GE using models; (b) identify a motif accurately diagnoses humans; (c) biology humans.We integrated muscle data longitudinal developed an unbiased...
BackgroundDiabetic patients are commonly hyperglycaemic on presentation.Admission hyperglycaemia is associated with adverse outcomes, particularly prolonged hospitalisation.Improving inpatient glycaemia may reduce length of hospital stay (LOS) in diabetic patients. AimsTo determine whether in-hospital recognition and treatment admission reduced LOS. MethodsMedical records were reviewed from 1 November 2011 to 31 May 2012 for 162 admitted a blood glucose level (BGL) ≥11.1mmol/L.In-hospital...
Treated human immunodeficiency virus (HIV) infection is associated with high rates of type 2 diabetes mellitus (DM), metabolic syndrome and central obesity/body fat partitioning disorders. To our knowledge, there are no available data comparing care in people both HIV+DM versus DM alone (DM-controls) within the same service evaluating if benchmarked standards being met HIV+DM. This study evaluated frequency that American Diabetes Association (ADA) (targets for HbA1c, blood pressure, lipid...