A5009833685- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Pain Management and Placebo Effect
- Adipokines, Inflammation, and Metabolic Diseases
- Streptococcal Infections and Treatments
- Cardiovascular and exercise physiology
- Regulation of Appetite and Obesity
- Cancer, Lipids, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Lipid metabolism and disorders
- Education and Character Development
- Chronic Myeloid Leukemia Treatments
- Effects and risks of endocrine disrupting chemicals
- Lipid metabolism and biosynthesis
- Healthcare Systems and Practices
- Chemical Safety and Risk Management
- Clinical practice guidelines implementation
- Cardiac Arrest and Resuscitation
- Connective tissue disorders research
Udayana University
2020-2024
Charité - Universitätsmedizin Berlin
2024
Thai Moogambigai Dental College and Hospital
2024
Dr. M.G.R. Educational and Research Institute
2024
Baker Heart and Diabetes Institute
2011-2016
University of Arizona
1987-2014
The University of Melbourne
1991-2011
Data61
2011
The Alfred Hospital
2011
Monash University
2011
Objective— Traditional risk factors for coronary artery disease (CAD) fail to adequately distinguish patients who have atherosclerotic plaques susceptible instability from those more benign forms. Using plasma lipid profiling, this study aimed provide insight into pathogenesis and evaluate the potential of profiles assess future plaque instability. Methods Results— Plasma containing 305 lipids were measured on 220 individuals (matched healthy controls, n=80; stable angina, n=60; unstable...
Alterations in lipids muscle and plasma have been documented insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear.Nondiabetic sedentary individuals not treated lipid-lowering medications were studied (n = 51). Subjects body mass index (BMI) > 25 kg/m(2) 28) stratified based on median glucose infusion rate during hyperinsulinemic-euglycemic clamp into insulin-sensitive groups (above below median,...
Fourteen GH-deficient (GHD) adults were compared with 12 age-, sex-, and body mass index-matched control subjects using a baseline tritiated glucose equilibration period euglycemic-hyperinsulinemic (approximately 55 mU/L) clamp in conjunction paired muscle biopsies for measurement of glycogen synthase fractional velocity (FV0.1). Despite similar basal rates total disposal (Rd), there was 64% reduction the insulin-stimulated rise (delta) Rd GHD to that controls [16.6 +/- 2.8 vs. 44.7 6.0...
The effect of 3 months low dose (120 micrograms/kg.week or 0.24 IU/kg.week) recombinant human GH (rhGH) treatment on glucose tolerance, insulin secretion, and insulin- glucose-mediated disposal was examined in 10 GH-deficient adults. frequently sampled iv tolerance test performed at baseline after 1 week rhGH therapy analyzed by the minimal model method Bergman to provide estimates decay rate, first second phase secretion (phi phi 2), fractional clearance insulin, insulin-mediated disposal....
We have previously reported that GH-deficient (GHD) adults are severely insulin resistant.In the present study, we determined effects of 6 months (n ϭ 7) and 24 (long-term; n 11) recombinant human GH (rhGH) therapy (ϳ0.22 IU/kg.week) on body composition fasting biochemical (including lipid) parameters, baseline insulin-stimulated: 1) rates hepatic glucose production, total disposal (Rd), glycolysis (GF) storage (GS); 2) skeletal muscle processing [using euglycemic-hyperinsulinemic (ϳ60 mU/L)...
While chronic obesity is associated with alterations in circulating glycerolipids, sphingolipids and plasmalogens, the effects of short-term overfeeding humans are unclear.Healthy individuals (n = 40) were overfed by 1,250 kcal day(-1) for 28 days. Insulin sensitivity (hyperinsulinemic-euglycemic clamp), abdominal fat distribution serum lipidomics (mass spectrometry) assessed.Overfeeding increased liver fat, insulin resistance, C-reactive protein urinary F2-isoprostanes. HDL (11% ± 2%, P <...
Human bites and common lacerations are frequent in certain residential groups institutions for the care of developmentally disabled individuals. We screened records such an institution studied course outcome 434 human bite wounds 803 same group clients. Infection developed 13.4% lacerations, 17.7% (chi 2 = 3.474; p greater than 0.06). Prophylactic antibiotics were administered after 14.0% wounds, 3.2% lacerations. supervened prophylactic 29.5% 34.6% No patient with a wound required...
We determined the impact of variable insulinemia and glycemia on in vivo partitioning glucose effectiveness (GE) insulin sensitivity (SI) vitro intracellular processing metabolism. Six somatostatin- [3-3H]glucose-infused dogs underwent euglycemic hyperglycemic clamps at four physiological (Ins) levels before a muscle biopsy. From rates infusion (GINF), total disposal (Rd), glycolysis (GF), storage (GS), plots delta GINF, Rd, GS vs. log Ins concentration were found to be linear for each dog,...
The increased energy required for acute moderate exercise by skeletal muscle (SkM) is derived equally from enhanced fatty acid (FA) oxidation and glucose oxidation. Availability of FA also influences contracting SkM metabolic responses. Whole body turnover responses were determined in paired dog studies during 1) a 30-min (maximal oxygen consumption approximately 60%) test vs. 60-min low-dose 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR) infusion, 2) 150-min AICAR infusion...
The effect of diabetes and exercise on skeletal muscle (SkM) AMP-activated protein kinase (AMPK)α1 -α2 activities site-specific phosphorylation acetyl-CoA carboxylase was examined in the same six dogs before alloxan (35 mg/kg)-induced (C) after 4-5 wk suboptimally controlled hyperglycemic hypoinsulinemic (DHG) presence absence 300-min phlorizin (50 μg·kg -1 ·min )-induced “normoglycemia” (DNG). In each study, dog underwent a 150-min [3- 3 H]glucose infusion period, followed by 30-min...
The separate impacts of the chronic diabetic state and prevailing hyperglycemia on plasma substrates hormones, in vivo glucose turnover, ex skeletal muscle (SkM) during exercise were examined same six dogs before alloxan-induced diabetes (prealloxan) after 4-5 wk poorly controlled hyperglycemic (HGD) absence presence approximately 300-min phlorizin-induced (glycosuria mediated) normoglycemia (NGD). For each treatment state, 15-h-fasted dog underwent a primed continuous 150-min infusion...
To determine the impact of variable plasma insulin concentrations and glycemia on partitioning whole body glucose metabolism between glycolysis storage, we estimated endogenous hepatic production rates in vivo glycolytic flux (GF) storage (GS) six normal dogs from generation tritiated water (3H2O) [3-3H]glucose specific activity during 150 min somatostatin euglycemic (E) hyperglycemic (H) clamps at hypoinsulinemic, basal, intermediate, high levels. During both E H clamps, overall GF GS...
AMPK plays a central role in influencing fuel usage and selection. The aim of this study was to analyze the impact low-dose AMP analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribosyl monophosphate (ZMP) on whole body glucose turnover skeletal muscle (SkM) metabolism. Dogs were restudied after prior 48-h fatty acid oxidation (FA(OX)) blockade by methylpalmoxirate (MP; 5 x 12 hourly 10 mg/kg doses). During basal equilibrium period (0-150 min), fasting dogs (n = 8) infused with [3-(3)H]glucose...
Introduction: Nasopharyngeal carcinoma is a disease that may cause mortality and shows with many clinical symptoms in the nose, ear, eyes, nervous system. This study aimed to help workers decide which patient these must be referred or not. Methods: Primary data from ENT Clinic of Prof. Dr. dr. I.G.N.G Ngoerah was used January 2022 March 2022. Descriptive analysis logistic regression were employed describe relationship between patients’ demographic, diagnosis NPC histopathology examination....