A5103053147- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Cancer Risks and Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Polyamine Metabolism and Applications
- Nutrition, Genetics, and Disease
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Tendon Structure and Treatment
- Human-Animal Interaction Studies
- Neuroendocrine Tumor Research Advances
- Balance, Gait, and Falls Prevention
- Infant Development and Preterm Care
- Attention Deficit Hyperactivity Disorder
University of Arizona
2015-2025
University of Arizona Cancer Center
2015-2025
Diakonessenhuis hospital
2023
Collaborative Research Group
2016
UCLA Medical Center
2014
Stanford University
2014
Ronald Reagan UCLA Medical Center
2014
American Cancer Society
2014
Stony Brook University
2014
Albert Einstein College of Medicine
2014
Abstract Healthy lifestyle behaviors are recommended to reduce cancer risk and overall mortality. Adherence cancer-preventive health subsequent has not been evaluated in a diverse sample of postmenopausal women. We examined the association between American Cancer Society (ACS) Nutrition Physical Activity Prevention Guidelines score incident cancer, cancer-specific mortality, all-cause mortality 65,838 women enrolled Women's Health Initiative Observational Study. ACS guidelines scores (0–8...
Objectives To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. Design Prospective cohort study. Setting Women's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. Participants Women aged 50 to 79 (N = 134,961) data one or more measures. Measurements Physical was assessed using the short‐form RAND‐36 baseline annually beginning 2005 for all WHI...
It has been previously reported that ursodeoxycholic acid (UDCA), a therapeutic bile acid, reduced risk for advanced colorectal adenoma in men but not women. Interactions between the gut microbiome and fecal composition as factor cancer neoplasia have postulated evidence is limited to small cohorts animal studies. Using banked stool samples collected part of phase III randomized clinical trial UDCA prevention adenomatous polyps, we compared change after 3-year intervention subset...
Abstract Lessons learned Intravenous paricalcitol did not improve the efficacy of pembrolizumab, likely related to short half-life. Background Immunotherapy has limited benefit in treatment advanced pancreatic cancer with tumor microenvironment playing a key role immune resistance. In preclinical studies, vitamin D receptor (VDR) agonists have been shown sensitize tumors PD-1 blockade. Methods This was randomized, double-blinded, placebo-controlled, phase II trial evaluate pembrolizumab or...
Evidence suggests that individuals who report fewer total hours of sleep are more likely to be overweight or obese. Few studies have prospectively evaluated weight‐loss success in relation reported quality and quantity. This analysis sought determine the association between characteristics weight loss obese women enrolled a randomized clinical trial program. We hypothesized overweight/obese women, significant would demonstrated frequently better Pittsburgh Sleep Quality Index (PSQI) Global...
Abstract Physical activity is protective against colon cancer, whereas colonic bile acid exposure a suspected risk factor. Although likely related, the association between physical and levels has not been well-studied. Furthermore, effect of triglycerides, which are known to modify levels, on this relationship investigated. We conducted cross-sectional analysis baseline fecal for 735 colorectal adenoma formers obtained from participants in phase III ursodeoxycholic chemoprevention trial....
Published data support the presence of etiologic heterogeneity by breast tumor subtype, but few studies have assessed this in Hispanic populations.We subtype prevalence and associations between reproductive factors subtypes 1,041 women Mexican descent enrolled a case-only, binational cancer study. Multinomial logistic regression comparing HER2(+) tumors triple-negative (TNBC) to luminal A was conducted.Compared with tumors, those later age at first pregnancy were less likely TNBC [OR, 0.61;...
Historically, marital status has been associated with lower mortality and transitions into marriage were generally accompanied by improved health status. Conversely, divorce increased mortality, possibly mediated changes in behaviors. This study uses data from a prospective cohort of 79,094 postmenopausal women participating the Women's Health Initiative Observational Study (WHI-OS) to examine relationship between transition indicators (blood pressure, waist circumference, body mass index...
Obesity, often defined as a body mass index (BMI; weight (kg)/height (m)(2)) of 30 or higher, has been associated with mortality, but age-related composition changes can be masked by stable BMI. A subset Women's Health Initiative participants (postmenopausal women aged 50-79 years) enrolled between 1993 and 1998 who had received dual-energy x-ray absorptiometry scans for estimation total fat (TBF) lean (LBM) (n = 10,525) were followed 13.6 (standard deviation, 4.6) years to test associations...
Objective Studies evaluating the relationship between body mass index (BMI) and mortality demonstrate a U‐shaped association. To expand, this study evaluated adiposity indices, shape (ABSI) (BAI), in 77,505 postmenopausal women. Methods A prospective cohort analysis was conducted Women's Health Initiative to ascertain independent relationships indices order inform on clinical usefulness of alternate measures risk. ABSI (waist circumference (cm)/[BMI 2/3 × height (cm) 1/2 ]), BAI (hip...
Of postpartum women, 15%-20% retain ≥ 5 kg of their gestational weight gain, increasing risk for adult gain. Postpartum women are also in a persistent elevated inflammatory state. Both factors could increase the obesity-related chronic disease. We hypothesized that breastfeeding randomized to Mediterranean-style (MED) diet 4 months would demonstrate significantly greater reductions body weight, fat, and inflammation than U.S. Department Agriculture's (USDA) MyPyramid Pregnancy Breastfeeding...
Abstract Purpose: Ursodeoxycholic acid (UDCA) was one of the earliest agents investigated as a drug for colorectal cancer prevention. However, UDCA failed to show efficacy prevent development adenomas in large, phase III, randomized, placebo-controlled trial. We re-evaluated effect men and women separately, based on sex-specific differences bile metabolism suspected variation etiologic factors contributing risk. Experimental Design: conducted secondary analysis adenoma (n = 804) 388)....
To examine prospective associations between changes in physical activity (PA) and performance measures (PPMs) over 6 years older women.Prospective cohort study.Forty clinical centers the United States.Women aged 65 (mean age 69.8) enrolled Women's Health Initiative Clinical Trials with gait speed, timed chair stand, grip strength, self-reported recreational PA data assessed at baseline (1993-98) follow-up Years 1, 3, (N = 5,092).Mixed-effects linear regression models were used to determine...
Breast cancer is the number one cause of can- cer deaths among Hispanic women in United States, and Mexico, it recently became primary deaths. This malign- nancy represents a poorly understood un- derstudied disease women. The ELLA Binational Cancer Study was es- tablished 2006 as multi-center study to as- sess patterns breast tumor markers, clinical characteristics, their risk factors Mexican descent. We describe design implementation provide factor comparison between U.S. those Mexico...
Abstract Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in conversion of cholesterol to bile acids, is a postulated gene modifier colorectal cancer risk and target for therapeutic acid, ursodeoxycholic acid (UDCA). We investigated associations between CYP7A1 polymorphisms fecal adenoma (CRA), UDCA efficacy CRA prevention. Seven tagging, single-nucleotide (SNP) were measured 703 (355 UDCA, 348 placebo) participants phase III chemoprevention trial, which 495 had known baseline...
Abstract Research suggests that women may have poorer tobacco cessation outcomes than men; however, the literature is somewhat mixed. Less known about gender differences in within quitline settings. This study examined utilization of services (i.e., coaching sessions, pharmacotherapy) and among callers to Arizona Smokers’ Helpline (ASHLine). The sample included enrolled ASHLine between January 2011 June 2016. We tracked number completed sessions. At 7-month follow-up, retrospectively...
To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women.Postmenopausal women stage I-III who were taking adjuvant inhibitors complained of pain enrolled (n = 6). Postmenopausal no history cancer, hormone treatment, or served controls 7). All subjects had bilateral hands wrists evaluated gray-scale power...