A5057688267- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Andrographolide Research and Applications
- Plant responses to water stress
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemical compounds biological activities
- Cancer, Hypoxia, and Metabolism
- vaccines and immunoinformatics approaches
- Tannin, Tannase and Anticancer Activities
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Ziziphus Jujuba Studies and Applications
- Pomegranate: compositions and health benefits
- Plant Molecular Biology Research
- Proteoglycans and glycosaminoglycans research
- Tea Polyphenols and Effects
- Plant tissue culture and regeneration
- Machine Learning in Bioinformatics
- Wood and Agarwood Research
- Advancements in Transdermal Drug Delivery
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds in Plants
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
Kyung Hee University
2019-2024
Anticancer peptides (ACPs) are promising therapeutic agents for targeting and killing cancer cells. The accurate prediction of ACPs from given peptide sequences remains as an open problem in the field immunoinformatics. Recently, machine learning algorithms have emerged a tool helping experimental scientists predict ACPs. However, performance existing methods still needs to be improved. In this study, we present novel approach ACPs, which involves following two steps: (i) We applied two-step...
Triterpenoids are natural bioactive compounds that demonstrate cytotoxic and chemopreventive activities by inhibiting various intracellular signals transcription factors. Despite their efficacy, triterpenoid chemotherapeutics face significant challenges in cancer therapy because of poor aqueous solubility, which restricts the utilization potent drug variants. Consequently, there is a pressing need to develop solubilized form encapsulated within mechanically robust biomaterials, facilitate...
The family Thymelaeaceae, which includes huge evergreen trees that are sparsely distributed in tropical rainforests, the genus Aquilaria. Numerous medical conditions, including inflammation, cancer, and oxidative stress have been traditionally treated using Aquilaria agallocha malaccensis. In this study, we evaluated silico biological activity with A. malaccensis sample for more conformation. Raw 264.7 macrophage cells HacaT were used, together MTT, ROS, NO, wound healing assays, to...
Dendropanax morbifera (DM), a medicinal plant, is rich in polyphenols and commonly used to treat cancer, inflammation, thrombosis. However, date, no study has been conducted on DM regarding the enormous drift of secondary metabolites plants different regions Republic Korea their effects antiobesity, explore compounds that play an important role two major obesity-related pathways. Here, we present in-depth samples collected from three [Jeju Island (DMJ), Bogildo (DMB), Jangheung (DMJG)]. We...
SARS-CoV-2 is a novel coronavirus that emerged as an epidemic, causing respiratory disease with multiple severe symptoms and deadly consequences. ACE-2 TMPRSS2 play crucial synergistic roles in the membrane fusion viral entry of (COVID-19). The spike (S) protein binds to receptor for entry, while proteolytically cleaves S into S1 S2 subunits, promoting fusion. Therefore, are potential drug targets treating COVID-19, their inhibition promising strategy treatment prevention. This study...
Ginsenoside Rh1 (G-Rh1), a possible bioactive substance isolated from the Korean Panax ginseng Meyer, has wide range of pharmacological effects. In this study, we have investigated anticancer efficacy G-Rh1 via in silico and vitro methodologies. This study mainly focuses on two metastatic regulators, Rho-associated protein kinase 1 (ROCK1) RhoA, along with other standard apoptosis regulators. The ROCK1 is member active serine/threonine family that crucial for many biological processes,...
Green synthesis of metal nanoparticles from medicinal plants has provided a broad scope in biomedical research and functional food formulations due to low toxicity. Dendropanax morbifera (DM) is versatile traditional medicine used for various inflammatory diseases its extensive antioxidant activity. We investigated DM as natural capping agent Zn2+ ions coloaded it with tryptophan penetration antiobesity behavior. zinc oxide (DM-ZnO NPs) were prepared then entrapped (DM-ZnO-Try nanoemulsion...
Despite the contemporary advancements in field of science and medicine, combating coronavirus disease 2019 (COVID-19) is extremely challenging many aspects as virus keeps spreading mutating rapidly. As there no effective conclusive drug therapy to date, it crucial explore plant-based natural compounds for their potential inhibit SARS-CoV-2 (severe acute respiratory syndrome 2). Recent research highly focuses on screening various phytochemicals elucidate anti-viral efficacy. However, very few...
Obesity is associated with chronic inflammation, which can disrupt bone homeostasis, leading to osteoporosis. In this study, we investigated the potential antiobesogenic and osteoprotective effects of fermented pomegranate (PG-F) juice by elucidating its impact on Wnt/β-catenin signaling pathway. First, employing molecular docking dynamics, confirmed stable binding ellagic acid gallic target proteins for both obesity vitro experiments 3T3-L1 adipocytes demonstrated that PG-F effectively...
Ginseng and ginsenosides have been reported to various pharmacological effects, but their efficacies depend on intestinal absorption. Compound K (CK) is gaining prominence for its biological pharmaceutical properties. In this study, CK-enriched fermented red ginseng extract (DDK-401) was prepared by enzymatic reactions. To examine pharmacokinetics, a randomized, single-dose, two-sequence, crossover study performed with eleven healthy Korean male female volunteers. The volunteers were...