Triterpenoids are natural bioactive compounds that demonstrate cytotoxic and chemopreventive activities by inhibiting various intracellular signals transcription factors. Despite their efficacy, triterpenoid chemotherapeutics face significant challenges in cancer therapy because of poor aqueous solubility, which restricts the utilization potent drug variants. Consequently, there is a pressing need to develop solubilized form encapsulated within mechanically robust biomaterials, facilitate...

Nanoscience is a multidisciplinary skill with elucidated nanoscale particles and their advantages in applications to various fields. Owing economical synthesis, biocompatible nature, widespread biomedical environmental applications, the green synthesis of metal nanoparticles using medicinal plants has become potential research area functional food formulations. Gynostemma pentaphyllum (GP) been extensively used traditional Chinese medicine cure several diseases, including diabetes mellitus...

The family Thymelaeaceae, which includes huge evergreen trees that are sparsely distributed in tropical rainforests, the genus Aquilaria. Numerous medical conditions, including inflammation, cancer, and oxidative stress have been traditionally treated using Aquilaria agallocha malaccensis. In this study, we evaluated silico biological activity with A. malaccensis sample for more conformation. Raw 264.7 macrophage cells HacaT were used, together MTT, ROS, NO, wound healing assays, to...

The unique and tailorable physicochemical features of zinc oxide nanoparticles (ZnO-NPs) synthesized from green sources make them attractive for use in cancer treatment. Hydroponic-cultured ginseng-root-synthesized ZnO-NPs (HGRCm-ZnO NPs) were coated with O-carboxymethyl chitosan (CMC) polymer, which stabilized enhanced the biological efficacy nanoparticles. Nanoparticles characterized by X-ray diffraction (XRD), UV-Vis spectroscopy, transmission electron microscopy (TEM), Fourier-transform...

SARS-CoV-2 is a novel coronavirus that emerged as an epidemic, causing respiratory disease with multiple severe symptoms and deadly consequences. ACE-2 TMPRSS2 play crucial synergistic roles in the membrane fusion viral entry of (COVID-19). The spike (S) protein binds to receptor for entry, while proteolytically cleaves S into S1 S2 subunits, promoting fusion. Therefore, are potential drug targets treating COVID-19, their inhibition promising strategy treatment prevention. This study...

Terminalia ferdinandiana (Kakadu plum) is an Australian native plant that has recently gained the attention of researchers due to its highly antioxidant compounds have substantial health benefits. To raise value, in this study, it used for first time synthesize ZnO nanoparticles anti-lung cancer and anti-inflammatory activities. The formation KKD-ZnO-NPs (ZnO particles obtained from Kakadu were confirmed using a UV-Visible spectrophotometer. Fourier transform infrared (FTIR) spectroscopy...

Postmenopausal women experience several symptoms, including inflammation and a sharp rise in oxidative stress caused by estrogen deprivation. Although replacement therapy (ERT) is generally regarded as an effective treatment for menopause, it has been used less frequently due to some adverse effects high costs. Therefore, there immediate need develop herbal-based that affordable low-income populations. Acordingly, this study explored the estrogen-like properties of methanol extracts from...

Phenolics are phytochemicals in plants, fruits, and vegetables have potential health-promoting efficacies. However, mostly available as a complex form. So, to increase the contents nutritional value of phenolic compounds, fermentation is most readily used food industry. Especially, hydrolyzable tannins present pomegranate that can be liberated into monomolecular substances, which enhances biological activity. Thus, this study aims convert ellagic acid by using Tannin acyl hydrolase (TAH)...

Ginsenoside Rh1 (G-Rh1), a possible bioactive substance isolated from the Korean Panax ginseng Meyer, has wide range of pharmacological effects. In this study, we have investigated anticancer efficacy G-Rh1 via in silico and vitro methodologies. This study mainly focuses on two metastatic regulators, Rho-associated protein kinase 1 (ROCK1) RhoA, along with other standard apoptosis regulators. The ROCK1 is member active serine/threonine family that crucial for many biological processes,...

Biogenic synthesis using medicinal plants has less harmful effects as compared to the chemical of nanoparticles. Here, for first time, we successfully demonstrated eco-friendly zinc oxide nanoparticles (ZnO NPs) an aqueous extract Cissus antractica. The green method offers great potential developing new medications that enhance drug bioavailability. current work highlighted cytotoxicity, cell death, and routes apoptosis in lung cancer cells (A549) inflammatory through synthesizing from...

Orchid-flower-shaped ZnO nanomaterials were successfully synthesized via green synthesis and an eco-friendly approach using aqueous extract of Lycium chinense fruit as a reducing capping agent. The orchid-flower-shaped (LC-ZnO/OF) nanoparticles (NPs) characterized different analytical methods through X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), field emission scanning (FE-SEM), photoelectron spectroscopy (XPS),...

The family Bignoniaceae includes Handroanthus impetiginosus trees, which are sparsely distributed in the northeast of Brazil. Natural products play a vital role discovery drugs for various diseases. Many plants have been used as sources medicines because their chemical diversity and potent bioactivity. has traditionally to cure wide range illnesses, such cancer, oxidative stress, inflammation. This work highlights cytotoxicity, cell death, routes apoptosis lung cancer cells (A549)...

This study focused on developing Panos nanoemulsion (P-NE) and enhancing the anti-inflammatory efficacy for treatment of inflammation. The effects P-NE were evaluated in terms Nitric oxide (NO production) Lipopolysaccharide (LPS), induced RAW 264.7 cells, Reactive oxygen species (ROS) generation using Human Keratinocyte cells (HaCaT), quantitative polymerase chain reaction (qPCR) analysis. Sea buckthorn oil, Tween 80, span 80 used optimize process. extract (P-Ext) was prepared fermentation...

Green products have excellent potential for discovering and producing new medicinal products. In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants sources. This eco-friendly approach was used in research to biosynthesize zinc oxide nanoparticles (ZnO NPs) Cissus antractica plant. The present study aims examine cell cytotoxicity, death, pathways apoptosis lung cancer cells (A549) inflammation properties treated with...

Green products have excellent potential for discovering and producing new medicinal products. In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants sources. This eco-friendly approach was used in research to biosynthesize zinc oxide nanoparticles (ZnO NPs) Cissus antractica plant. The present study aims examine cell cytotoxicity, death, pathways apoptosis lung cancer cells (A549) inflammation properties treated with...

Ginseng and ginsenosides have been reported to various pharmacological effects, but their efficacies depend on intestinal absorption. Compound K (CK) is gaining prominence for its biological pharmaceutical properties. In this study, CK-enriched fermented red ginseng extract (DDK-401) was prepared by enzymatic reactions. To examine pharmacokinetics, a randomized, single-dose, two-sequence, crossover study performed with eleven healthy Korean male female volunteers. The volunteers were...

Rosuvastatin calcium tablets are mainly five brands obtainable that is a synthetic compound which decreases the number of lipid portion placed as hypercholesterolemia treatment. The major purpose this study to measure stability different on stress condition. Degradation system procedure includes degradation drug particles and ingredients at specific conditions. Those generated into products can be studied evaluate quality efficacy formulation. There some guidelines International Conference...