A5047499201- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- HIV Research and Treatment
- Travel-related health issues
- Viral Infections and Vectors
- Hemoglobinopathies and Related Disorders
- Computational Drug Discovery Methods
- Hepatitis Viruses Studies and Epidemiology
- Diverse Scientific Research Studies
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Diagnosis and treatment of tuberculosis
- Hepatitis B Virus Studies
- Amoebic Infections and Treatments
- Demographic Trends and Gender Preferences
- Iron Metabolism and Disorders
- Vibrio bacteria research studies
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Escherichia coli research studies
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Milk Quality and Mastitis in Dairy Cows
Bangabandhu Sheikh Mujib Medical University
2024
QIMR Berghofer Medical Research Institute
2017-2023
International Centre for Diarrhoeal Disease Research
2007-2022
Comilla Medical College
2020
The University of Queensland
2017
Stamford University Bangladesh
2016
Medical University of Vienna
2007
BRAC
2007
University of Tsukuba
2007
Centre de recherche en Epidémiologie et Santé des Populations
2005
Customer Lifetime Value (CLV) is a critical metric in marketing analytics, enabling businesses to assess long-term profitability and optimize customer retention strategies. Traditional CLV models rely on heuristic approaches such as Regency, Frequency, Monetary (RFM) analysis, but the advent of Artificial Intelligence (AI) Machine Learning (ML) has significantly enhanced predictive capabilities. This study explores integration AI-driven ML algorithms with RFM analysis improve forecasting...
Background Pregnancy is a known risk factor for malaria which associated with increased maternal and infant mortality morbidity in areas of moderate-high transmission intensity where Plasmodium falciparum predominates. The nature impact malaria, however, not well understood pregnant women residing low, unstable P. vivax co-exist. Methods A large longitudinal active surveillance study was conducted the Chittagong Hill Districts Bangladesh. Over 32 months 2010–2013, period prevalence...
Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites protect against malaria. Studies mice have elucidated cells molecules driving humoral to Plasmodium, including CD4+ T cells, B interleukin (IL)-21 ICOS. IL-6, a cytokine readily detected Plasmodium-infected humans, is recognized other systems as driver of immunity. Here, we examined effect infection-induced IL-6 on Plasmodium. Using P. chabaudi...
Background Malaria is endemic in 13 of 64 districts Bangladesh, representing a population at risk about 27 million people. The highest rates malaria Bangladesh occur the Chittagong Hill Districts, and Plasmodium falciparum (predominately chloroquine resistant) most prevalent species. Methods objective this research was to describe epidemiology symptomatic P. an area following introduction national control program. We carried out surveillance for due two demographically defined unions...
Background.Cryptosporidium species are a common cause of diarrhea, which can be severe and protracted in young children immunocompromised individuals. Methods. A cohort 226 Bangladeshi aged 2–5 years was prospectively followed for >3 to study the role host genetics susceptibility infection, as well community impact cryptosporidiosis on this population. Results. Ninety-six (42.5%) received diagnosis Cryptosporidium infection. total 51 (22.6%) had asymptomatic Fifty-eight (25.7%)...
Until recently the Chittagong Hill tracts have been hyperendemic for malaria. A past cross-sectional RDT based survey in 2007 recorded rates of approximately 15%. This study was designed to understand present epidemiology malaria this region, monitor and facilitate uptake intervention activities national programme serve as an area developing new innovative control strategies research field established two rural unions Bandarban District Bangladesh north city, which are known be endemic due...
Severe malaria and associated high parasite burdens occur more frequently in humans lacking robust adaptive immunity to Plasmodium falciparum Nevertheless, the host may partly control blood-stage numbers while is gradually established. Parasite has typically been attributed enhanced removal of parasites by host, although vivo quantification this phenomenon remains challenging. We used a unique approach determine fate single cohort semisynchronous, berghei ANKA- or yoelii 17XNL-parasitized...
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture release multiple infective merozoites, parasitised RBC (pRBC) can reach very high numbers in vivo, process that correlates with disease severity humans experimental animals. Thus, controlling pRBC prevent or ameliorate malaria. In endemic regions, circulating parasite-specific antibodies associate immunity to parasitemia. Although vitro assays reveal protective...
ObjectivesAn analysis of the risk factors and seasonal spatial distribution individuals with subclinical malaria in hypoendemic Bangladesh was performed.MethodsFrom 2009 to 2012, active surveillance without regard symptoms conducted on a random sample (n = 3971) pregnant women 589) during cohort study population 24 000.ResultsThe overall Plasmodium falciparum point prevalence 1.0% 35), but 3.2% 18) for women. The estimated incidence 39.9 per 1000 person-years population. Unlike symptomatic...
In recent studies, the combination of azithromycin and artesunate has proven to be a promising alternative for treatment uncomplicated falciparum malaria.We conducted randomized, controlled clinical trial assessing efficacy azithromycin-artesunate therapy. The study was involving 228 patients aged 8-65 years. Patients were randomized 1 2 cohorts at ratio 2:1, receiving either once daily 3 days (30 mg/kg per day plus 4 artesunate) or an adult dose 80 mg artemether 960 lumefantrine (4 tablets...
In the past many regions of Bangladesh were hyperendemic for malaria. Malaria control in 1960s to 1970s eliminated malaria from plains but Chittagong Hill Tracts remained a difficult reservoir. The have areas with between 1 and 10% annual rates, predominately 90-95% Plasmodium falciparum. Southeast Asia, multiplicity infection hypo-endemic has been approximately 1.5. Few studies on genetic diversity P. falciparum performed Bangladesh. Anderson et al. study Khagrachari, northern 2002 203...
Malaria is endemic in the Chittagong Hill Districts of southeastern Bangladesh. Previous epidemiological analyses identified agricultural practice jhum cultivation as a potential risk factor for malaria infection. We conducted qualitative interviews with cultivators and surveillance workers to describe used demographic two study unions from May 2010 August 2012 better understand relationship between Qualitative revealed that on remote, steep hillsides by ethnic tribal groups. Quantitative...
Hemoglobin E is largely confined to south and southeast Asia. The association between hemoglobin (HbE) malaria less clear than that of S C. As part a study in the Chittagong Hill Districts Bangladesh, an initial random sample 202 individuals showed 39% 49% Marma Khyang ethnic groups, respectively, were positive for either heterozygous or homozygous E. In this group, 6.4% also found be severely deficient 35% mildly glucose-6-phosphate dehydrogenase (G6PD). separate Plasmodium falciparum...
Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry Health recently changed national treatment guidelines artemisinin-based combination therapies. The purpose this study was determine baseline therapeutic efficacy artemether-lumefantrine used as a six-dose regimen for uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in study; cure rate 42-day follow-up...
Background: Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histoly-tica requires specific diagnosis for therapy. Differentiation between ID non-inflammatory (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with leucocytes. Lactoferrin indicates an inflammatory process as a marker We evaluated diagnostic values of lactoferrin latex aggluti- nation (LT) either alone or in combination FOBT, correlating stool...
Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by host nutrient status and circadian rhythm; whether inflammatory responses also influence maturation remains less clear. Here, we observed that systemic inflammation induced in mice an innate immune stimulus, lipopolysaccharide (LPS), or ongoing acute Plasmodium infection, slowed the progression a single cohort from one generation RBC to next. Importantly, plasma LPS-conditioned acutely infected directly...
While milk is well known to be a balanced diet with its high nutritional values, conversely and products may serve as potential substrate for the growth proliferation of range microorganisms which in turn fatally influences mass public health. Current study attempted examine likelihood microbial contamination within some common consumed by locality city Dhaka, Bangladesh. All samples exhibited presence bacterial fungal 102-104 cfu/mL 102-103 cfu/mL, respectively. Among specific pathogens,...
A recent active cross sectional survey by a rapid diagnostic test (RDT) in 2007 showed crude malaria prevalence is 11% among the 1.5 million people most at risk for Bangladesh. An randomized population surveillance was initiated JHMRI and ICDDR,B Kuhalong union near hypoendemic Bandabarn Chittagong hill tracts of The 11,000 with approximately 2,000 households which were enumerated baseline census GIS mapping component. demographic system knowledge attitude practice surveys have been obtained...
Background: Colorectal cancer (CRC) is a common malignancy with significant genetic heterogeneity. Mutations in proto-oncogenes such as KRAS, NRAS, and BRAF play pivotal role CRC development, impacting prognosis treatment. This study aims to correlate mutations these genes tumor localization both primary metastatic the Bangabandhu Sheikh Mujib medical university (BSMMU) cohort. Methods: prospective cross-sectional was conducted between July 2023 June 2024 at BSMMU. A total of 30 patients,...
Background:The prevalence of hypothyroidism in the reproductive age group is found up to 4%.In many studies it had been claimed that, thyroid status directly involved women system.Although differs several places, communities, geographic areas and age-groups but deserves more attention from health physicians even world communities.Hypothyroidism can be easily detected by assessing serum stimulating hormone levels.Aim study: The aim this study was dig out infertile assess their responses...