A5037593276- Gene Regulatory Network Analysis
- Gut microbiota and health
- Microfluidic and Bio-sensing Technologies
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Analog and Mixed-Signal Circuit Design
- Microbial Metabolic Engineering and Bioproduction
- Pharmaceutical and Antibiotic Environmental Impacts
- Protein Structure and Dynamics
- Molecular Communication and Nanonetworks
- Probiotics and Fermented Foods
- Cell Image Analysis Techniques
Genome Institute of Singapore
2022-2024
Agency for Science, Technology and Research
2024
Massachusetts Institute of Technology
2019-2020
Dartmouth College
2020
Abstract Long-term colonization of the gut microbiome by carbapenemase-producing Enterobacteriaceae (CPE) is a growing area public health concern as it can lead to community transmission and rapid increase in cases life-threatening CPE infections. Here, leveraging observation that many subjects are decolonized without interventions within year, we used longitudinal shotgun metagenomics (up 12 timepoints) for detailed characterization ecological evolutionary dynamics cohort CPE-colonized...
Tissue homeostasis (feedback control) is an important mechanism that regulates the population of different cell types within a tissue. In type-1 diabetes, auto-immune attack and consequent death pancreatic β cells result in failure loss organ function. Synthetically engineered adult stem with homeostatic control based on digital logic have been proposed as solution for regenerating cells. Such previously circuits thus far unable to reliably both stem-cell proliferation differentiation. Using...
We have previously described a technique for rigorously converting arbitrary biological circuits to electronic circuit schematics that represent them exactly and quantitatively [1], [5], [12]. The enables us simulate model an experimental microbial synthetic amplifier with in Cadence, widely used integrated-circuit design tool very-large-scale silicon chips [2]. Our is excellent accord measured data both the closed-loop open-loop operation of operational amplifier. In addition, because...
The explosive growth in semiconductor integrated circuits was made possible large part by design automation software. and/or analysis of synthetic and natural living cells could be more scalable using the same approach. We present a compiler which converts standard representations chemical reaction networks into hardware configurations that can used to simulate network on specialized cytomorphic hardware. also creates circuit–level models target configuration, enhances versatility enables...
Abstract Long-term colonization of the gut microbiome by carbapenemase-producing Enterobacteriaceae (CPE) is a growing area public health concern as it can lead to community transmission and rapid increase in cases life-threatening CPE infections. Leveraging observation that many subjects are decolonized without interventions within year, we used longitudinal shotgun metagenomics (up 12 timepoints) for detailed characterization ecological evolutionary dynamics cohort CPE-colonized family...
Abstract The distribution of microorganisms in built environments with high human traffic, such as food centres, can potentially have a significant impact on public health, particularly the context increasing worldwide incidence and fomite-related outbreaks. In several major Asian cities, centres are main venue for consumption yet we lack baseline understanding their environmental microbiomes. We conducted city-wide metagenomic surveillance food-centre microbiomes Singapore (16 n=240...