A5102814419- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Parathyroid Disorders and Treatments
- Multiple and Secondary Primary Cancers
- Pharmacology and Obesity Treatment
- PI3K/AKT/mTOR signaling in cancer
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
Ospedale Sant'Anna
2021-2025
Azienda Socio Sanitaria Territoriale Lariana
2021-2025
Universidade Federal de São Paulo
2025
Azienda Ospedaliero-Universitaria Careggi
2023
Agostino Gemelli University Polyclinic
2023
Università Cattolica del Sacro Cuore
2023
University of Bern
2023
University of Padua
2023
Azienda Unità Sanitaria Locale 11 di Empoli
2023
Marche Polytechnic University
2010-2020
Percutaneous radiofrequency thermal ablation (RTA) was reported as an effective tool for the management of thyroid nodules (TNs). The aim this study to investigate effects RTA and establish whether they were treatment-related by comparison with a matched, untreated control group.The population included 40 patients compressive TNs: 22 had nontoxic TNs, 18 toxic TNs treated methimazole. In all patients, fine-needle aspiration cytology performed exclude malignancy.Twenty (group A), 20 others...
Lactate dehydrogenase (LDH) represents a predictive factor in colorectal cancer patients treated with the angiogenesis inhibitor PTK/ZK. We explored role of pre-treatment LDH serum levels receiving first-line bevacizumab.Metastatic bevacizumab was eligible. A control group including all consecutive chemotherapy alone also considered. Pre-treatment were collected for cases.Median progression-free survival (PFS) high and low 4.2 8 months, respectively (P=0.0003). Median overall (OS) 19.6 34.9...
In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is important predictive factor in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Sorafenib represents the therapeutic stronghold advanced HCC patients. a tyrosine kinase inhibitor (TKI) mainly directed against angiogenetic pathway, correlation sorafenib administration...
Radioactive iodine is a crucial tool for treatment of differentiated thyroid cancer (DTC). In 5% cases, DTCs lose I-131 avidity and assume an aggressive behaviour. Treatment options iodine-refractory DTC are limited. We report the experience off-label use tyrosine kinase inhibitor sorafenib advanced DTC.Patients with progressive refractory to radioactive were treated used independently from their performance status. Primary study end-points radiological response, progression-free survival...
Acne is a common and complex skin disease, with very pathogenesis. Although in women the relationship between acne insulin resistance well known, particular PCOS, males this has been poorly investigated. In total, 20 subjects an altered metabolic profile were considered for study randomized as follows: 10 patients treated metformin plus hypocaloric diet 6 months (group A), while did not receive any treatment only followed up B). All of group A, after therapy, had statistically significant...
Bariatric surgery, as Roux-en-Y gastric bypass (RYGB), laparoscopic banding (LGB), and sleeve gastrectomy (LSG), is considered the gold standard treatment to achieve long-term weight loss in severe obesity. In patients who fail maintain achieved weight, pharmacological may be required. Here, we reported our real-life experience on efficacy of liraglutide therapy 62 regained after bariatric surgery.We retrospectively evaluated (60 F-2 M; mean age: 43.6 ± 9.9 years) received for surgery (17...
Currently, sunitinib represents one of the therapeutic strongholds for renal cell carcinoma, but criteria treatment selection are lacking. We assessed role vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) polymorphisms in prediction clinical outcome metastatic carcinoma (mRCC) patients.A total 84 tumour samples from mRCC patients receiving first-line were tested VEGFR single-nucleotide (SNPs). The SNP results correlated with progression-free survival (PFS) overall...
Context: Usefulness of circulating Chromogranin A (CgA) for the diagnosis neuroendocrine tumors (NEN) is controversial. The aim present study was to assess actual role this marker as diagnostic tool. Methods: Serum blood samples were obtained from 42 subjects affected with NEN, 120 non-endocrine neoplasias (non-NEN) and 100 non-neoplastic benign nodular goitre (NNG). Determination CgA performed by means immunoradiometric assay. Results: levels among NEN-patients not significantly different...
Recently, a new classification for gastric cancer (GC) has been proposed, based on Lauren's histology and anatomic tumour location, identifying three subtypes of disease: type 1 (proximal non diffuse GC), 2 (diffuse GC) 3 (distal GC). Aim our analysis was to compare clinical outcome according different GC (1,2,3) in metastatic patients receiving first-line chemotherapy.Advanced pts treated with combination chemotherapy were included analysis. Pts divided subgroups (type 1, 3) as previously...
Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust methods are needed wide clinical adoption. The aim this study was to assess the accuracy inter-observer reproducibility simplified protocols based on quantitative single-photon emission computed tomography (QSPECT) with a limited number scanning time points. We also updated our injected activity (IA) prescription...
// Michela Del Prete 1 , Riccardo Giampieri Fotios Loupakis 3 Tiziana Prochilo 2 Lisa Salvatore Luca Faloppi Maristella Bianconi Alessandro Bittoni Giuseppe Aprile 4 Alberto Zaniboni Alfredo Falcone Mario Scartozzi 5 Stefano Cascinu Medical Oncology, AO Ospedali Riuniti-Università Politecnica delle Marche, 60126 Ancona, Italy Fondazione Poliambulanza, 25124 Brescia, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, "S. Maria della Misericordia", 33100 Udine, di Cagliari, 09042 Monserrato...
In many tumor types serum lactate dehydrogenase (LDH) levels is an indirect marker of hypoxia, neo-angiogenesis and worse prognosis. However data about hepatocellular carcinoma (HCC) are lacking in the clinical setting patients undergoing transarterial-chemoembolization (TACE) whom hypoxia may represent a molecular key to treatment failure. Aim our analysis was evaluate role LDH pre-treatment determining outcome for with HCC receiving TACE. One hundred fourteen were available analysis. For...
Somatostatin analogues (SSA) represent one of the main therapeutic option in patients affected with functioning well-differentiated neuroendocrine tumours (NETs). There are no studies specifically focusing on NETs associated Multiple Endocrine Neoplasia type 1 (MEN1).To evaluate efficacy long-acting SSA octreotide MEN1 early-stage duodeno-pancreatic NETs.Forty were retrospectively evaluated. Twenty evidence or more MEN1-related < 20 mm size (age range 26-61 years) treated (LAR) as first-line...
Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always adequate. Preclinical findings suggest stem cells influence the biological behaviour independently from stage: objective study was to assess whether a panel stemness markers were correlated with clinical outcome in II and III colon patients. A 66 analysed thus patients divided into two groups (A B) most clustering manner consistent different time relapse...
To report data on the real-world effectiveness and safety of injectable (IS) oral (OS) therapies in obese or overweight diabetes (T2DM) patients glycometabolic control, weight loss (WL) maintenance after use semaglutide. 175 subjects with obesity T2DM were retrospectively assessed. Of these, 129 (75F, 54 M; mean age 61.2 ± 9.8 years) treated IS 46 (24F, 22 65.7 12.8 OS for WL. At baseline, (mW) was 101.8 24.6 kg 95.2 15.0 kg; body mass index (mBMI) 36.7 8.7 kg/m2 34.3 5.3 kg/m2. After 6...
To report the Italian experience on cinacalcet use following its approval by European Medical Agency (EMA) to control hypercalcaemia in patients with primary hyperparathyroidism (PHPT).Retrospective data collection from 100 sporadic (sPHPT) and 35 familial PHPT (fPHPT) followed eight centres between October 2008 March 2011.Albumin-adjusted serum calcium, PTH, 25OHD, daily dose adverse events were recorded during follow-up (1-46 months).Baseline calcium was 2·90 ± 0·27 nmol/l sPHPT 2·75 0·17...