A5012294352- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Gut microbiota and health
Fondazione IRCCS Istituto Nazionale dei Tumori
2022-2025
Mario Negri Institute for Pharmacological Research
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Abstract Background Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children aged 0–14 years. Despite significant efforts, targeted therapies based on identified pathways have not improved survival rates. Research has shown that gut microbiota (GM) can influence brain tumor cell proliferation, suggesting microbiota-gut-brain axis plays a role CNS cancer. Our study aims to assess whether GM composition pediatric exhibits specific characteristics. Methods...
BackgroundStage I epithelial ovarian cancer (EOC) encompasses five histologically different subtypes of tumors confined to the ovaries with a generally favorable prognosis. Despite intrinsic heterogeneity, all stage EOCs are treated complete resection and adjuvant therapy in most cases. Owing lack robust prognostic markers, this often leads overtreatment. Therefore, better molecular characterization could improve assessment risk relapse refinement optimal treatment options.Materials...
Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management best possible access to care remain challenge survival rates lag behind that children diagnosed histologically similar tumors. A better understanding tumor biology differentiates (PEDS-) from AYA-RMS could provide critical information drive new initiatives improve their final outcome. We investigated the functional role miRNAs implicated in development, as they have...