A5099184271- Glioma Diagnosis and Treatment
- Gut microbiota and health
- Diet and metabolism studies
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori
2024-2025
Abstract Background Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children aged 0–14 years. Despite significant efforts, targeted therapies based on identified pathways have not improved survival rates. Research has shown that gut microbiota (GM) can influence brain tumor cell proliferation, suggesting microbiota-gut-brain axis plays a role CNS cancer. Our study aims to assess whether GM composition pediatric exhibits specific characteristics. Methods...
Abstract BACKGROUND This trial evaluated feasibility,response,PFS/OS of a randomization comparing two different RT schedules for DIPG while administering the same systemic treatment. We moreover benefit craniospinal irradiation(CSI) in case disseminated(D) relapse. METHODS Patients: 2-21 years-old with at least radiologically verified (MRI blindly reviewed diagnosis,every 12 weeks thereafter) and symptoms duration below 6 months. Biopsy required if atypical imaging, also allowed after...
Abstract Background We applied the strategy for M+ medulloblastoma across all high-risk subgroups, including LC/A histology, TP53 mutations, and MYC/MYCN amplification. Methods Patients over 3 years old received, after surgery, staging histo-biological analysis, sequential high-dose-methotrexate(HD-MTX), high-dose-etoposide(HD-VP16), high-dose-cyclophosphamide(HD-Cyclo), high-dose-carboplatin(HD-Carbo). Hyperfractionated-accelerated-radiotherapy–craniospinal(HART-CSI), administered twice...
Abstract BACKGROUND First-line therapies for medulloblastoma(MBL) are obtaining higher survival-rates while decreasing late-effects, but treatment at relapse is not yet standardized. We report the experience with MBL re-irradiation(re-RT), its timing and outcome in different clinical settings tumor groups. METHODS Patient’s staging/treatment diagnosis, histotypes/molecular subgroups, site/s, re-treatments reported. RESULTS Between 2002 2019, relapsing patients were 25, median age diagnosis...
Abstract BACKGROUND Central nervous system (CNS) tumors represent the main cause of cancer-related deaths in children diagnosed at 0–14 years. It has been demonstrated that bidirectional interaction between gut microbiota and brain, called microbiota-gut-brain axis, a key role pathophysiological processes, mediating proliferation brain tumor cells. The aim this study was to determine whether composition pediatric patients affected by CNS peculiarities. METHODS We included 42 from clinical...