A5042720251- Mechanical Circulatory Support Devices
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Atrial Fibrillation Management and Outcomes
- Advanced Fluorescence Microscopy Techniques
- Analytical Chemistry and Sensors
- Antimicrobial Peptides and Activities
- Blood properties and coagulation
- Surface Modification and Superhydrophobicity
- Biochemical and Structural Characterization
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Cardiac pacing and defibrillation studies
- Hemostasis and retained surgical items
- Innovative Microfluidic and Catalytic Techniques Innovation
- Venous Thromboembolism Diagnosis and Management
- Silk-based biomaterials and applications
- Nitric Oxide and Endothelin Effects
- Cardiac and Coronary Surgery Techniques
The University of Sydney
2018-2024
The Heart Research Institute
2018-2024
Newtown Hospital
2020
Abstract Thrombosis on blood‐contacting medical devices can cause patient fatalities through device failure and unstable thrombi causing embolism. The effect of material wettability fibrin network formation, structure, stability is poorly understood. Under static conditions, fiber volume density increase in clots formed hydrophilic compared to hydrophobic polystyrene surfaces. This correlates with reduced plasma clotting time increased factor XIIa (FXIIa) activity. These structural...
Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure remains complicated by blood clot formation (thrombosis), triggered biomaterial surfaces and flow conditions. Thrombosis may result in ECMO circuit changes, cause red cell hemolysis, thromboembolic events. Medical device thrombosis is potentiated the interplay between properties, hemodynamic conditions patient pathology, however, contribution importance these factors are poorly understood because many vitro...
Abstract Atherosclerotic plaques are commonly observed at low shear regions, in particular, the left main coronary artery (LMCA) bifurcation. Low regions bifurcations promote endothelial dysfunction, a key factor initiating atherogenesis, however, mechanisms underlying this process poorly understood. Dynamic vitro models critical to investigate but current static and vessels‐on‐chip systems typically lack physiologically complex geometries local changes. Here, bifurcating artery‐on‐a‐chip is...
Purpose: Cardiovascular medical devices such as extracorporeal membrane oxygenation (ECMO) machines are critical for the treatment and management of cardiorespiratory illnesses. However, blood contact with device biomaterials causes dangerous clot formation (thrombosis). In ECMO, clots can grow large enough to occlude circuitry fail device, or may dislodge potentiate stroke embolism in patients. While thrombosis is clinically managed systemic anticoagulation, its associated complications...
Biomaterial Fibrin Clot Structures Stylized fibrin clots are presented in article number 2100988 by Anna Waterhouse and co-workers. Less dense on hydrophobic (right) compared to hydrophilic (left) polystyrene more easily lysed, demonstrating potential for targeted fibrinolytic treatment improved hemocompatible device design.