A5083870898- Polyamine Metabolism and Applications
- Nerve injury and regeneration
- Amino Acid Enzymes and Metabolism
- Biopolymer Synthesis and Applications
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Cell death mechanisms and regulation
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Genetic Neurodegenerative Diseases
- Bacteriophages and microbial interactions
- Cannabis and Cannabinoid Research
- Endoplasmic Reticulum Stress and Disease
- Sulfur Compounds in Biology
- Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Cholinesterase and Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Pluripotent Stem Cells Research
Scuola Normale Superiore
2017
European Brain Research Institute
2011-2017
Scuola Internazionale Superiore di Studi Avanzati
2000-2005
University of Turin
1988-1990
We have identified a class of tau fragments inducing apoptosis in different cellular contexts, including human teratocarcinoma‐derived cell line (NT2 cells) representing committed neuronal precursors. found transition point inside the molecule beyond which lose their ability to induce apoptosis. This is located around one putative caspase‐3 cleavage sites. only site that can be effectively used by vitro, releasing C‐terminal 19 amino acids tau. These results establish as substrate for an...
Pathological changes in the microtubule associated protein tau are a major hallmark of many human dementias collectively defined as tauopathies. In familiar frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), several mutations gene have been identified showing that primary malfunction can lead neurodegeneration. addition mutation at genetic level, number post-translational modifications occur tauopathies, including abnormal phosphorylation aberrant proteolysis...
The biological activities of NGF and its precursor proNGF are quite distinct, due to different receptor binding profiles, but little is known about how regulates gene expression. Whether a purely pro-apoptotic molecule and/or simply "less potent NGF" still matter debate. We performed experiments address this question, by verifying whether specific transcriptional signature, distinct from that NGF, could be identified. To aim, we studied expression regulation in PC12 cells incubated for 1 4...
Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. proNGF induce distinct transcriptional signatures target cells, highlighting their bioactivities. In coexist. It was proposed that relative proNGF/NGF ratio is important for outcomes, especially pathological conditions, since principal form...
ProNGF, the precursor of mature Nerve Growth Factor (NGF), is most abundant NGF form in brain and increases markedly cortex Alzheimer's Disease (AD), relative to NGF. A large body evidence shows that actions ProNGF are often conflicting, depending on receptors expressed target cells. TgproNGF#3 mice, expressing furin-cleavage resistant proNGF CNS neurons, directly reveal consequences increased levels homeostasis. Their phenotype clearly indicates can be a driver neurodegeneration, including...
Neurotrophic factors (NTFs) are involved in the regulation of neuronal survival and function and, thus, may be used to treat neurological diseases associated with death. A major hurdle for their clinical application is delivery mode. We describe here a new strategy based on use progenitor cells called mesoangioblasts (MABs). MABs can isolated from postnatal mesoderm tissues because high adhesin-dependent migratory capacity, reach perivascular targets especially damaged areas. generated...