A5100599448- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- Plant Stress Responses and Tolerance
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Plant Gene Expression Analysis
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Kruppel-like factors research
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- Endoplasmic Reticulum Stress and Disease
- Postharvest Quality and Shelf Life Management
- Plant Reproductive Biology
- Lung Cancer Treatments and Mutations
- Biological Stains and Phytochemicals
Shanghai Zhangjiang Laboratory
2024
Huazhong Agricultural University
2022-2024
China Agricultural University
2020-2024
Hebei North University
2024
Tobacco Research Institute
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
Wuhan Botanical Garden
2024
Chinese Academy of Sciences
2024
Peking University Cancer Hospital
2012-2023
Peking University
2012-2023
Abstract WRKY transcription factors play a central role in controlling plant organ senescence; however, it is unclear whether and how they regulate petal senescence the widely grown ornamental tulip (Tulipa gesneriana). In this study, we report that TgWRKY75 promotes by enhancing synthesis of both abscisic acid (ABA) salicylic (SA) transgenic Arabidopsis. The expression level was up-regulated senescent petals, exogenous ABA or SA treatment induced its expression. endogenous contents...
Abstract Petal senescence is a crucial determinant for ornamental quality and economic value of floral crops. Salicylic acid (SA) reactive oxygen species (ROS) are two prominent factors involved in plant regulation. In this study, tulip TgNAP (NAC-like, activated by APETALA3/PISTILLATA) was characterized as positively regulating petal through dually SA biosynthesis ROS detoxification pathways. upregulated senescing petals while exogenous H2O2 treatments substantially promoted tulip....
Abstract Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation integrin β1 and enhance activation ERK1/2 HEK293 cells. Herein aim to explore association with signaling its functional implications motility, invasion, metastasis colon cancer cell LoVo. Methods Transwell chamber assay nude mouse model were used...
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment Dandan Wang,1,* Xiaowei Xu,2,* Kai Zhang,3 Bin Sun,4 Lu Wang,1 Lin Meng,1 Qilin Liu,4 Changyu Zheng,5 Bai Yang,3 Hongchen Sun1,3,6 1Department Pathology, School Hospital Stomatology, Jilin University, Changchun, People’s Republic China; 2Department Periodontology, 3State Key Laboratory Supramolecular Structure Materials, College Chemistry,...
Abstract Chinese wild rice ( Zizania latifolia ; family: Gramineae) is a valuable medicinal homologous grain in East and Southeast Asia. Here, using Nanopore sequencing Hi-C scaffolding, we generated 547.38 Mb chromosome-level genome assembly comprising 332 contigs 164 scaffolds (contig N50 = 4.48 Mb; scaffold 32.79 Mb). The harbors 38,852 genes, with 52.89% of the repetitive sequences. Phylogenetic analyses revealed close relation Z. to Leersia perrieri Oryza species, divergence time...
Plants subjected to cold stress have been observed accumulate proline, but the underlying regulatory mechanism remains be elucidated. In this study, we identified a pyrroline-5-carboxylate synthetase (P5CS)-encoding gene (CtrP5CS1) from trifoliate orange (Citrus trifoliata L.), cold-hardy citrus species, as critical for cold-induced proline accumulation. CtrTGA2 bound directly TGACG motif of CtrP5CS1 promoter and activated its expression. Moreover, functioned positively in tolerance via...
Abstract Although the VEGF‐Flk‐1‐pathway has been known as major driving force of angiogenesis, new evidence shown that VEGFR‐1/Flt‐1 plays important roles during neovascularization under pathological conditions including tumor, atherosclerosis and arthritis. In search Flt‐1 receptor antagonizing peptides, we screened a phage display 12‐mer‐peptide library with recombinant protein. Seven candidate peptides were identified specifically bound to VEGF Flt‐1, which peptide F56 (WHSDMEWWYLLG)...
The oncogenic phosphatase PRL-3 is highly expressed in metastatic colorectal cancer but not nonmetastatic or noncolorectal cancers. Although the proinvasive capacity of has been validated multiple types cancer, its impact on progression and underlying mechanisms remain poorly understood. Here, we report that overexpressed stimulates G2-M arrest, chromosomal instability (CIN), self-renewal, growth cells xenograft models, while cell proliferation decreased. PRL-3-induced arrest was associated...
Pescadillo is a nucleolar protein that has been suggested to be involved in embryonic development and ribosome biogenesis. Deregulated expression of human pescadillo (PES1) was described some tumors, but its precise roles tumorigenesis remains unclear. In this study, we generated three monoclonal antibodies recognizing PES1 with high specificity sensitivity, which colon cancer analyzed immunohistochemically. Out 265 tissues, 89 (33.6%) showed positive expression, significantly higher than...
Plasma membrane damage in vitrified oocytes is closely linked to mitochondrial dysfunction. However, the mechanism underlying mitochondria-regulated stability not elucidated. A growing body of evidence indicates that activity plays a pivotal role cell adaptation. Since mitochondria work at higher temperature than constant external cell, we hypothesize suppressing would protect from extreme stimuli during vitrification. Here show metformin suppresses by reducing temperature. In addition,...
PRL-3 is a member of phosphatases regenerating liver family, characterized by phosphatase active domain and C-terminal prenylation motif. Overexpression has been implicated in multiple cancers. Here we examined the clinical significance gastric cancer together with its metastatic biological functions utilizing different structural mutants. expression was analyzed immunohistochemically 196 patients 21 cases metastasis. A series wild type or mutant plasmids were expressed BGC823 cells to...
A Gram-stain-positive, endospore-forming, moderately halophilic bacterial strain, NEAU-ST10-40 T , was isolated from a saline and alkaline soil in Anda City, China. It strictly aerobic, rod-shaped motile by peritrichous flagella. formed light yellow colonies grew at NaCl concentrations of 3–15 % (w/v) (optimum, 8 %, w/v), pH 7.0–9.0 8.0) 4–60 °C 30 °C). contained meso -diaminopimelic acid the cell-wall peptidoglycan. Phylogenetic analysis based on 16S rRNA gene sequences indicated that it...
Background: Improvement in drug accumulation the lungs through inhalation administration and high expression of MMP2 MMP9 lung tumors have both been widely reported. Methods: MMP2/9-triggered-release micelles were constructed vitro vivo studies against tumor carried out. Pluronic P123 (P123) was modified with GPLGIAGQ-NH2 (GQ8) peptide to obtain P123-GQ8 (PG). using PG succinylated gelatin (SG) loading paclitaxel (Ptx). To study biodistribution micelles, DiR encapsulated dosed rats via...
Sodium cation compartmentalization into vacuoles is one of the effective strategies for adaptation halophytes to saline environments. Tonoplast Na+/H+ antiporter (NHX) involved in Na+ sequestration under salt stress. However, function NHX halophyte Iris lactea still unclear. In this study, a significant positive correlation was observed between accumulations and IlNHX expression tissues 0 - 200 mM NaCl, indicating might be responsible accumulation I. More important, specifically localized...