A5036900273- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Actinomycetales infections and treatment
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- CAR-T cell therapy research
- Sexual Assault and Victimization Studies
- Pharmacovigilance and Adverse Drug Reactions
- Tuberculosis Research and Epidemiology
- Infectious Aortic and Vascular Conditions
- Antibiotic Use and Resistance
- Intimate Partner and Family Violence
- Infectious Disease Case Reports and Treatments
- Chemotherapy-related skin toxicity
- Maternal and fetal healthcare
- Patient Satisfaction in Healthcare
- Reproductive tract infections research
- Reproductive Health and Contraception
Mayo Clinic in Florida
2015-2024
Mayo Clinic
2011-2022
WinnMed
2022
Mayo Clinic in Arizona
2011-2021
Wheaton Franciscan Healthcare
2017-2018
Mayo Clinic Health System
2017-2018
The administration of spike monoclonal antibody treatment to patients with mild moderate COVID-19 is very challenging. This article summarizes essential components and processes in establishing an effective infusion program. Rapid identification a dedicated physical infrastructure was circumvent the logistical challenges caring for infectious while maintaining compliance regulations ensuring safety our personnel other patients. Our partnerships collaborations among multiple different...
Detection of the Histoplasma capsulatum urinary antigen (UAg) is among most sensitive and rapid means to diagnose histoplasmosis. Previously, we evaluated analyte-specific reagents (ASR) manufactured by IMMY (Norman, OK) for detection galactomannan (GM) in urine using an enzyme immunoassay (EIA), showed low positive agreement (64.5%) with MiraVista (MVista) (Ag) quantitative EIA (MiraVista Diagnostics, Indianapolis, IN). Here reevaluated GM ASR following modification our original assay...
ObjectiveTo report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.MethodsWe conducted a retrospective chart review of patients COVID-19 diagnosed between March 1, 2020, and July 31, at any sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, treatments received. Factors associated hospitalization mortality were assessed in univariate multivariate models.ResultsA total 7891...
ABSTRACT Background In COVID-19, high levels of granulocyte macrophage-colony stimulating factor (GM-CSF) and inflammatory myeloid cells correlate with disease severity, cytokine storm, respiratory failure. With this rationale, we used lenzilumab, an anti-human GM-CSF monoclonal antibody, to treat patients severe critical COVID-19 pneumonia. Methods Hospitalized pneumonia risk factors for poor outcomes were treated lenzilumab 600 mg intravenously three doses through emergency single-use IND...
To assess the effect of a pharmacist-driven, polymerase chain reaction (PCR)-based nasal screening protocol for methicillin-resistant Staphylococcus aureus (MRSA) on vancomycin therapy duration and rates adverse drug events 30-day hospital readmission.From July 8, 2017, through January 31, 2019, we performed retrospective, multicenter, preimplementation-postimplementation study. Patients with order to treat lower respiratory tract infection (LRTI) underwent MRSA PCR screening; tests were...
A 42-year-old woman with uterine fibroids underwent myomectomy. She developed postoperative sepsis and bloodstream infection Clostridium hathewayi secondary to an infected haematoma. The patient was readmitted after failure of oral antibiotic therapy intrauterine drainage followed by prolonged parenteral therapy. for 1 year did not have any relapse infection.
Abstract Purpose Emerging literature has detailed the safe use of cefazolin in patients with immunoglobulin E–mediated penicillin allergy labeling (PAL) such as hives and anaphylaxis. The purpose this article is to detail efforts led by an antimicrobial stewardship pharmacist working interdisciplinary team optimize preoperative antimicrobials PAL. Methods A pharmacist-led, collaborative practice agreement (CPA) was activated January 2020 permit pharmacists independently antibiotics preferred...
A 65-year-old woman with osteoarthritis, who underwent knee replacement 5 years prior, developed sudden onset pain and swelling. She had voluntarily starting a vigorous dental flossing regimen prior to the of symptoms. The patient right arthrotomy, irrigation debridement total arthroplasty exchange polyethylene retention prosthesis. Intraoperative cultures grew Streptococcus gordonii . was treated 6 weeks ceftriaxone later placed on oral antibiotic suppression.
Peripheral stents are increasingly used for treatment of peripheral arterial disease, yet all implanted devices potentially at risk infection. We describe a 51-year-old man who underwent stenting in the femoropopliteal artery and presented 3 days later with leg pain, fever, evidence stigmata embolization. Blood cultures grew methicillin-resistant Staphylococcus aureus remained persistently positive despite antibiotic therapy. At surgical exploration, popliteal had essentially been...
Lactobacilli are common commensal bacteria found in the gastrointestinal and genitourinary tract. Although they usually thought to be nonpathogenic, there have been several cases that demonstrate severe infections caused by these microorganisms. This is a case of 49-year-old male with previously undiagnosed type two diabetes mellitus who presented 3-month history cough was right sided Lactobacillus gasseri empyema for which he underwent video-assisted thoracoscopic surgery (VATS) chest tube...
Background: Antibiotic therapy with a macrolide and β-lactam or fluoroquinolone for the empirical treatment of community-acquired pneumonia (CAP) in an inpatient non–intensive care setting is recommended per guidelines. Studies show that these treatments have similar outcomes, including death, adverse effects, bacterial eradication. However, comparison 30-day readmission rates between limited. Study Question: To determine whether readmissions patients treated CAP regional hospital differed...
Recent literature demonstrated a 24-hour reduction in vancomycin duration of therapy (DOT) for skin and soft tissue infections (SSTIs) with negative methicillin-resistant staphylococcus aureus (MRSA) nasal screening versus positive screening. Objective this study was to investigate DOT patients SSTIs who received MRSA polymerase chain reaction (PCR) those did not receive PCR
To assess the effect of clinical pharmacists in daily audits, under direction an antimicrobial stewardship program, antibiotic treatment durations for common inpatient disease states community-acquired pneumonia (CAP) and urinary tract infection (UTI).
A 66-year-old, Caucasian male presented with pain and swelling involving the left knee of one-week duration. Arthrocentesis was negative for evidence septic arthritis. Magnetic resonance imaging (MRI) study showed degenerative arthritis, partial tear medial meniscus, a complex fluid collection along posteromedial aspect suggestive popliteal cyst. He underwent arthroscopy meniscectomy. Intraoperative joint noted to be cloudy but cultures were negative. Arthroscopic procedure provided him...
Introduction Anti-interleukin-6 agents such as Tocilizumab (Actemra) are increasingly being used in patients with rheumatoid arthritis who did not have good clinical response to TNF (Tumor necrosis factor) inhibitors. Interleukin-6 is a key cytokine the pathogenesis of several autoimmune disorders. Pneumocystis jirovecii an opportunistic pathogen that causes pneumonia immunocompromised HIV positive individuals low CD4 count. There limited data about risk pneumocystis associated newer...
Introduction Lactobacilli are common commensal bacteria found in the gastrointestinal and genitourinary tract. Although they usually thought to be non-pathogenic, there have been few reported cases that showcase severe infections caused by these microorganisms. This is first case of a bilateral empyema with bacterial cultures growing only Lactobacillus gasseri setting undiagnosed type 2 DM. Case description Previously healthy 49-year-old male, presented emergency room 3 month history...
Watts, Charles; Kerezoudis, Panagiotis; Dababneh, Ala; Pupillo, Gregory; Deyo, Christopher; Frye, Judson; Gehrke, Kristof; Kelley, Parker; Kemp, Anna; Palraj, Bharath Raj Varatharaj Author Information
Background: Serum procalcitonin is a marker that useful to differentiate patients with bacterial infections from viral infections. In the clinical setting, low serum level has good negative predictive value and may be used identify who not benefit antibacterial therapy. However elevated due several other conditions than significant infectious process Methods & Materials: 76-year-old retired physician presented after fall at home complained of few day history malaise, muscle aches, weakness...
Abstract Background Sexual assault survivors are at increased risk for sexually transmitted infections. Due to patient vulnerability, institutions have implemented Assault Nurse Examiner (SANE) protocols care these patients. These guide evidence collection, testing, treatment, and medical follow-up ensure optimization of infections (STIs) monitoring follow-up. Previous gap analyses identified decreased prescribing prophylactic STI medications scheduling appointments compared guideline...