A5081951764- Infective Endocarditis Diagnosis and Management
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Orthopedic Infections and Treatments
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Infectious Diseases and Mycology
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Diseases and Tuberculosis
- Vector-borne infectious diseases
- Tuberculosis Research and Epidemiology
- Nail Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Actinomycetales infections and treatment
- Viral Infections and Vectors
- Infectious Aortic and Vascular Conditions
- Hematological disorders and diagnostics
- Cytomegalovirus and herpesvirus research
- Rabies epidemiology and control
- Cardiac pacing and defibrillation studies
- Prostate Cancer Diagnosis and Treatment
Mayo Clinic
2017-2025
Mayo Clinic in Florida
2017-2025
WinnMed
2017-2025
Mayo Clinic in Arizona
2017-2024
Emek Medical Center
2022-2024
University of Freiburg
2024
Boston University
2024
Soroka Medical Center
2023
Tokyo Medical and Dental University
2023
Office of Infectious Diseases
2020-2021
The use of ceftriaxone, a highly protein-bound drug, in the setting hypoalbuminemia may result suboptimal drug exposure. Patients with obesity also exhibit higher absolute clearance. We aimed to evaluate impact on clinical success among hospitalized adults who were treated ceftriaxone. This retrospective review included adult inpatients weight >100 kg or body mass index >40 kg/m
Abstract Background The underlying cause of fever unknown origin (FUO) remains unidentified in up to 51% cases despite systematic evaluation. Microbial cell-free DNA next-generation sequencing (mcfDNA-NGS) offers an agnostic, noninvasive approach pathogen identification, but the utility and clinical impact this assay FUO remain unknown. Methods This retrospective cohort study evaluated adult patients referred for evaluation at a tertiary medical center between November 2019 2023. Patients...
Infective endocarditis (IE) is a life-threatening infection often challenging to diagnose, particularly in culture-negative cases. Plasma microbial cell-free DNA (mcfDNA) sequencing has shown potential for detecting pathogens IE. However, its clinical utility, diagnostic impact, and limitations remain debated. This study evaluates use diagnosing managing IE tertiary care setting. single-center retrospective cohort included adult patients (≥18 years) who underwent mcfDNA via the Karius test...
Women undergoing radical cystectomy (RC) and urinary diversion for bladder cancer experience substantial limitations in health-related quality of life (HRQOL). However, the level discomfort caused by different has been never evaluated long term survivors. The aim this multicenter study is to evaluate differences HRQOL among recurrence-free women cutaneous ureterostomy (CUS), Bricker's ileal conduit (BK-IC) Orthotopic neobladder VIP (ONB-VIP) disease-free females treated with (RC), long-term...
Nocardia species are found worldwide and opportunistic pathogens of both immunocompromised immunocompetent hosts. Recent updates to the taxonomy this genus have indicated that there more than 90 recognized with 54 reported be clinically relevant.
Abstract Ten case reports of disseminated Mycobacterium chimaera infections associated with cardiovascular surgery were published from Europe. We report 3 cases M histories aortic graft and/or valvular within the United States. Two patients demonstrated ocular involvement, a potentially important clinical finding.
Accurate microbiologic diagnosis is important for appropriate management of infectious diseases. Sequencing-based molecular diagnostics are increasingly used precision infections. However, their clinical utility unclear.We conducted a retrospective analysis specimens that underwent 16S ribosomal RNA (rRNA) gene polymerase chain reaction (PCR) followed by Sanger sequencing at our institution from April 2017 through March 2019.A total 566 obtained 460 patients were studied. Patients considered...
ObjectivesWe describe our multicenter experience on diagnosis and management of Aerococcus bacteremia including the susceptibility profile species a suggested algorithm for clinicians.MethodsRetrospective study all patients with positive blood cultures from January 2005 to July 2020 in institution clinical data profile. Data were collected both electronic health record microbiology laboratory database.ResultsThere 219 unique isolates only profiles available, while 81 had information...
Capnocytophaga is a gram-negative, facultative anaerobe. Human infection rare but can lead to devastating outcomes. canimorsus cause sepsis following an animal bite, whereas human-oral-associated infections were reported in immunocompromised patients. Current data on these are not robust. Our goal provide contemporary description of unique characteristic infections.We performed retrospective review all patients with from January 2010 August 2020 at 3 main hospitals Mayo Clinic Rochester,...
Melanoma, a malignant neoplasm originating from melanocytes, stands as one of the most prevalent cancers globally, ranking fifth in terms estimated new cases recent years. Its aggressive nature and propensity for metastasis pose significant challenges oncology. Recent advancements have led to notable shift towards targeted therapies, driven by deeper understanding cutaneous tumor pathogenesis. Immunotherapy tyrosine kinase inhibitors emerged promising strategies, demonstrating potential...
Recent advances in shotgun metagenomic sequencing (sMGS) for detecting microbial cell-free DNA (mcfDNA) peripheral blood have shown promise across various patient populations. This study evaluates the application of sMGS diagnosing osteoarticular infections (OAIs), a condition with significant diagnostic challenges. We conducted retrospective analysis on 73 patients suspected OAIs at Mayo Clinic from 2019 to 2023, incorporating mcfDNA (Karius test [KT]) into their evaluation. categorized...
Stenotrophomonas maltophilia is a gram-negative, opportunistic infection that usually hospital-acquired and associated with high morbidity mortality. The reported increase in S. infections presumed to be due an the population at risk.We retrospectively reviewed 10-year data for bacteremia hospitalized adults our institution determine risk, sources of infection, common complications, antimicrobial susceptibility profiles, clinical outcome trends over past decade.Among 98 patients analyzed,...
Immune checkpoint inhibitors are a class of cancer treatment drugs that stimulate the immune system's ability to fight tumor cells. These monoclonal antibodies targeting im-mune-inhibiting proteins on cells, such as CTLA-4 and PD-1/PD-L1. cause many immune-related adverse events. Cutaneous toxicities most common effects occur with range severity. Bullous Pemphigoid is rare event high impact quality life may after inhibitor treatment. In this article, we investigate current research...
Cutaneous squamous cell carcinoma (cSCC) of the skin is second most common form cancer, with aging and prolonged exposure to ultraviolet rays being main causes disease. Cemiplimab pembrolizumab recently gained regulatory approval for treatment locally advanced metastatic cSCC-conditions that are not treatable by surgical resection and/or radiotherapy. Although results from clinical trials have been promising, these studies included immunosuppressed, elderly patients. In this study, we all...
ObjectiveTo report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.MethodsWe conducted a retrospective chart review of patients COVID-19 diagnosed between March 1, 2020, and July 31, at any sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, treatments received. Factors associated hospitalization mortality were assessed in univariate multivariate models.ResultsA total 7891...
Itraconazole is well known for carrying a black-box warning new or worsening congestive heart failure. Single cases of other cardiac- and fluid-related disturbances have been reported periodically since its issuance. We describe large cohort patients on itraconazole experiencing breadth toxicities, ranging from new-onset hypertension to cardiac arrest. A retrospective, single-center, case series at tertiary medical center was conducted. Patients with toxicity-including hypertension,...